ATE135907T1 - Stabile arzneimittel mit 3-(hydroxymethyl)-5,5- diphenylhydantoin-dinatrium-phosphatester - Google Patents
Stabile arzneimittel mit 3-(hydroxymethyl)-5,5- diphenylhydantoin-dinatrium-phosphatesterInfo
- Publication number
- ATE135907T1 ATE135907T1 AT90908752T AT90908752T ATE135907T1 AT E135907 T1 ATE135907 T1 AT E135907T1 AT 90908752 T AT90908752 T AT 90908752T AT 90908752 T AT90908752 T AT 90908752T AT E135907 T1 ATE135907 T1 AT E135907T1
- Authority
- AT
- Austria
- Prior art keywords
- diphenylhydantoin
- hydroxymethyl
- dinatrium
- phenytoin
- phosphate esters
- Prior art date
Links
- FELMSRDKUFGXSF-UHFFFAOYSA-L [Na+].[Na+].P(=O)([O-])([O-])O.OCN1C(NC(C1=O)(C1=CC=CC=C1)C1=CC=CC=C1)=O Chemical class [Na+].[Na+].P(=O)([O-])([O-])O.OCN1C(NC(C1=O)(C1=CC=CC=C1)C1=CC=CC=C1)=O FELMSRDKUFGXSF-UHFFFAOYSA-L 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- CXOFVDLJLONNDW-UHFFFAOYSA-N Phenytoin Chemical compound N1C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 CXOFVDLJLONNDW-UHFFFAOYSA-N 0.000 abstract 3
- 230000015556 catabolic process Effects 0.000 abstract 3
- 238000006731 degradation reaction Methods 0.000 abstract 3
- 229960002036 phenytoin Drugs 0.000 abstract 2
- 229940002612 prodrug Drugs 0.000 abstract 2
- 239000000651 prodrug Substances 0.000 abstract 2
- MUTSJHVOFFHGGL-UHFFFAOYSA-N 2-(n-phenylanilino)acetamide Chemical compound C=1C=CC=CC=1N(CC(=O)N)C1=CC=CC=C1 MUTSJHVOFFHGGL-UHFFFAOYSA-N 0.000 abstract 1
- 230000002920 convulsive effect Effects 0.000 abstract 1
- 239000008380 degradant Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurosurgery (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Dental Preparations (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/356,948 US4925860A (en) | 1987-08-05 | 1989-05-25 | Stable pharmaceutical composition of 3-(hydroxymethyl)-5,5-diphenylhydantoin disodium phosphate ester |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE135907T1 true ATE135907T1 (de) | 1996-04-15 |
Family
ID=23403641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90908752T ATE135907T1 (de) | 1989-05-25 | 1990-05-24 | Stabile arzneimittel mit 3-(hydroxymethyl)-5,5- diphenylhydantoin-dinatrium-phosphatester |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US4925860A (de) |
| EP (1) | EP0473687B1 (de) |
| JP (1) | JP3143471B2 (de) |
| KR (1) | KR0143768B1 (de) |
| AT (1) | ATE135907T1 (de) |
| AU (1) | AU632130B2 (de) |
| CA (1) | CA2067122A1 (de) |
| CZ (1) | CZ277918B6 (de) |
| DE (2) | DE69026253T2 (de) |
| DK (1) | DK0473687T3 (de) |
| ES (1) | ES2086404T3 (de) |
| FI (1) | FI101041B (de) |
| HU (1) | HU212944B (de) |
| IE (1) | IE81130B1 (de) |
| IL (1) | IL94504A (de) |
| LU (1) | LU90340I2 (de) |
| MX (1) | MX9203584A (de) |
| MY (1) | MY106190A (de) |
| NL (1) | NL980045I2 (de) |
| NO (1) | NO179124C (de) |
| NZ (1) | NZ233808A (de) |
| PT (1) | PT94161B (de) |
| RU (1) | RU2075973C1 (de) |
| SG (1) | SG64881A1 (de) |
| SK (1) | SK277911B6 (de) |
| WO (1) | WO1990014080A1 (de) |
| ZA (1) | ZA904038B (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU624262B2 (en) * | 1989-08-10 | 1992-06-04 | Warner-Lambert Company | Use of prophenytoin for treating stroke |
| DK0900227T3 (da) | 1996-04-30 | 2002-04-08 | Warner Lambert Co | Forbedret fremgangsmåde til fremstilling af diestere af 2,5-dioxo-4,4-diphenyl-imidazolidin-1-ylmethylphosphorsyre |
| PT986403E (pt) * | 1997-06-13 | 2004-04-30 | Cydex Inc | Composicao com um tempo de vida de armazenagem prolongado compreendendo a ciclodextrina e drogas ou prodrogas que se decompoem em compostos insoluveis em agua |
| WO1999004798A1 (en) * | 1997-07-22 | 1999-02-04 | Warner-Lambert Company | Lyophilized fosphenytoin sodium for parenteral use |
| US6110499A (en) * | 1997-07-24 | 2000-08-29 | Alza Corporation | Phenytoin therapy |
| US6346547B1 (en) | 1999-02-08 | 2002-02-12 | Checkpoint, Genetics, Inc. | N-substituted amino acids, antioxidant pharmaceutical compositions containing n-substituted amino acids and methods for preventing cardiovascular diseases and/or preventing and/or treating antioxidant responsive diseases therewith |
| AU5824800A (en) * | 1999-06-23 | 2001-01-31 | Warner-Lambert Company | Use of fosphenytoin for the treatment of acute neuropathic pain |
| US20060034910A1 (en) * | 2004-08-09 | 2006-02-16 | Sanjay Patel | Pharmaceutical composition for extended release of phenytoin sodium |
| US20070244074A1 (en) * | 2006-04-17 | 2007-10-18 | Sougata Pramanick | Stable parenteral formulation of fosphenytoin sodium |
| KR101303088B1 (ko) * | 2009-02-17 | 2013-09-06 | 한림제약(주) | 3-(히드록시메틸)-5,5-디페닐히단토인 이나트륨 포스페이트에스테르를 함유하는 주사용 약학 조성물 |
| JP5732453B2 (ja) | 2009-06-25 | 2015-06-10 | アルカーメス ファーマ アイルランド リミテッド | Ｎｈ酸性化合物のプロドラッグ |
| US8431576B2 (en) | 2009-06-25 | 2013-04-30 | Alkermes Pharma Ireland Limited | Heterocyclic compounds for the treatment of neurological and psychological disorders |
| US8592427B2 (en) | 2010-06-24 | 2013-11-26 | Alkermes Pharma Ireland Limited | Prodrugs of NH-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives |
| LT2685979T (lt) | 2011-03-18 | 2016-12-12 | Alkermes Pharma Ireland Limited | Injekcinės farmacinės kompozicijos, apimančios vandenyje netirpų antipsichotiką, sorbitano lauratą ir polisorbatą 20 |
| UY34072A (es) | 2011-05-17 | 2013-01-03 | Novartis Ag | Derivados sustituidos de indol |
| AU2012351747B2 (en) | 2011-12-15 | 2016-05-12 | Alkermes Pharma Ireland Limited | Prodrugs of secondary amine compounds |
| ES2764383T3 (es) | 2012-03-19 | 2020-06-03 | Alkermes Pharma Ireland Ltd | Composiciones farmacéuticas que comprenden ésteres de glicerol |
| WO2013142198A1 (en) | 2012-03-19 | 2013-09-26 | Alkermes Pharma Ireland Limited | Pharmaaceutical compositions comprising fatty acid esters |
| CA2867137C (en) | 2012-03-19 | 2020-12-08 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising aripiprazole prodrugs and benzyl alcohol |
| NZ631345A (en) | 2012-09-19 | 2017-06-30 | Alkermes Pharma Ireland Ltd | Pharmaceutical compositions having improved storage stability |
| CN103288877B (zh) * | 2013-05-10 | 2016-03-09 | 安徽省先锋制药有限公司 | 磷苯妥英稳定的有机胺盐及其制备方法和用途 |
| BR112016021535A8 (pt) | 2014-03-20 | 2021-07-20 | Alkermes Pharma Ireland Ltd | kit compreendendo formulações de aripiprazol tendo velocidades de injeção aumentadas útil para o tratamento de uma desordem do sistema nervoso central e uso |
| CA3092335A1 (en) | 2018-03-05 | 2019-09-12 | Alkermes Pharma Ireland Limited | Aripiprazole dosing strategy |
| EP4257120A4 (de) | 2020-12-04 | 2024-08-07 | Sichuan Credit Pharmaceutical Co., Ltd | Feste fosphenytoin-natrium-zusammensetzung, lyophilisierungsverfahren und verwendung der festen fosphenytoin-natrium-zusammensetzung |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4260769A (en) * | 1977-04-22 | 1981-04-07 | Interx Research Corporation | 5,5-Diphenylhydantoins |
-
1989
- 1989-05-25 US US07/356,948 patent/US4925860A/en not_active Expired - Lifetime
-
1990
- 1990-05-24 KR KR1019910701660A patent/KR0143768B1/ko not_active Expired - Lifetime
- 1990-05-24 SG SG1996003778A patent/SG64881A1/en unknown
- 1990-05-24 IE IE187290A patent/IE81130B1/en not_active IP Right Cessation
- 1990-05-24 AU AU56704/90A patent/AU632130B2/en not_active Expired
- 1990-05-24 HU HU905265A patent/HU212944B/hu unknown
- 1990-05-24 RU SU905010404A patent/RU2075973C1/ru active
- 1990-05-24 EP EP90908752A patent/EP0473687B1/de not_active Expired - Lifetime
- 1990-05-24 MY MYPI90000848A patent/MY106190A/en unknown
- 1990-05-24 JP JP02508239A patent/JP3143471B2/ja not_active Expired - Lifetime
- 1990-05-24 AT AT90908752T patent/ATE135907T1/de active
- 1990-05-24 DE DE69026253T patent/DE69026253T2/de not_active Expired - Lifetime
- 1990-05-24 ES ES90908752T patent/ES2086404T3/es not_active Expired - Lifetime
- 1990-05-24 DE DE1999175021 patent/DE19975021I2/de active Active
- 1990-05-24 CA CA002067122A patent/CA2067122A1/en not_active Abandoned
- 1990-05-24 DK DK90908752.0T patent/DK0473687T3/da active
- 1990-05-24 NZ NZ233808A patent/NZ233808A/en unknown
- 1990-05-24 WO PCT/US1990/002733 patent/WO1990014080A1/en not_active Ceased
- 1990-05-25 SK SK2566-90A patent/SK277911B6/sk not_active IP Right Cessation
- 1990-05-25 ZA ZA904038A patent/ZA904038B/xx unknown
- 1990-05-25 PT PT94161A patent/PT94161B/pt not_active IP Right Cessation
- 1990-05-25 IL IL9450490A patent/IL94504A/en not_active IP Right Cessation
- 1990-05-25 CZ CS902566A patent/CZ277918B6/cs not_active IP Right Cessation
-
1991
- 1991-11-21 FI FI915491A patent/FI101041B/fi active Protection Beyond IP Right Term
- 1991-11-22 NO NO914582A patent/NO179124C/no not_active IP Right Cessation
-
1992
- 1992-06-26 MX MX9203584A patent/MX9203584A/es active IP Right Grant
-
1998
- 1998-12-24 NL NL980045C patent/NL980045I2/nl unknown
-
1999
- 1999-01-19 LU LU90340C patent/LU90340I2/fr unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE135907T1 (de) | Stabile arzneimittel mit 3-(hydroxymethyl)-5,5- diphenylhydantoin-dinatrium-phosphatester | |
| ES2122076T3 (es) | Derivados de nor-acidos biliares, procedimiento para su preparacion y utilizacion de estos compuestos como medicamentos. | |
| AU4732989A (en) | Pyrimidines and their pharmaceutical acceptable salts thereof, and their use as medicines | |
| PT99597B (pt) | Processo para a preparacao de derivados do acido hidroxamico que inibem a lipoxigenase | |
| BG92179A (bg) | Метод за получаване на 7-заместена-хепт-6-еноена и -хептаноена киселина и техни производни и междинни съединения | |
| ATE121295T1 (de) | Augentropfenarzneimittel. | |
| NO179671C (no) | Substituerte cykloheksanderivater, anvendelse av disse for fremstilling av legemidler samt legemiddel for behandling type II diabetes og andre sykdommer | |
| ATE147265T1 (de) | Verwendung von retinoiden zur umkehr glucocorticoid-induzierter hautatrophie | |
| NO303715B1 (no) | Stabilt, vandig apparat | |
| NO301767B1 (no) | Salt av clavulansyre | |
| BE893492A (fr) | Procede de preparation d'esters d'acides apovincaminiques, esters ainsi obtenus et compositions pharmaceutiques prepares avec ces esters | |
| ATE179889T1 (de) | Arzneimittel, die ester omega-3 polyungesättigter säuren enthalten und deren verwendung in der topischen behandlung morbider erkrankungen | |
| ES2135500T3 (es) | Producto farmaceutico para el tratamiento de trastornos de la piel. | |
| BR9304151A (pt) | Soluçao de injeçao da mesma, processo para sua produçao, aplicaçao dessa coluçâo e produto farmaceutico para evitar o efeito colateral de oxazafosforina | |
| NZ292388A (en) | S-enantiomers of 2-alkyl substituted pentynoic acid derivatives, preparation and pharmaceutical compositions thereof | |
| GR1001133B (el) | Μέ?οδος παρασκευής στα?ερής σύν?εσης δινατρίου άλατος φωσφορικού εστέρος 3-(υδροξυμε?υλο)-5,5-διφαινυλουδαντοϊνης. | |
| ITMI940696A0 (it) | Derivati dell'acido fosfonico utili nel trattamento delle malattie cardiovascolari | |
| ITMI912027A0 (it) | Derivati dell'eserolina utili per il trattamento delle malattie associate a disordini colinergici, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono | |
| ITMI911842A0 (it) | Derivati dell'eseridina utili per il trattamento delle malattie associate a disordini colinergici, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono |