AT49829B - Process for the preparation of carboxyalkylsalicylosalicylic acids. - Google Patents

Process for the preparation of carboxyalkylsalicylosalicylic acids.

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Publication number
AT49829B
AT49829B AT49829DA AT49829B AT 49829 B AT49829 B AT 49829B AT 49829D A AT49829D A AT 49829DA AT 49829 B AT49829 B AT 49829B
Authority
AT
Austria
Prior art keywords
acids
carboxyalkylsalicylosalicylic
preparation
salicylic acid
carboxyalkylsalicylic
Prior art date
Application number
Other languages
German (de)
Inventor
Alfred Dr Einhorn
Original Assignee
Alfred Dr Einhorn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfred Dr Einhorn filed Critical Alfred Dr Einhorn
Application granted granted Critical
Publication of AT49829B publication Critical patent/AT49829B/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

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  Verfahren zur Darstellung von Karboxyalkylsalizylosalizylsäuren. 



   Es wurde gefunden, dass sich die Karboxyalkylsalizylosalizylsäuren in Abänderung des Verfahrens des Stammpatentes Nr.   49828 darstellen fassen, wenn man   an Stelle der Chlorkohlensäureester hier der Karboxyalkylsalizylsäurechloride oder Salizylsäuredialkyldikarbonate 
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 gibt man 15 g Phosphorentachlorid, erwärmt drei Stunden unter Rückflss, destilliert das Losungsmittel ab und unterwirft den Rückstand dfr fraktionierten Destillation im Varkuum. 
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   essig 1.5 g rohe Karboxyäthylsalizylosalizylsäure aus, welche nach dem Umkristallisieren aus   Benzolbei117 Cschmilzt. 



     Beispiel   11 : Eine Lösung von 4 g Salizylsäurediäthyldikarbonat (I). R. P. Nr.   11 7'-) (i7)   und 1.9 g Salizylsäure in Pyridin lässt man etwa drei Tage stehen und giesst sie dann 
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  Process for the preparation of carboxyalkylsalicylosalicylic acids.



   It has been found that the carboxyalkylsalizylosalicylic acids can be represented in a modification of the process of the parent patent No. 49828 if the carboxyalkylsalicylic acid chlorides or salicylic acid dialkyl dicarbonates are used instead of the chlorocarbonic acid esters
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 15 g of phosphorus tachloride are added, the mixture is heated under reflux for three hours, the solvent is distilled off and the residue is subjected to fractional distillation in a vacuum.
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   vinegar 1.5 g of crude carboxyethylsalizylosalicylic acid which, after recrystallization from benzene, melts at 117 C.



     Example 11: A solution of 4 g of salicylic acid diethyl bicarbonate (I). R. P. No. 11 7'-) (17) and 1.9 g of salicylic acid in pyridine are left to stand for about three days and then poured
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Claims (1)

PATENT-ANSPRUCH : Abänderung des Verfahrens des Stammpatentes Nr. 49828, darin bestehend, dass man an Stelle von Chloralkylkarbonaten die Chloride der Karboxyalkylsalizylsäuren oder Salizylsäuredialkyldikarbonate auf Salizylsäure in Gegenwart tertiärer nasen einwirken lässt. PATENT CLAIM: Modification of the process of the parent patent no. 49828, consisting in the fact that instead of chloroalkyl carbonates, the chlorides of carboxyalkylsalicylic acids or salicylic acid dialkyl dicarbonates are allowed to act on salicylic acid in the presence of tertiary noses.
AT49829D 1908-10-16 1909-10-11 Process for the preparation of carboxyalkylsalicylosalicylic acids. AT49829B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE49828X 1908-10-16
DE49829X 1908-10-30

Publications (1)

Publication Number Publication Date
AT49829B true AT49829B (en) 1911-09-11

Family

ID=25749086

Family Applications (1)

Application Number Title Priority Date Filing Date
AT49829D AT49829B (en) 1908-10-16 1909-10-11 Process for the preparation of carboxyalkylsalicylosalicylic acids.

Country Status (1)

Country Link
AT (1) AT49829B (en)

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