ATE160566T1 - AMPHOTERELIC TRICYCLIC COMPOUNDS AS ANTHISTAMINIC AND ANTIALLERGIC AGENTS - Google Patents

AMPHOTERELIC TRICYCLIC COMPOUNDS AS ANTHISTAMINIC AND ANTIALLERGIC AGENTS

Info

Publication number
ATE160566T1
ATE160566T1 AT93102518T AT93102518T ATE160566T1 AT E160566 T1 ATE160566 T1 AT E160566T1 AT 93102518 T AT93102518 T AT 93102518T AT 93102518 T AT93102518 T AT 93102518T AT E160566 T1 ATE160566 T1 AT E160566T1
Authority
AT
Austria
Prior art keywords
anthistaminic
amphoterelic
same
tricyclic compounds
antiallergic agents
Prior art date
Application number
AT93102518T
Other languages
German (de)
Inventor
Yasuo Ito
Hideo Kato
Shingo Yasuda
Noriyuki Kado
Nobuhiko Iwasaki
Hiroyuki Nishino
Makoto Takeshita
Original Assignee
Hokuriku Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hokuriku Pharmaceutical filed Critical Hokuriku Pharmaceutical
Application granted granted Critical
Publication of ATE160566T1 publication Critical patent/ATE160566T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Novel amphoteric tricyclic compound represented by the following formula: <CHEM> wherein R<1> represents a hydrogen atom or a halogen atom; X represents -O-, -CH2O-, or -OCH2-; and Y represents a C2-C5 alkylene group which may optionally be substituted with a lower alkyl group, and a pharmacologically acceptable salt thereof are disclosed. Also disclosed are a method for preparing the same, a pharmaceutical composition comprising the same useful as an antiallergic agent and an agent for bronchial asthma, and a method for treatment of an allergic disease or bronchial asthma comprising the step of administering the same.
AT93102518T 1992-02-20 1993-02-18 AMPHOTERELIC TRICYCLIC COMPOUNDS AS ANTHISTAMINIC AND ANTIALLERGIC AGENTS ATE160566T1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP6940492 1992-02-20
JP13760292 1992-05-01
JP13760592 1992-05-01
JP27350692 1992-09-18
JP32146792 1992-11-06

Publications (1)

Publication Number Publication Date
ATE160566T1 true ATE160566T1 (en) 1997-12-15

Family

ID=27524183

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93102518T ATE160566T1 (en) 1992-02-20 1993-02-18 AMPHOTERELIC TRICYCLIC COMPOUNDS AS ANTHISTAMINIC AND ANTIALLERGIC AGENTS

Country Status (10)

Country Link
US (1) US5334594A (en)
EP (1) EP0556813B1 (en)
JP (1) JP2974529B2 (en)
KR (1) KR0140504B1 (en)
AT (1) ATE160566T1 (en)
AU (1) AU655869B2 (en)
CA (1) CA2089207C (en)
DE (1) DE69315363T2 (en)
DK (1) DK0556813T3 (en)
ES (1) ES2111086T3 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5801175A (en) * 1995-04-07 1998-09-01 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases and pharmaceutical compositions comprising them
WO1997009330A1 (en) * 1995-09-01 1997-03-13 Hokuriku Seiyaku Co., Ltd. Crystal of hydrate and process for preparation thereof
JP3723927B2 (en) * 2000-07-11 2005-12-07 日本ライナー株式会社 Method for curing epoxy resin in a short time and electromagnetic wave absorption method using cured epoxy resin obtained by the curing method
US7355042B2 (en) * 2001-10-16 2008-04-08 Hypnion, Inc. Treatment of CNS disorders using CNS target modulators
CA2521831A1 (en) * 2003-04-15 2004-10-28 Fujiyakuhin Co., Ltd. Benzoxepino-11-piperidylidene compounds and process for production thereof
US7617820B2 (en) * 2004-06-15 2009-11-17 Smart Parts, Inc. Pneumatic paintball gun

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
NZ228888A (en) * 1988-04-28 1991-12-23 Schering Corp Derivatives of piperidine, piperidylidene and piperazine and pharmaceutical compositions
ZA914764B (en) * 1990-06-22 1992-03-25 Schering Corp Bis-benzo or benzopyrido cyclohepta piperidene,piperidylidene and piperazine compounds,compositions and methods of use
AU2028892A (en) * 1991-05-23 1992-12-30 Schering Corporation Novel benzopyrido piperidylidene compounds, compositions, methods of manufacture and methods of use
WO1993002081A1 (en) * 1991-07-23 1993-02-04 Schering Corporation Novel benzopyrido piperylidene compounds, compositions, methods of manufacture and methods of use

Also Published As

Publication number Publication date
DE69315363T2 (en) 1998-06-25
JPH06192263A (en) 1994-07-12
KR0140504B1 (en) 1998-06-01
ES2111086T3 (en) 1998-03-01
EP0556813A1 (en) 1993-08-25
DK0556813T3 (en) 1998-08-10
KR960017669A (en) 1996-06-17
DE69315363D1 (en) 1998-01-08
JP2974529B2 (en) 1999-11-10
CA2089207A1 (en) 1993-08-21
AU3309793A (en) 1993-08-26
AU655869B2 (en) 1995-01-12
EP0556813B1 (en) 1997-11-26
CA2089207C (en) 1997-04-29
US5334594A (en) 1994-08-02

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner