ATE179077T1 - CHELATING AGENT OF THE S3N2 TYPE FOR RADIOACTIVE ISOTOPES, THEIR METAL COMPLEXES AND THEIR USE IN DIAGNOSTICS AND THERAPY - Google Patents

CHELATING AGENT OF THE S3N2 TYPE FOR RADIOACTIVE ISOTOPES, THEIR METAL COMPLEXES AND THEIR USE IN DIAGNOSTICS AND THERAPY

Info

Publication number
ATE179077T1
ATE179077T1 AT94912440T AT94912440T ATE179077T1 AT E179077 T1 ATE179077 T1 AT E179077T1 AT 94912440 T AT94912440 T AT 94912440T AT 94912440 T AT94912440 T AT 94912440T AT E179077 T1 ATE179077 T1 AT E179077T1
Authority
AT
Austria
Prior art keywords
pct
compounds
diagnostics
therapy
type
Prior art date
Application number
AT94912440T
Other languages
German (de)
Inventor
Christoph-Stephan Hilger
Ludger Dinkelborg
Wolfgang Kramp
Hans-Martin Schier
Original Assignee
Diagnostikforschung Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diagnostikforschung Inst filed Critical Diagnostikforschung Inst
Application granted granted Critical
Publication of ATE179077T1 publication Critical patent/ATE179077T1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57536—Endothelin, vasoactive intestinal contractor [VIC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PCT No. PCT/DE94/00370 Sec. 371 Date Mar. 8, 1996 Sec. 102(e) Date Mar. 8, 1996 PCT Filed Mar. 29, 1994 PCT Pub. No. WO94/22492 PCT Pub. Date Oct. 13, 1994This invention relates to new bifunctional chelating agents with intermittent chalcogen atoms, pharmaceuticals containing these compounds, their use in radiodiagnostics and radiotherapy, and methods for the production of these compounds. The compound according to the invention has the general formula (I) M-L wherein M represents a radionuclide of Tc or Re and L a ligand of the general formula (II) B-CO-CR1R2-A-CR3R4-CO-D(II) These new, bifunctional chelating agents with intermittent chalcogen atoms and their coupling products with compounds that accumulate specifically are suited for producing radiopharmaceuticals for diagnostic and therapeutic purposes.
AT94912440T 1993-03-31 1994-03-29 CHELATING AGENT OF THE S3N2 TYPE FOR RADIOACTIVE ISOTOPES, THEIR METAL COMPLEXES AND THEIR USE IN DIAGNOSTICS AND THERAPY ATE179077T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4311022A DE4311022C2 (en) 1993-03-31 1993-03-31 Bifunctional chalcogen atom-interrupted chelating agents of the type S¶3¶N¶2¶ for radioactive isotopes and their metal complexes, processes for their preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
ATE179077T1 true ATE179077T1 (en) 1999-05-15

Family

ID=6484686

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94912440T ATE179077T1 (en) 1993-03-31 1994-03-29 CHELATING AGENT OF THE S3N2 TYPE FOR RADIOACTIVE ISOTOPES, THEIR METAL COMPLEXES AND THEIR USE IN DIAGNOSTICS AND THERAPY

Country Status (12)

Country Link
US (1) US6143275A (en)
EP (1) EP0692980B1 (en)
JP (1) JPH08508262A (en)
KR (1) KR960700761A (en)
AT (1) ATE179077T1 (en)
AU (1) AU692153B2 (en)
CA (1) CA2156641A1 (en)
DE (2) DE4311022C2 (en)
HU (1) HUT73853A (en)
NO (1) NO953866L (en)
NZ (1) NZ263793A (en)
WO (1) WO1994022492A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4310999C2 (en) * 1993-03-31 1996-07-18 Diagnostikforschung Inst Bifunctional chalkogen atom-interrupted chelating agents of the type XN¶1¶S¶1¶X 'for radioactive isotopes and their metal complexes, processes for their preparation and pharmaceutical compositions containing them
DE19652374A1 (en) * 1996-12-04 1998-06-10 Schering Ag Use of endothelin conjugates in therapy, new endothelin conjugates, agents containing them, and processes for their preparation
CN100528241C (en) * 2002-05-06 2009-08-19 恩多塞特公司 Vitamin-targeted imaging agents
SE526214C2 (en) 2003-02-28 2005-07-26 Amersham Biosciences Ab One way to generate metal chelating affinity ligands

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0063946A1 (en) * 1981-04-21 1982-11-03 AMERSHAM INTERNATIONAL plc Diagnosis of kidney function
US4427752A (en) * 1981-05-08 1984-01-24 Ciba-Geigy Corporation Use of isoindoline pigments for photoelectrophoretic imaging
EP0089143A1 (en) * 1982-03-16 1983-09-21 AMERSHAM INTERNATIONAL plc Diagnosis of kidney function
US4980147A (en) * 1984-06-25 1990-12-25 University Of Utah Research Foundation Radiolabeled technetium chelates for use in renal function determinations
ATE66469T1 (en) * 1985-01-14 1991-09-15 Neorx Corp METAL RADIONUCLIDE LABELED PROTEIN FOR DIAGNOSIS AND THERAPY.
DE3762624D1 (en) * 1986-05-28 1990-06-13 Mallinckrodt Inc TECHNETIUM CHELATE FOR DETERMINING THE KIDNEY FUNCTION.
US4861869A (en) * 1986-05-29 1989-08-29 Mallinckrodt, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins
WO1989000557A1 (en) * 1987-07-16 1989-01-26 Cockbain, Julian, Roderick, Michaelson Aminopolycarboxylic acids and derivatives thereof
AU1995392A (en) * 1991-05-08 1992-12-21 Mallinckrodt Medical, Inc. Technetium chelates to be used for determining the renal function
DE69332470D1 (en) * 1992-02-06 2002-12-12 Biosynthema Inc LIGANDS TO IMPROVE METAL CHELATE-GENERATION KINETICS
DE4311023C2 (en) * 1993-03-31 1996-05-02 Diagnostikforschung Inst Bifunctional chalcogen atom-interrupted chelating agents of type XN¶1¶S¶1¶O¶1¶ for radioactive isotopes, their metal complexes, processes for their preparation and pharmaceutical compositions containing them
DE4310999C2 (en) * 1993-03-31 1996-07-18 Diagnostikforschung Inst Bifunctional chalkogen atom-interrupted chelating agents of the type XN¶1¶S¶1¶X 'for radioactive isotopes and their metal complexes, processes for their preparation and pharmaceutical compositions containing them
DE4311021A1 (en) * 1993-03-31 1994-10-27 Diagnostikforschung Inst Bifunctional chelating agents, their technetium and rhenium complexes, processes for their preparation and radiopharmaceutical compositions containing these compounds

Also Published As

Publication number Publication date
HUT73853A (en) 1996-09-30
WO1994022492A1 (en) 1994-10-13
NZ263793A (en) 1997-02-24
NO953866D0 (en) 1995-09-29
DE59408143D1 (en) 1999-05-27
AU6501694A (en) 1994-10-24
DE4311022A1 (en) 1994-10-06
AU692153B2 (en) 1998-06-04
US6143275A (en) 2000-11-07
EP0692980A1 (en) 1996-01-24
EP0692980B1 (en) 1999-04-21
DE4311022C2 (en) 1996-07-11
HU9502867D0 (en) 1995-11-28
NO953866L (en) 1995-11-23
KR960700761A (en) 1996-02-24
JPH08508262A (en) 1996-09-03
CA2156641A1 (en) 1994-10-13

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