ATE161838T1 - NITRO- OR NITROSO-SUBSTITUTED POLYHALOGENATED PHENOLSULFONOPHTALEINS - Google Patents

NITRO- OR NITROSO-SUBSTITUTED POLYHALOGENATED PHENOLSULFONOPHTALEINS

Info

Publication number
ATE161838T1
ATE161838T1 AT92108737T AT92108737T ATE161838T1 AT E161838 T1 ATE161838 T1 AT E161838T1 AT 92108737 T AT92108737 T AT 92108737T AT 92108737 T AT92108737 T AT 92108737T AT E161838 T1 ATE161838 T1 AT E161838T1
Authority
AT
Austria
Prior art keywords
nitro
nitroso
present
phenolsulfonophtaleins
protein error
Prior art date
Application number
AT92108737T
Other languages
German (de)
Inventor
Paul F Corey
Angela A Michaels
Lois J Proud
Michael Salvati
Ronald G Sommer
Robert W Trimmer
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Application granted granted Critical
Publication of ATE161838T1 publication Critical patent/ATE161838T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/04—Five-membered rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6827—Total protein determination, e.g. albumin in urine
    • G01N33/6839—Total protein determination, e.g. albumin in urine involving dyes, e.g. Coomassie blue, bromcresol green
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B11/00—Diaryl- or thriarylmethane dyes
    • C09B11/04—Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
    • C09B11/06—Hydroxy derivatives of triarylmethanes in which at least one OH group is bound to an aryl nucleus and their ethers or esters
    • C09B11/08—Phthaleins; Phenolphthaleins; Fluorescein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Abstract

The present invention provides a novel group of protein error indicators including nitro or nitroso substituent groups in the B and C rings of a partially halogenated triphenylmethane compound. Di-nitro or nitroso substituted protein error indicators of the present invention are represented by the structural formula: <CHEM> wherein: X is -Cl, -Br, -I; Y is -NO2 or -NO; and Z is -Cl, -Br, -I. Mono-nitro or nitroso protein error indicator compounds of the present invention are illustrated by the following formula: <CHEM> wherein: X is -Cl, -Br, -I; Y' is -NO2 or -NO; Y'' is -Cl, -Br, -I; and Z is -Cl, -Br, -I.
AT92108737T 1991-06-06 1992-05-23 NITRO- OR NITROSO-SUBSTITUTED POLYHALOGENATED PHENOLSULFONOPHTALEINS ATE161838T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/710,952 US5187104A (en) 1991-06-06 1991-06-06 Nitro or nitroso substituted polyhalogenated phenolsulfonephthaleins as protein indicators in biological samples

Publications (1)

Publication Number Publication Date
ATE161838T1 true ATE161838T1 (en) 1998-01-15

Family

ID=24856182

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92108737T ATE161838T1 (en) 1991-06-06 1992-05-23 NITRO- OR NITROSO-SUBSTITUTED POLYHALOGENATED PHENOLSULFONOPHTALEINS

Country Status (17)

Country Link
US (1) US5187104A (en)
EP (1) EP0517054B1 (en)
JP (1) JP3157607B2 (en)
KR (1) KR100232439B1 (en)
AT (1) ATE161838T1 (en)
AU (1) AU636540B2 (en)
CA (1) CA2070039A1 (en)
DE (1) DE69223851T2 (en)
DK (1) DK0517054T3 (en)
ES (1) ES2111009T3 (en)
FI (1) FI922588A (en)
GR (1) GR3026262T3 (en)
IE (1) IE921838A1 (en)
IL (1) IL101859A (en)
NO (1) NO922071L (en)
NZ (1) NZ242731A (en)
ZA (1) ZA923804B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5326707A (en) * 1991-11-29 1994-07-05 Miles Inc. Composition and device for urinary protein assay and method of using the same
US5424215A (en) * 1994-02-07 1995-06-13 Miles Inc. Assay for the determination of protein in a biological sample
US5750405A (en) * 1996-03-01 1998-05-12 Bayer Corporation Method for the detection for protein
KR100352837B1 (en) * 2001-05-22 2002-09-16 성홍제 Polyethylene tarpaulin for hose and its manufacturing method and hose made from it
US7459127B2 (en) * 2002-02-26 2008-12-02 Siemens Healthcare Diagnostics Inc. Method and apparatus for precise transfer and manipulation of fluids by centrifugal and/or capillary forces
ATE484747T1 (en) * 2002-08-09 2010-10-15 Arkray Inc TEST PIECE FOR PROTEIN ASSAY
EP1548443A4 (en) * 2002-08-09 2006-09-06 Arkray Inc Test piece for protein assay and process for producing the same
US7094354B2 (en) * 2002-12-19 2006-08-22 Bayer Healthcare Llc Method and apparatus for separation of particles in a microfluidic device
US7125711B2 (en) * 2002-12-19 2006-10-24 Bayer Healthcare Llc Method and apparatus for splitting of specimens into multiple channels of a microfluidic device
US7435381B2 (en) * 2003-05-29 2008-10-14 Siemens Healthcare Diagnostics Inc. Packaging of microfluidic devices
US20040265171A1 (en) * 2003-06-27 2004-12-30 Pugia Michael J. Method for uniform application of fluid into a reactive reagent area
US20040265172A1 (en) * 2003-06-27 2004-12-30 Pugia Michael J. Method and apparatus for entry and storage of specimens into a microfluidic device
US20080257754A1 (en) * 2003-06-27 2008-10-23 Pugia Michael J Method and apparatus for entry of specimens into a microfluidic device
US7347617B2 (en) * 2003-08-19 2008-03-25 Siemens Healthcare Diagnostics Inc. Mixing in microfluidic devices
CN102617410B (en) * 2012-03-15 2013-11-06 长春万成生物电子工程有限公司 Method for purifying 3,4,5,6-tetrahalogenated phenolsulfonphthalein
CN106957247B (en) * 2017-03-16 2020-03-20 长春万成生物电子工程有限公司 Purification method of micro-protein indicator
KR102268024B1 (en) * 2019-09-30 2021-06-23 주식회사 청도제약 A dry test strip for the microalbumin determination in the urine with high sensitivity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH593503A5 (en) * 1973-07-09 1977-12-15 Oce Van Der Grinten Nv
DE2510633C3 (en) * 1975-03-12 1978-07-13 Boehringer Mannheim Gmbh, 6800 Mannheim Diagnostic agent for the detection of protein in body fluids and indicator dyes suitable therefor

Also Published As

Publication number Publication date
EP0517054A1 (en) 1992-12-09
US5187104A (en) 1993-02-16
GR3026262T3 (en) 1998-05-29
FI922588A (en) 1992-12-07
KR100232439B1 (en) 1999-12-01
IL101859A (en) 1998-09-24
KR930000498A (en) 1993-01-15
NZ242731A (en) 1993-12-23
DE69223851T2 (en) 1998-04-16
IL101859A0 (en) 1992-12-30
FI922588A0 (en) 1992-06-04
CA2070039A1 (en) 1992-12-07
IE921838A1 (en) 1992-12-16
DE69223851D1 (en) 1998-02-12
JPH05230054A (en) 1993-09-07
NO922071D0 (en) 1992-05-25
NO922071L (en) 1992-12-07
EP0517054B1 (en) 1998-01-07
AU1804592A (en) 1992-12-17
DK0517054T3 (en) 1998-09-07
ZA923804B (en) 1993-03-10
AU636540B2 (en) 1993-04-29
JP3157607B2 (en) 2001-04-16
ES2111009T3 (en) 1998-03-01

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee