ATE18197T1 - 1'-aethoxycarbonyloxyaethylester der valponsaeure, seine herstellung und diesen enthaltende formulierungen. - Google Patents

1'-aethoxycarbonyloxyaethylester der valponsaeure, seine herstellung und diesen enthaltende formulierungen.

Info

Publication number
ATE18197T1
ATE18197T1 AT84300049T AT84300049T ATE18197T1 AT E18197 T1 ATE18197 T1 AT E18197T1 AT 84300049 T AT84300049 T AT 84300049T AT 84300049 T AT84300049 T AT 84300049T AT E18197 T1 ATE18197 T1 AT E18197T1
Authority
AT
Austria
Prior art keywords
acid
valponic
aethoxycarbonyloxyaethylester
preparation
formulations containing
Prior art date
Application number
AT84300049T
Other languages
German (de)
English (en)
Inventor
David Ladkani
Ben Zion Weiner
Haim Yellin
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma filed Critical Teva Pharma
Application granted granted Critical
Publication of ATE18197T1 publication Critical patent/ATE18197T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C68/00—Preparation of esters of carbonic or haloformic acids
    • C07C68/06—Preparation of esters of carbonic or haloformic acids from organic carbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/96—Esters of carbonic or haloformic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
AT84300049T 1983-01-05 1984-01-05 1'-aethoxycarbonyloxyaethylester der valponsaeure, seine herstellung und diesen enthaltende formulierungen. ATE18197T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL67623A IL67623A (en) 1983-01-05 1983-01-05 1'-ethoxycarbonyloxyethyl ester of valproic acid,its preparation and pharmaceutical compositions containing it
EP84300049A EP0114720B1 (en) 1983-01-05 1984-01-05 1'-ethoxycarbonyloxyethyl ester of valproic acid, its preparation and formulations containing it

Publications (1)

Publication Number Publication Date
ATE18197T1 true ATE18197T1 (de) 1986-03-15

Family

ID=11053985

Family Applications (1)

Application Number Title Priority Date Filing Date
AT84300049T ATE18197T1 (de) 1983-01-05 1984-01-05 1'-aethoxycarbonyloxyaethylester der valponsaeure, seine herstellung und diesen enthaltende formulierungen.

Country Status (9)

Country Link
US (1) US4595695A (enExample)
EP (1) EP0114720B1 (enExample)
JP (1) JPS59128359A (enExample)
AT (1) ATE18197T1 (enExample)
AU (1) AU558445B2 (enExample)
CA (1) CA1284152C (enExample)
DE (1) DE3460035D1 (enExample)
IL (1) IL67623A (enExample)
ZA (1) ZA838666B (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL67623A (en) * 1983-01-05 1984-09-30 Teva Pharma 1'-ethoxycarbonyloxyethyl ester of valproic acid,its preparation and pharmaceutical compositions containing it
IT1190133B (it) * 1986-06-19 1988-02-10 Chiesi Farma Spa Derivati di acido valproico e di acido (e)-2-valproenoico,procedimento per la loro preparazione e relative composizioni farmaceutiche
CN1649600A (zh) 2002-02-28 2005-08-03 A&D生物科学公司 氟西汀及类似物的糖醛酰胺、苷和原酸酯苷及其应用
US20050107310A1 (en) * 2002-03-19 2005-05-19 Holick Michael F. Carboxylic acid glycuronides, glycosamides and glycosides of quinolones, penicillins, analogs, and uses thereof
US20050255038A1 (en) * 2002-04-12 2005-11-17 A And D Bioscience, Inc. Conjugates comprising cancer cell specific ligands, a sugar and diagnostic agents and uses thereof
CA2484891A1 (en) * 2002-05-07 2003-11-20 A & D Bioscience, Inc. Conjugates comprising central nervous system active drug
US20050215487A1 (en) * 2002-06-27 2005-09-29 Holick Michael F Conjugates comprising an nsaid and a sugar and uses thereof
EP1567674A4 (en) * 2002-11-22 2007-09-26 Univ Johns Hopkins AIM FOR THE THERAPY OF COGNITIVE IMMUNITY
WO2007028030A2 (en) * 2005-09-02 2007-03-08 Picobella, Llc Oncogenic regulatory rnas for diagnostics and therapeutics
US7459280B2 (en) * 2006-02-27 2008-12-02 Picobella, Llc Methods for diagnosing and treating kidney cancer
US7763650B2 (en) * 2006-03-15 2010-07-27 Medipharma S.A. Pharmaceutical compound and method
US20080267977A1 (en) * 2007-04-26 2008-10-30 Friedrich-Alexander University Of Erlangen-Nuremberg Combined immunological agent and sensitizing agent for the treatment of cancer
BRPI0920342A2 (pt) 2008-10-16 2020-06-23 The Johns Hopkins University Uso de um inibidor da proteína vesicular sináptica 2a (sv2a) ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica para melhora da função cognitiva, uso de levitiracetam ou um sal farmaceuticamente aceitável do mesmo, uso de brivaracetam ou um sal farmaceuticamente aceitável do mesmo, uso do seletracetam ou um sal farmaceuticamente aceitável do mesmo
CN109662964A (zh) * 2010-02-09 2019-04-23 约翰斯.霍普金斯大学 用于改善认知功能的方法和组合物
SG11201407310TA (en) * 2012-05-08 2014-12-30 Cellix Bio Private Ltd Compositions and methods for the treatment of neurological disorders
EP3610890A1 (en) 2012-11-14 2020-02-19 The Johns Hopkins University Methods and compositions for treating schizophrenia
CN105142623A (zh) 2013-03-15 2015-12-09 艾吉因生物股份有限公司 用于改善认知功能的方法和组合物
EP2968237A4 (en) 2013-03-15 2016-08-31 Univ Johns Hopkins METHOD AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION
JP6899043B2 (ja) 2015-05-22 2021-07-07 エージンバイオ， インコーポレイテッド レベチラセタムの持続放出性医薬組成物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2442M (fr) * 1962-10-17 1964-04-06 Henry Eugene L'acide dipropylacétique et ses dérivés en tant que nouveuax médicaments dépresseurs du systeme nerveux central.
US3646201A (en) * 1969-07-31 1972-02-29 Liggett & Myers Inc Salicylate carbonate compounds
GB1598568A (en) * 1977-04-19 1981-09-23 Glaxo Lab Ltd Esters of(6r,7r)-3-carbamoyloxymethyl-7-((z)-2-(fur-2-yl)-2-methoxyiminoacetamido)-ceph-3-em-4-carboxylic acid
DE3262698D1 (en) * 1981-11-17 1985-04-25 Kabivitrum Ab Antifibrinolytically active compounds
US4542158A (en) * 1981-12-21 1985-09-17 Merck & Co., Inc. Prodrug esters of diflunisal and related compounds
NZ202721A (en) * 1981-12-21 1985-12-13 Merck & Co Inc Diflunisal derivatives and pharmaceutical compositions
US4426391A (en) * 1982-09-15 1984-01-17 Merck & Co., Inc. [(Alkoxycarbonyl)oxy]alkyl esters of methyldopa
IL67445A (en) * 1982-12-09 1985-11-29 Teva Pharma Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids
IL67623A (en) * 1983-01-05 1984-09-30 Teva Pharma 1'-ethoxycarbonyloxyethyl ester of valproic acid,its preparation and pharmaceutical compositions containing it

Also Published As

Publication number Publication date
IL67623A0 (en) 1983-05-15
EP0114720A1 (en) 1984-08-01
JPS6229423B2 (enExample) 1987-06-25
AU558445B2 (en) 1987-01-29
EP0114720B1 (en) 1986-02-26
DE3460035D1 (en) 1986-04-03
AU2142183A (en) 1984-07-12
US4595695A (en) 1986-06-17
JPS59128359A (ja) 1984-07-24
ZA838666B (en) 1984-07-25
CA1284152C (en) 1991-05-14
IL67623A (en) 1984-09-30

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee