ATE183T1 - BENZOPYRAN DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR MAKING THE COMPOUNDS AND COMPOSITIONS. - Google Patents
BENZOPYRAN DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR MAKING THE COMPOUNDS AND COMPOSITIONS.Info
- Publication number
- ATE183T1 ATE183T1 AT79810066T AT79810066T ATE183T1 AT E183 T1 ATE183 T1 AT E183T1 AT 79810066 T AT79810066 T AT 79810066T AT 79810066 T AT79810066 T AT 79810066T AT E183 T1 ATE183 T1 AT E183T1
- Authority
- AT
- Austria
- Prior art keywords
- loweralkyl
- lowercycloalkyl
- hydroxy
- hydroxyloweralkyl
- chem
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 150000001562 benzopyrans Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- -1 haloloweralkyl Chemical group 0.000 abstract 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000002541 furyl group Chemical group 0.000 abstract 2
- 125000002971 oxazolyl group Chemical group 0.000 abstract 2
- 125000003386 piperidinyl group Chemical group 0.000 abstract 2
- SMQUZDBALVYZAC-UHFFFAOYSA-N salicylaldehyde Chemical class OC1=CC=CC=C1C=O SMQUZDBALVYZAC-UHFFFAOYSA-N 0.000 abstract 2
- 125000003831 tetrazolyl group Chemical group 0.000 abstract 2
- 125000001113 thiadiazolyl group Chemical group 0.000 abstract 2
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000005518 carboxamido group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 125000006384 methylpyridyl group Chemical group 0.000 abstract 1
- 125000002757 morpholinyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
- C07D239/62—Barbituric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Novel compounds of the formula <CHEM> wherein each of R3 and R5 represents hydrogen or loweralkyl, n is an integer from one to four and R represents hydrogen, loweralkyl, lowercycloalkyl, lowercycloalkyl-loweralkyl, acyloxyloweralkyl, hydroxyloweralkyl, lower-alkoxyloweralkyl, nitro, halogeno, haloloweralkyl, hydroxy, loweralkoxy, acylaminoloweralkyl, aminoloweralkyl, mono- or diloweralkylaminoloweralkyl, alkanoyloxy, carboxy, loweralkoxycarbonyl, acyl, formyl, cyano or a carboxamido moiety of the structure <CHEM> wherein A is straight or branched chain alkyl with up to 12 carbon atoms, lowercycloalkyl, lowercycloalkylloweralkyl, loweralkoxyloweralkyl, hydroxyloweralkyl, fluoroloweralkyl, loweralkenyl, loweralkylthioloweralkyl, loweralkylsulfoxyloweralkyl, loweralkylsulfonylloweralkyl, thiazol, oxazolyl, thiadiazolyl, methylthiadiazolyl, furyl, pyrazolyl, tetrazolyl, methyltetrazolyl, hydroxypyrimidinyl, phenyl, pyrimidynyl-dione, or the grouping <CHEM> wherein E is a straight or branched chain or cyclic loweralkylene, x is zero or one and Q is hydroxy, loweralkoxy, amino or mono- or diloweralkylamino; or the grouping -E-R8, wherein E is as defined above and is optionally substituted by hydroxy and/or phenyl, R8 is phenyl, thiazolyl, oxazolyl, thiadiazolyl, methylthiadiazolyl, tetrazolyl, methyltetrazolyl, furyl, pyridyl, methylpyridyl or piperidinyl; and B is hydrogen, loweralkyl, lowercycloalkyl, lowercycloalkylloweralkyl, or loweralkenyl; or A and B, when taken together with the nitrogen atom to which they are attached, represent imidazolyl, morpholinyl, pyrrolidinyl, piperidinyl or piperazinyl and heterocyclic rings being optionally substituted by hydroxy, loweralkyl or hydroxyloweralkyl; and pharmaceutically acceptable salts thereof. The preparation of these compounds by five methods is described, in particular one inventive method which comprises reacting a correspondingly R-substituted salicylaldehyde and
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92959878A | 1978-07-31 | 1978-07-31 | |
| EP79810066A EP0008277B1 (en) | 1978-07-31 | 1979-07-30 | Benzopyrano derivatives, pharmaceutical compositions containing them and processes for preparing the compounds and compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE183T1 true ATE183T1 (en) | 1981-09-15 |
Family
ID=25458123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT79810066T ATE183T1 (en) | 1978-07-31 | 1979-07-30 | BENZOPYRAN DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR MAKING THE COMPOUNDS AND COMPOSITIONS. |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0008277B1 (en) |
| JP (1) | JPS5522685A (en) |
| AT (1) | ATE183T1 (en) |
| DE (1) | DE2960741D1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3335472A1 (en) * | 1983-09-30 | 1985-04-11 | Gödecke AG, 1000 Berlin | 5H- (1) BENZOPYRANO- (2,3, -D) PYRIMIDINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN THE FIGHT AGAINST GASTRAL AND DUODENAL MUSCLE LESIONS |
| DE3335473A1 (en) * | 1983-09-30 | 1985-04-11 | Gödecke AG, 1000 Berlin | 4-THIOXO-BENZOPYRANO (2,3-D) PYRIMIDINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF |
-
1979
- 1979-07-30 AT AT79810066T patent/ATE183T1/en active
- 1979-07-30 JP JP9716879A patent/JPS5522685A/en active Pending
- 1979-07-30 DE DE7979810066T patent/DE2960741D1/en not_active Expired
- 1979-07-30 EP EP79810066A patent/EP0008277B1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| EP0008277A1 (en) | 1980-02-20 |
| DE2960741D1 (en) | 1981-11-26 |
| EP0008277B1 (en) | 1981-09-02 |
| JPS5522685A (en) | 1980-02-18 |
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