ATE131158T1 - HETEROCYCLIC CYCLOALKANES WITH AN INHIBITORY EFFECT ON 5-LIPOXYGENASE. - Google Patents
HETEROCYCLIC CYCLOALKANES WITH AN INHIBITORY EFFECT ON 5-LIPOXYGENASE.Info
- Publication number
- ATE131158T1 ATE131158T1 AT90301935T AT90301935T ATE131158T1 AT E131158 T1 ATE131158 T1 AT E131158T1 AT 90301935 T AT90301935 T AT 90301935T AT 90301935 T AT90301935 T AT 90301935T AT E131158 T1 ATE131158 T1 AT E131158T1
- Authority
- AT
- Austria
- Prior art keywords
- optionally substituted
- lipoxygenase
- ring
- alkylene
- substituents
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/08—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/42—Benzopyrazines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Optical Communication System (AREA)
- Electroluminescent Light Sources (AREA)
- Buildings Adapted To Withstand Abnormal External Influences (AREA)
- Pyridine Compounds (AREA)
- Quinoline Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The invention concerns a heterocyclic cycloalkane of the formula I <CHEM> wherein Q is an optionally substituted 6-membered monocyclic or 10-membered bicyclic heterocyclic moiety containing one or two nitrogen atoms; A is (1-6C)alkylene, (3-6C)alkenylene, (3-6C)alkynylene or cyclo(3-6C)alkylene; X is oxy, thio, sulphinyl, sulphonyl or imino; Ar is phenylene which may optionally bear one or two substituents or Ar is an optionally substituted 6-membered heterocyclene moiety containing up to three nitrogen atoms; R<1> is hydrogen, (1-6C)alkyl, (3-6C)alkenyl, (3-6C)alkynyl, cyano-(1-4C)alkyl or (2-4C)alkanoyl, or optionally substituted benzoyl; and R<2> and R<3> together form a (3-6C)alkylene group which, together with the carbon atom to which R<2> and R<3> are attached, defines a ring having 4 to 7 ring atoms, and which ring may bear one or two substituents; or a pharmaceutically-acceptable salt thereof. The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP89400559 | 1989-02-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE131158T1 true ATE131158T1 (en) | 1995-12-15 |
Family
ID=8202930
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT90301935T ATE131158T1 (en) | 1989-02-28 | 1990-02-22 | HETEROCYCLIC CYCLOALKANES WITH AN INHIBITORY EFFECT ON 5-LIPOXYGENASE. |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0385663B1 (en) |
JP (1) | JP2851353B2 (en) |
AT (1) | ATE131158T1 (en) |
AU (1) | AU626989B2 (en) |
CA (1) | CA2010211A1 (en) |
DE (1) | DE69023940T2 (en) |
DK (1) | DK0385663T3 (en) |
ES (1) | ES2080788T3 (en) |
FI (1) | FI901009A0 (en) |
GR (1) | GR3018316T3 (en) |
IL (1) | IL93343A0 (en) |
NO (1) | NO900917L (en) |
NZ (1) | NZ232514A (en) |
PT (1) | PT93288A (en) |
ZA (1) | ZA901042B (en) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5089495A (en) * | 1989-01-30 | 1992-02-18 | Imperial Chemical Industries Plc | Heterocyclic thiazole derivatives and pharmaceutical compositions comprising said derivatives |
IE70521B1 (en) * | 1989-02-28 | 1996-12-11 | Zeneca Pharma Sa | Heterocycles with inhibitory activity of 5-lipoxygenase |
IE911919A1 (en) * | 1990-06-21 | 1992-01-01 | Zeneca Ltd | Bicyclic heterocyclic compounds |
US5227399A (en) * | 1991-02-28 | 1993-07-13 | Merck Frosst Canada, Inc. | Pyranylphenyl naphthalene lactones as inhibitors of leukotriene biosynthesis |
US5281720A (en) * | 1991-02-28 | 1994-01-25 | Merck Frosst Canada, Inc. | Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis |
EP0505122A1 (en) * | 1991-03-21 | 1992-09-23 | Zeneca Limited | Alpha, alpha-dialkylbenzyl derivatives |
EP0570112A1 (en) * | 1992-04-23 | 1993-11-18 | Zeneca Limited | Cycloalkane derivatives |
US5308852A (en) * | 1992-06-29 | 1994-05-03 | Merck Frosst Canada, Inc. | Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis |
US5268379A (en) * | 1992-08-24 | 1993-12-07 | Abbott Laboratories | Ether-containing inhibitors of 5-lipoxygenase |
US5350744A (en) * | 1992-08-27 | 1994-09-27 | Merck Frosst Canada, Inc. | Phenylnaphthalene lactones as inhibitors of leukotriene biosynthesis |
US5426109A (en) * | 1992-08-27 | 1995-06-20 | Merck Frosst Canada, Inc. | Phenylnaphthalene hydroxy acids |
US5428060A (en) * | 1992-08-27 | 1995-06-27 | Merck Frosst Canada, Inc. | Heteroarylnaphthalene lactones as inhibitors of leukotriene biosynthesis |
US5252599A (en) * | 1992-08-27 | 1993-10-12 | Merck Frosst Canada, Inc. | Heteroarylnaphthalene hydroxy acids as inhibitors of leukotriene biosynthesis |
WO1994005638A1 (en) * | 1992-09-02 | 1994-03-17 | Abbott Laboratories | Trans 1,4-diether cyclohexane inhibitors of 5-lipoxygenase |
US5407959A (en) * | 1993-11-12 | 1995-04-18 | Abbott Laboratories | (Trans-1,4-dialkoxycyclohexyl) substituted arylalkylaryl-arylalkenylaryl-, and arylalkynylarylurea inhibitors of 5-lipoxygenase |
US5446062A (en) * | 1993-11-12 | 1995-08-29 | Abbott Laboratories | ((4-alkoxypyran-4-yl) substituted) ether, arylalkyl-, arylalkenyl-, and arylalkynyl)urea inhibitors of 5-lipoxygenase |
US6184226B1 (en) | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
US6548670B1 (en) * | 2001-07-19 | 2003-04-15 | Air Products And Chemicals, Inc. | Methods for preparing 5- and 6-benzyl-functionalized quinoxalines |
US6825221B2 (en) | 2001-10-18 | 2004-11-30 | Allergan, Inc. | Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain |
JP2009523820A (en) * | 2006-01-23 | 2009-06-25 | アミラ ファーマシューティカルス,インコーポレーテッド | 5-Lipoxygenase tricyclic inhibitors |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ213986A (en) * | 1984-10-30 | 1989-07-27 | Usv Pharma Corp | Heterocyclic or aromatic compounds, and pharmaceutical compositions containing such |
US4661596A (en) * | 1985-02-21 | 1987-04-28 | American Home Products Corporation | Quinolinyl (or pyridinyl) methoxy substituted naphthalene compounds as antiallergic agents |
US4839369A (en) * | 1985-04-16 | 1989-06-13 | Rorer Pharmaceutical Corporation | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments |
DE3617183A1 (en) * | 1985-11-16 | 1987-05-27 | Bayer Ag | SUBSTITUTED BENZYL ETHERS |
IL93344A0 (en) * | 1989-02-28 | 1990-11-29 | Ici Plc | Heterocyclic cyclic ethers |
IE70521B1 (en) * | 1989-02-28 | 1996-12-11 | Zeneca Pharma Sa | Heterocycles with inhibitory activity of 5-lipoxygenase |
IE66512B1 (en) * | 1989-02-28 | 1996-01-10 | Ici Plc | Heterocyclic ethers as 5-lipoxygenase inhibitors |
-
1990
- 1990-02-11 IL IL93343A patent/IL93343A0/en unknown
- 1990-02-12 ZA ZA901042A patent/ZA901042B/en unknown
- 1990-02-12 CA CA002010211A patent/CA2010211A1/en not_active Abandoned
- 1990-02-13 NZ NZ232514A patent/NZ232514A/en unknown
- 1990-02-14 AU AU49764/90A patent/AU626989B2/en not_active Ceased
- 1990-02-22 EP EP90301935A patent/EP0385663B1/en not_active Expired - Lifetime
- 1990-02-22 DK DK90301935.4T patent/DK0385663T3/en active
- 1990-02-22 DE DE69023940T patent/DE69023940T2/en not_active Expired - Fee Related
- 1990-02-22 AT AT90301935T patent/ATE131158T1/en not_active IP Right Cessation
- 1990-02-22 ES ES90301935T patent/ES2080788T3/en not_active Expired - Lifetime
- 1990-02-27 NO NO90900917A patent/NO900917L/en unknown
- 1990-02-28 JP JP2046014A patent/JP2851353B2/en not_active Expired - Lifetime
- 1990-02-28 PT PT93288A patent/PT93288A/en not_active Application Discontinuation
- 1990-02-28 FI FI901009A patent/FI901009A0/en not_active Application Discontinuation
-
1995
- 1995-12-07 GR GR950403183T patent/GR3018316T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
FI901009A0 (en) | 1990-02-28 |
AU626989B2 (en) | 1992-08-13 |
NZ232514A (en) | 1992-04-28 |
DK0385663T3 (en) | 1996-03-11 |
DE69023940D1 (en) | 1996-01-18 |
ZA901042B (en) | 1990-10-31 |
ES2080788T3 (en) | 1996-02-16 |
EP0385663A3 (en) | 1991-11-21 |
IL93343A0 (en) | 1990-11-29 |
JPH02268158A (en) | 1990-11-01 |
EP0385663A2 (en) | 1990-09-05 |
DE69023940T2 (en) | 1996-04-25 |
EP0385663B1 (en) | 1995-12-06 |
AU4976490A (en) | 1990-09-06 |
GR3018316T3 (en) | 1996-03-31 |
CA2010211A1 (en) | 1990-08-31 |
NO900917D0 (en) | 1990-02-27 |
PT93288A (en) | 1990-08-31 |
JP2851353B2 (en) | 1999-01-27 |
NO900917L (en) | 1990-08-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE131477T1 (en) | HETEROCYCLIC COMPOUNDS WITH AN INHIBITORY EFFECT ON 5-LIPOXYGENASE | |
ATE131158T1 (en) | HETEROCYCLIC CYCLOALKANES WITH AN INHIBITORY EFFECT ON 5-LIPOXYGENASE. | |
ATE110073T1 (en) | HETEROCYCLIC DERATIVES. | |
DE69026639D1 (en) | Heterocyclic cyclic ethers with an inhibitory effect on 5-lipoxygenase |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |