ATE16384T1 - PHENYLPIPERAZINYL-PROPANOLS OF HETARYLPENOLS, THEIR PREPARATION AND THERAPEUTIC AGENTS CONTAINING THEM. - Google Patents

PHENYLPIPERAZINYL-PROPANOLS OF HETARYLPENOLS, THEIR PREPARATION AND THERAPEUTIC AGENTS CONTAINING THEM.

Info

Publication number
ATE16384T1
ATE16384T1 AT81110718T AT81110718T ATE16384T1 AT E16384 T1 ATE16384 T1 AT E16384T1 AT 81110718 T AT81110718 T AT 81110718T AT 81110718 T AT81110718 T AT 81110718T AT E16384 T1 ATE16384 T1 AT E16384T1
Authority
AT
Austria
Prior art keywords
phenylpiperazinyl
propanols
preparation
alkyl
carbon atoms
Prior art date
Application number
AT81110718T
Other languages
German (de)
Inventor
Albrecht Dr Franke
Gerd Dr Steiner
Peter C Dr Thieme
Dieter Dr Lenke
Josef Dr Gries
Hans-Juergen Dr Teschendorf
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Application granted granted Critical
Publication of ATE16384T1 publication Critical patent/ATE16384T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Novel (hetarylphenoxy)-(phenylpiperazinyl)-propanols of the formula <IMAGE> I where R1 is hydrogen, amino or alkyl of 1 to 4 carbon atoms, R2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms or alkoxy where alkyl is of 1 to 3 carbon atoms, the phenyl ring can be monosubstituted or disubstituted by R2, and the heterocyclic structure Het. is pyrimidinyl, triazol-1-yl, imidazol-1-yl, pyrazol-3-yl or isoxazol-3-yl, and their physiologically tolerated addition salts with acids, processes for their preparation, and pharmaceutical formulations which contain these compounds and exhibit predominantly hypotensive, sedative, neuroleptic and broncholytic properties.
AT81110718T 1981-01-19 1981-12-23 PHENYLPIPERAZINYL-PROPANOLS OF HETARYLPENOLS, THEIR PREPARATION AND THERAPEUTIC AGENTS CONTAINING THEM. ATE16384T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19813101456 DE3101456A1 (en) 1981-01-19 1981-01-19 PHENYLPIPERAZINYL PROPANOLS OF HETARYLPHENOLS, THEIR PRODUCTION AND THERAPEUTIC AGENTS CONTAINING THEM
EP81110718A EP0056486B1 (en) 1981-01-19 1981-12-23 Phenylpiperazinyl-propanoles of hetarylphenols, their preparation and their pharmaceutical compositions

Publications (1)

Publication Number Publication Date
ATE16384T1 true ATE16384T1 (en) 1985-11-15

Family

ID=6122857

Family Applications (1)

Application Number Title Priority Date Filing Date
AT81110718T ATE16384T1 (en) 1981-01-19 1981-12-23 PHENYLPIPERAZINYL-PROPANOLS OF HETARYLPENOLS, THEIR PREPARATION AND THERAPEUTIC AGENTS CONTAINING THEM.

Country Status (10)

Country Link
US (1) US4428950A (en)
EP (1) EP0056486B1 (en)
JP (1) JPS57139067A (en)
AT (1) ATE16384T1 (en)
CA (1) CA1202305A (en)
DE (2) DE3101456A1 (en)
DK (1) DK19082A (en)
GR (1) GR75401B (en)
IE (1) IE51889B1 (en)
ZA (1) ZA82294B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3101502A1 (en) * 1981-01-19 1982-08-26 Basf Ag, 6700 Ludwigshafen PHENYLPIPERAZINE DERIVATIVES OF HETARYLPHENOLS AND HETARYLANILINES, THEIR PRODUCTION AND THEIR CONTAINING THERAPEUTIC AGENTS
JPS58164583A (en) * 1982-03-18 1983-09-29 Nippon Shinyaku Co Ltd Phenoxypropanolamine derivative
US4728651A (en) * 1985-10-24 1988-03-01 Hoechst-Roussel Pharmaceuticals Inc. Antihypertensive thieno-isoxazoles and -pyrazoles
US5051423A (en) * 1988-07-13 1991-09-24 Schering Ag Derivatized alkanolamines as cardiovascular agents
CA2155759A1 (en) * 1993-03-29 1994-10-13 Bernd Janssen 1-amino-3-phenoxy propane derivatives as modulators of multi-drug resistance
US6025359A (en) * 1996-06-17 2000-02-15 Eli Lilly And Company Drug resistance and multidrug resistance modulators
EP0972766A4 (en) * 1997-01-30 2000-05-03 Senju Pharma Co Hydroquinone derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3577419A (en) * 1969-10-24 1971-05-04 Sandoz Ag 2,6-disubstituted-4-(omega-aminoalkoxy) phenyl pyrimidines
AT317207B (en) * 1971-06-07 1974-08-26 Boehringer Sohn Ingelheim Process for the preparation of new phenylimidazolidinone derivatives and their salts
DE2263211A1 (en) 1972-12-23 1974-07-04 Boehringer Sohn Ingelheim NEW ARYLPIPERAZINE AND PROCESS FOR THEIR PRODUCTION
DE2510781A1 (en) 1975-03-07 1976-09-23 Schering Ag 1000 Berlin Und 46 Imidazolyl alkyl-phenyl - (thio) ethers - active against dermatophytes, yeasts, protozoa bacterial and fungal diseases
US4134983A (en) 1975-03-03 1979-01-16 Merck & Co., Inc. 3-amino-2-or-propoxyaryl substituted imidazoles
DE2926517A1 (en) * 1979-06-30 1981-01-15 Beiersdorf Ag SUBSTITUTED 3-ARYL-PYRAZOLE AND 5-ARYL-ISOXAZOLE AND METHOD FOR THE PRODUCTION THEREOF

Also Published As

Publication number Publication date
IE820080L (en) 1982-07-19
DK19082A (en) 1982-07-20
DE3172852D1 (en) 1985-12-12
DE3101456A1 (en) 1982-09-02
JPS57139067A (en) 1982-08-27
CA1202305A (en) 1986-03-25
EP0056486A2 (en) 1982-07-28
GR75401B (en) 1984-07-13
IE51889B1 (en) 1987-04-15
ZA82294B (en) 1982-12-29
US4428950A (en) 1984-01-31
EP0056486A3 (en) 1982-08-11
EP0056486B1 (en) 1985-11-06

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