ATE101524T1 - PHARMACEUTICALLY ACTIVE COMPOUND CONTAINING HIRUDIN AND ACTIVATOR OF PLASMINOGEN. - Google Patents
PHARMACEUTICALLY ACTIVE COMPOUND CONTAINING HIRUDIN AND ACTIVATOR OF PLASMINOGEN.Info
- Publication number
- ATE101524T1 ATE101524T1 AT89810676T AT89810676T ATE101524T1 AT E101524 T1 ATE101524 T1 AT E101524T1 AT 89810676 T AT89810676 T AT 89810676T AT 89810676 T AT89810676 T AT 89810676T AT E101524 T1 ATE101524 T1 AT E101524T1
- Authority
- AT
- Austria
- Prior art keywords
- plasminogen
- activator
- active compound
- compound containing
- pharmaceutically active
- Prior art date
Links
- 102000007625 Hirudins Human genes 0.000 title abstract 2
- 108010007267 Hirudins Proteins 0.000 title abstract 2
- WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 title abstract 2
- 229940006607 hirudin Drugs 0.000 title abstract 2
- 102000013566 Plasminogen Human genes 0.000 title 1
- 108010051456 Plasminogen Proteins 0.000 title 1
- 239000012190 activator Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 208000007536 Thrombosis Diseases 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 102000001938 Plasminogen Activators Human genes 0.000 abstract 1
- 108010001014 Plasminogen Activators Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 229940127126 plasminogen activator Drugs 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
- A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
There is provided a pharmaceutical composition comprising as component A a plasminogen activator and as component B hirudin together with a pharmaceutically acceptable carrier. The pharmaceutical composition can be used for the prophylaxis and therapy of thrombosis or diseases caused by thrombosis.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB888822147A GB8822147D0 (en) | 1988-09-21 | 1988-09-21 | Pharmaceutically active combination |
| EP89810676A EP0365468B1 (en) | 1988-09-21 | 1989-09-12 | Pharmaceutically active combination comprising a plasminogen activator and hirudin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE101524T1 true ATE101524T1 (en) | 1994-03-15 |
Family
ID=10643975
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89810676T ATE101524T1 (en) | 1988-09-21 | 1989-09-12 | PHARMACEUTICALLY ACTIVE COMPOUND CONTAINING HIRUDIN AND ACTIVATOR OF PLASMINOGEN. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5126134A (en) |
| EP (1) | EP0365468B1 (en) |
| JP (1) | JPH02121934A (en) |
| KR (1) | KR0149001B1 (en) |
| AT (1) | ATE101524T1 (en) |
| AU (1) | AU628854B2 (en) |
| CA (1) | CA1336493C (en) |
| DE (1) | DE68913132T2 (en) |
| DK (1) | DK463989A (en) |
| GB (1) | GB8822147D0 (en) |
| IE (1) | IE62434B1 (en) |
| IL (1) | IL91706A (en) |
| NZ (1) | NZ230691A (en) |
| PH (1) | PH27420A (en) |
| ZA (1) | ZA897173B (en) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8927722D0 (en) * | 1989-12-07 | 1990-02-07 | British Bio Technology | Proteins and nucleic acids |
| US5837808A (en) * | 1991-08-20 | 1998-11-17 | Baxter International Inc. | Analogs of hirudin |
| WO1993014199A1 (en) * | 1992-01-13 | 1993-07-22 | Abbott Laboratories | A pump-1 catalyzed method of making low molecular weight urokinase-type plasminogen activator |
| ZA936478B (en) * | 1992-09-03 | 1994-09-30 | Regeneron Pharma | Dorsal tissue affecting factor and compositions |
| CA2124330A1 (en) * | 1992-09-28 | 1994-04-14 | Akiko Sukesada | Novel hirudine variant, process for producing the same, and anticoagulant containing the same as active ingredient |
| DE4323754C1 (en) * | 1993-07-15 | 1994-12-01 | Gruenenthal Gmbh | New bifunctional urokinase derivs and related plasmids |
| US5972648A (en) * | 1993-09-28 | 1999-10-26 | Japan Energy Corporation | Hirudin analogs, methods of manufacture thereof and anticoagulant compositions having these as active ingredients |
| US5510330A (en) * | 1994-03-25 | 1996-04-23 | Boehringer Mannheim Gmbh | Combinations of thrombolytically active proteins and non-heparin anticoagulants, and uses thereof. |
| US5759542A (en) * | 1994-08-05 | 1998-06-02 | New England Deaconess Hospital Corporation | Compositions and methods for the delivery of drugs by platelets for the treatment of cardiovascular and other diseases |
| DE4440892A1 (en) * | 1994-11-17 | 1996-05-23 | Gruenenthal Gmbh | Proteins with fibrinolytic and anticoagulant properties |
| US7759506B2 (en) | 2002-02-25 | 2010-07-20 | Diffusion Pharmaceuticals Llc | Bipolar trans carotenoid salts and their uses |
| GB2394498B (en) * | 2002-10-23 | 2006-08-09 | Engineering Business Ltd | Mounting of offshore structures |
| GB0306547D0 (en) * | 2003-03-21 | 2003-04-23 | Engineering Business Ltd | Apparatus for creating a local reduction in wave height |
| US20110002978A1 (en) | 2003-06-17 | 2011-01-06 | Harrison Roger G | Enzyme prodrug cancer therapy selectively targeted to tumor cells or tumor vasculature and methods of production and use thereof |
| EP1635764A4 (en) * | 2003-06-17 | 2009-10-21 | Roger G Harrison | Conjugate for the specific targeting of anticancer agents to cancer cells and production thereof |
| EP1703895A2 (en) * | 2004-01-13 | 2006-09-27 | Vasogenix Pharmaceuticals, Inc. | Controlled release cgrp delivery composition for cardiovascular and renal indications |
| EP1703915A2 (en) * | 2004-01-13 | 2006-09-27 | Vasogenix Pharmaceuticals, Inc. | Methods of using cgrp for cardiovascular and renal indications |
| US20090023643A1 (en) * | 2004-01-13 | 2009-01-22 | Vasogenix Pharmaceuticals, Inc. | Methods For Treating Acute Myocardial Infarction By Administering Calcitonin Gene Related Peptide And Compositions Containing The Same |
| DE602005011019D1 (en) * | 2004-08-03 | 2008-12-24 | Ihc Engineering Business Ltd | D DEVICE |
| GB0503083D0 (en) * | 2005-02-15 | 2005-03-23 | Engineering Business Ltd | Launch and recovery apparatus and method |
| KR101315904B1 (en) | 2005-02-24 | 2013-10-08 | 디퓨젼 파마슈티컬즈 엘엘씨 | Trans Carotenoids, Their Synthesis, Formulation and Uses |
| GB2428656B (en) | 2005-08-01 | 2009-08-05 | Engineering Business Ltd | Gangway apparatus |
| GB2434823A (en) * | 2006-02-06 | 2007-08-08 | Engineering Business Ltd | Transport and installation of offshore structures |
| BRPI0810647A2 (en) | 2007-04-13 | 2014-11-04 | Diffusion Pharmaceuticals Llc | "Use of Bipolar Trans Carotenoids as a Pretreatment and in the Treatment of Peripheral Vascular Disease". |
| US20090214469A1 (en) * | 2008-02-25 | 2009-08-27 | Jeffrey Gold | Methods and Compositions for the Treatment of Sepsis |
| CN102458110A (en) | 2009-06-22 | 2012-05-16 | 扩散药品有限公司 | Diffusion enhancing compounds and their use alone or with thrombolytic agents |
| EP2575487B1 (en) | 2010-06-02 | 2017-10-18 | Diffusion Pharmaceuticals Llc | Oral formulations of bipolar trans carotenoids |
| US9987241B2 (en) | 2014-09-25 | 2018-06-05 | The Board Of Regents Of The University Of Oklahoma | Enzyme conjugate and prodrug cancer therapy |
| KR20230014850A (en) | 2016-03-24 | 2023-01-30 | 디퓨젼 파마슈티컬즈 엘엘씨 | Use of bipolar trans carotenoids with chemotherapy and radiotherapy for treatment of cancer |
| WO2020032951A1 (en) | 2018-08-09 | 2020-02-13 | The Board Of Regents Of The University Of Oklahoma | Antimalarial enzyme conjugates, kits containing same, and methods of producing and using same |
| US11613744B2 (en) | 2018-12-28 | 2023-03-28 | Vertex Pharmaceuticals Incorporated | Modified urokinase-type plasminogen activator polypeptides and methods of use |
| JP7604376B2 (en) | 2018-12-28 | 2024-12-23 | バーテックス ファーマシューティカルズ インコーポレイテッド | Modified urokinase-type plasminogen activator polypeptides and methods of use - Patents.com |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8003402A (en) * | 1980-06-11 | 1982-01-04 | Leuven Res & Dev Vzw | NEW PLASMINOGEN ACTIVATOR AND PHARMACEUTICAL PREPARATION WITH THROMBOLYTIC ACTION. |
| DE3342139A1 (en) * | 1983-11-22 | 1985-05-30 | Ciba-Geigy Ag, Basel | DESULFATOHIRUDINE, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS |
| JPS61112018A (en) * | 1984-11-06 | 1986-05-30 | Mitsubishi Chem Ind Ltd | fibrinolytic enhancer |
| DE3544318A1 (en) * | 1985-12-14 | 1987-06-19 | Behringwerke Ag | AGENT FROM A PLASMIN INHIBITOR AND A PLASMINOGEN ACTIVATOR FOR THE TREATMENT OF THROMBOSES |
| JP2739050B2 (en) * | 1988-01-28 | 1998-04-08 | ヘキスト薬品工業株式会社 | Anticoagulant |
| DE3804600A1 (en) * | 1988-02-13 | 1989-08-24 | Basf Ag | MIXTURE OF A THROMBOLYTICALLY ACTIVE AND ANTITHROMBOTIC SUBSTANCE |
-
1988
- 1988-09-21 GB GB888822147A patent/GB8822147D0/en active Pending
-
1989
- 1989-09-12 EP EP89810676A patent/EP0365468B1/en not_active Revoked
- 1989-09-12 DE DE68913132T patent/DE68913132T2/en not_active Revoked
- 1989-09-12 AT AT89810676T patent/ATE101524T1/en not_active IP Right Cessation
- 1989-09-13 AU AU41352/89A patent/AU628854B2/en not_active Ceased
- 1989-09-18 US US07/408,836 patent/US5126134A/en not_active Expired - Fee Related
- 1989-09-19 PH PH39253A patent/PH27420A/en unknown
- 1989-09-19 CA CA000611903A patent/CA1336493C/en not_active Expired - Fee Related
- 1989-09-19 NZ NZ230691A patent/NZ230691A/en unknown
- 1989-09-20 KR KR1019890013492A patent/KR0149001B1/en not_active Expired - Fee Related
- 1989-09-20 IE IE301589A patent/IE62434B1/en not_active IP Right Cessation
- 1989-09-20 DK DK463989A patent/DK463989A/en not_active Application Discontinuation
- 1989-09-20 IL IL91706A patent/IL91706A/en not_active IP Right Cessation
- 1989-09-20 JP JP1242356A patent/JPH02121934A/en active Pending
- 1989-09-20 ZA ZA897173A patent/ZA897173B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR0149001B1 (en) | 1998-10-15 |
| AU4135289A (en) | 1990-03-29 |
| NZ230691A (en) | 1992-03-26 |
| PH27420A (en) | 1993-06-21 |
| GB8822147D0 (en) | 1988-10-26 |
| AU628854B2 (en) | 1992-09-24 |
| JPH02121934A (en) | 1990-05-09 |
| IL91706A (en) | 1997-07-13 |
| CA1336493C (en) | 1995-08-01 |
| EP0365468B1 (en) | 1994-02-16 |
| US5126134A (en) | 1992-06-30 |
| DE68913132D1 (en) | 1994-03-24 |
| IE893015L (en) | 1990-03-21 |
| DK463989D0 (en) | 1989-09-20 |
| DE68913132T2 (en) | 1994-07-07 |
| DK463989A (en) | 1990-03-22 |
| KR900004349A (en) | 1990-04-12 |
| EP0365468A1 (en) | 1990-04-25 |
| ZA897173B (en) | 1990-09-26 |
| IL91706A0 (en) | 1990-06-10 |
| IE62434B1 (en) | 1995-02-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| RZN | Patent revoked |