ATE113040T1 - APPLICATION OF NAPHTHOXAZINES. - Google Patents

APPLICATION OF NAPHTHOXAZINES.

Info

Publication number
ATE113040T1
ATE113040T1 AT90810968T AT90810968T ATE113040T1 AT E113040 T1 ATE113040 T1 AT E113040T1 AT 90810968 T AT90810968 T AT 90810968T AT 90810968 T AT90810968 T AT 90810968T AT E113040 T1 ATE113040 T1 AT E113040T1
Authority
AT
Austria
Prior art keywords
naphthoxazines
application
schaemia
cerebral
stroke
Prior art date
Application number
AT90810968T
Other languages
German (de)
Inventor
Joachim Nozulak
Andre Sauter
Jean-Marie Vigouret
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898928316A external-priority patent/GB8928316D0/en
Priority claimed from DE19904003262 external-priority patent/DE4003262A1/en
Application filed by Sandoz Ag filed Critical Sandoz Ag
Application granted granted Critical
Publication of ATE113040T1 publication Critical patent/ATE113040T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Compounds of formula I <IMAGE> wherein R1, R2, R3 and R4 are as defined in the description, are useful for the treatment of conditions associated with cerebral is schaemia, e.g. stroke.
AT90810968T 1989-12-14 1990-12-11 APPLICATION OF NAPHTHOXAZINES. ATE113040T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898928316A GB8928316D0 (en) 1989-12-14 1989-12-14 Improvements in or relating to organic compounds
DE19904003262 DE4003262A1 (en) 1990-02-03 1990-02-03 Use of naphth:oxazine derivs.

Publications (1)

Publication Number Publication Date
ATE113040T1 true ATE113040T1 (en) 1994-11-15

Family

ID=25889734

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90810968T ATE113040T1 (en) 1989-12-14 1990-12-11 APPLICATION OF NAPHTHOXAZINES.

Country Status (15)

Country Link
US (1) US5190941A (en)
EP (1) EP0433239B1 (en)
JP (1) JPH0825880B2 (en)
KR (1) KR0182276B1 (en)
AT (1) ATE113040T1 (en)
AU (1) AU639512B2 (en)
CA (1) CA2032132A1 (en)
CY (1) CY2065B1 (en)
DE (1) DE69013476T2 (en)
DK (1) DK0433239T3 (en)
ES (1) ES2063328T3 (en)
HK (1) HK1000244A1 (en)
HU (1) HU214591B (en)
IE (1) IE66143B1 (en)
PT (1) PT96178B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0647137B1 (en) * 1992-06-22 2008-08-13 The Regents Of The University Of California Glycine receptor antagonists and the use thereof
DE4329776A1 (en) * 1993-09-03 1995-03-09 Sandoz Ag Naphthoxazines, their manufacture and use
CN102245625A (en) 2008-10-17 2011-11-16 威斯康星旧生研究基金会 Method of making biologically active alpha-beta peptides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4540691A (en) * 1984-04-13 1985-09-10 Nelson Research & Development Co. Dopamine agonists and use thereof
HU193979B (en) * 1984-06-12 1987-12-28 Sandoz Ag Process for producing naphtoxazine derivatives and pharmaceutical compositions containing them
EP0233728A1 (en) * 1986-02-11 1987-08-26 Takeda Chemical Industries, Ltd. 1,4-Benzoxazine derivatives their production and use

Also Published As

Publication number Publication date
IE66143B1 (en) 1995-12-13
DK0433239T3 (en) 1995-01-16
EP0433239B1 (en) 1994-10-19
DE69013476T2 (en) 1995-05-04
ES2063328T3 (en) 1995-01-01
CA2032132A1 (en) 1991-06-15
AU6797590A (en) 1991-06-20
JPH0825880B2 (en) 1996-03-13
HU214591B (en) 1998-04-28
PT96178A (en) 1991-09-30
CY2065B1 (en) 1998-06-12
HU908017D0 (en) 1991-06-28
KR0182276B1 (en) 1999-05-01
IE904497A1 (en) 1991-06-19
EP0433239A1 (en) 1991-06-19
PT96178B (en) 1998-04-30
KR910011261A (en) 1991-08-07
HUT57749A (en) 1991-12-30
HK1000244A1 (en) 1998-02-13
DE69013476D1 (en) 1994-11-24
JPH03271223A (en) 1991-12-03
AU639512B2 (en) 1993-07-29
US5190941A (en) 1993-03-02

Similar Documents

Publication Publication Date Title
MX9102407A (en) 4 ARILPIPERAZINES AND 4-NOVEL ARYLPIPERIDINES.
FI915920A (en) SEROTONINANTAGONISTER.
DE69615682D1 (en) N- (1-ALKYL-5-PHENYL-2,3,4,5-TETRAHYDRO-1-H-BENZO [B] [1,5] -DIAZEPIN-3-YL) -ACETAMIDE
ATE79622T1 (en) 1,4-DIAZEPINS.
ATE144498T1 (en) PREPARATION OF SUBSTITUTED PIPERIDINES
DE69424009D1 (en) Use of (S) - (-) - alpha-ethyl-2-oxo-1-pyrrolidine acetamide for the manufacture of a medicament for the treatment of anxiety
ES2193241T3 (en) NEW N-2-OXO2.3.4.5-TETRAJODRP-1H-1,5-BENZODIAZEPIN-3-IL) -3-AMIDAS.
DE69130497D1 (en) New use of 1-alpha-hydroxylated-19-nor-vitamin-D compounds for the treatment of psoriasis
DK0459256T3 (en) Oxazolidionones
ATE15882T1 (en) USE OF 1,3-DIALKYL-CYCLOHEXANE COMPOUNDS AS A COSMETIC OIL COMPONENT.
ES2194102T3 (en) NEW N- (2,4-DIOXO-2,3,4,5-TETRAHIDRO-1H-1,5-BENZODIAZEPIN-3-IL) -3-AMIDAS.
ATE113040T1 (en) APPLICATION OF NAPHTHOXAZINES.
DE59104132D1 (en) Use of 2-n-alkyl-1,2-benzisothiazolin-3-ones as technical microbicides.
DE68911237D1 (en) Nonionic triiodine compounds and contrast agents containing them.
DE3783070T2 (en) PHENYL URINE.
ES2095726T3 (en) SUBSTITUTED PIPERAZINES, THEIR PREPARATION PROCEDURE AND THE PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
DK0623131T3 (en) Alkyl derivatives of trazodone with CNS activity
DE69131058D1 (en) Use of a therapeutic composition for the treatment of bronchitis
ATE165089T1 (en) THIOCARBAMOYL COMPOUNDS AS MICROBICIDES
DE58909089D1 (en) Use of myricetin-3-0-beta-D-glucuronide as a medicine.
DE3767940D1 (en) PYRANDE DERIVATIVES.
FI882388A0 (en) 4-SUBSTITUERAD 10-CYANMETHYLENPYRROLO / 4,3-E / BENZOAZEPIN.
SU1783806A1 (en) 7- (1-HYDROXY-1-TRIFTOROMETHYL-2,2,2-TRIFTOROTHYL) - the OPERATOR and 5- (1-HYDROXY-1-METHOXYCARBONYL-2,2,2-TRIFTORETHYL) -8-TRIBUTYLOLOVOOXYCHINOLINES IN THE QUALITY IS in the quality of the application.
IT1255474B (en) 1,4-benzothiazine derivatives having calcium antagonist activity

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEFA Change of the company name
REN Ceased due to non-payment of the annual fee