ATE184323T1 - NUCLEIC ACID DETECTION - Google Patents
NUCLEIC ACID DETECTIONInfo
- Publication number
- ATE184323T1 ATE184323T1 AT92914059T AT92914059T ATE184323T1 AT E184323 T1 ATE184323 T1 AT E184323T1 AT 92914059 T AT92914059 T AT 92914059T AT 92914059 T AT92914059 T AT 92914059T AT E184323 T1 ATE184323 T1 AT E184323T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleic acid
- binding
- enzyme
- interest
- probe
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Abstract
Disclosed is a homogeneous assay method for determining the presence of a nucleic acid sequence of interest in a sample, comprising combining in solution: the sample; a first nucleic acid probe substantially complementary or homologous to at least part of the sequence of interest and associated, or capable of being associated, with an enzyme or a substance capable of affecting the activity of an enzyme; a second probe capable of binding to the first probe or capable of binding to at least part of the sequence of interest and comprising a ligand moiety; and a binding partner capable of binding to said ligand moiety, the arrangement being such that when the first and second probes are bound in proximity an effect of the binding partner on enzyme behaviour is altered; and monitoring said enzyme behaviour.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919114525A GB9114525D0 (en) | 1991-07-05 | 1991-07-05 | Homogeneous nucleic acids probe based tests and substances |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE184323T1 true ATE184323T1 (en) | 1999-09-15 |
Family
ID=10697855
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92914059T ATE184323T1 (en) | 1991-07-05 | 1992-07-06 | NUCLEIC ACID DETECTION |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0602049B1 (en) |
| JP (1) | JPH06508753A (en) |
| AT (1) | ATE184323T1 (en) |
| AU (1) | AU2231392A (en) |
| CA (1) | CA2112670A1 (en) |
| DE (1) | DE69229954D1 (en) |
| GB (2) | GB9114525D0 (en) |
| WO (1) | WO1993001313A1 (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9403953D0 (en) * | 1994-07-15 | 1994-11-16 | Pharmacia Biotech Ab | Sequence-based diagnosis |
| JP6430253B2 (en) * | 2011-11-05 | 2018-11-28 | プレジデント アンド フェローズ オブ ハーバード カレッジ | Nucleic acid-based linkers for detecting and measuring interactions |
| US11198900B2 (en) | 2014-12-06 | 2021-12-14 | Children's Medical Center Corporation | Nucleic acid-based linkers for detecting and measuring interactions |
| US11396650B2 (en) | 2015-06-02 | 2022-07-26 | Children's Medical Center Corporation | Nucleic acid complexes for screening barcoded compounds |
| US11713483B2 (en) | 2016-02-09 | 2023-08-01 | Children's Medical Center Corporation | Method for detection of analytes via polymer complexes |
| US10919037B2 (en) | 2016-03-23 | 2021-02-16 | Children's Medical Center Corporation | Systems and apparatus for detecting compounds in human biological samples |
| US11591636B2 (en) | 2017-11-20 | 2023-02-28 | Children's Medical Center Corporation | Force-controlled nanoswitch assays for single-molecule detection in complex biological fluids |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0144914A3 (en) * | 1983-12-12 | 1986-08-13 | Miles Inc. | Hybridization assay employing labeled pairs of hybrid binding reagents |
| EP0144913A3 (en) * | 1983-12-12 | 1986-08-20 | Miles Inc. | Hybridization assay employing labeled probe and anti-hybrid |
| DE3479522D1 (en) * | 1983-12-16 | 1989-09-28 | Medisense Inc | Assay for nucleic acids |
| EP0199801B1 (en) * | 1984-10-29 | 1993-08-25 | MICROGENICS CORPORATION (a Delaware corporation) | Methods for protein binding enzyme complementation assays |
| ATE88761T1 (en) * | 1986-01-10 | 1993-05-15 | Amoco Corp | COMPETITIVE HOMOGENEOUS TEST. |
| EP0638807B1 (en) * | 1987-09-21 | 2002-07-17 | Gen-Probe Incorporated | Protection assay |
| ATE95246T1 (en) * | 1988-02-26 | 1993-10-15 | Profile Diagnostic Sciences | METHOD FOR DETERMINING GENETIC SEQUENCES AND TEST KIT THEREFOR. |
| EP0343955A3 (en) * | 1988-05-27 | 1990-04-18 | Bioventures, Inc. | Process for complex binding of targeted molecular species |
-
1991
- 1991-07-05 GB GB919114525A patent/GB9114525D0/en active Pending
- 1991-09-13 GB GB919119650A patent/GB9119650D0/en active Pending
-
1992
- 1992-07-06 EP EP92914059A patent/EP0602049B1/en not_active Expired - Lifetime
- 1992-07-06 JP JP5502095A patent/JPH06508753A/en not_active Withdrawn
- 1992-07-06 AU AU22313/92A patent/AU2231392A/en not_active Abandoned
- 1992-07-06 CA CA002112670A patent/CA2112670A1/en not_active Abandoned
- 1992-07-06 DE DE69229954T patent/DE69229954D1/en not_active Expired - Lifetime
- 1992-07-06 WO PCT/GB1992/001229 patent/WO1993001313A1/en active IP Right Grant
- 1992-07-06 AT AT92914059T patent/ATE184323T1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| GB9119650D0 (en) | 1991-10-23 |
| GB9114525D0 (en) | 1991-08-21 |
| EP0602049B1 (en) | 1999-09-08 |
| EP0602049A1 (en) | 1994-06-22 |
| AU2231392A (en) | 1993-02-11 |
| JPH06508753A (en) | 1994-10-06 |
| DE69229954D1 (en) | 1999-10-14 |
| WO1993001313A1 (en) | 1993-01-21 |
| CA2112670A1 (en) | 1993-01-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |