AT348128B - METHOD OF PREPARING THE NEW 4'-DEOXYADRIAMYCINE - Google Patents

METHOD OF PREPARING THE NEW 4'-DEOXYADRIAMYCINE

Info

Publication number
AT348128B
AT348128B AT68278A AT68278A AT348128B AT 348128 B AT348128 B AT 348128B AT 68278 A AT68278 A AT 68278A AT 68278 A AT68278 A AT 68278A AT 348128 B AT348128 B AT 348128B
Authority
AT
Austria
Prior art keywords
sep
deoxyadriamycine
preparing
new
desc
Prior art date
Application number
AT68278A
Other languages
German (de)
Other versions
ATA68278A (en
Inventor
Sergio Penco
Federico Arcamone
Marco Aurelio Di
Original Assignee
Farmaceutici Italia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB39471/75A external-priority patent/GB1511559A/en
Application filed by Farmaceutici Italia filed Critical Farmaceutici Italia
Application granted granted Critical
Publication of AT348128B publication Critical patent/AT348128B/en
Publication of ATA68278A publication Critical patent/ATA68278A/en

Links

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

  

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<tb> 
<tb> mitVerbindung <SEP> Wirkung <SEP> auf <SEP> L1 <SEP> - <SEP> Leukämie <SEP> 
<tb> 210
<tb> Dosis
<tb> mg/kg <SEP> mittlere <SEP> Über- <SEP> lange <SEP> Zeit <SEP> toxische <SEP> Todeslebenszeit <SEP> % <SEP> Überlebende <SEP> fälle <SEP> 
<tb> (nach <SEP> 60 <SEP> Tagen)
<tb> Adriamycin <SEP> 2,

   <SEP> 5 <SEP> 145 <SEP> - <SEP> - <SEP> 
<tb> 5 <SEP> 155 <SEP> 2/20
<tb> 10 <SEP> 163 <SEP> 2/20 <SEP> 3/18
<tb> 4'-Deoxy- <SEP> 1 <SEP> 155
<tb> adriamycin <SEP> 2 <SEP> 162 <SEP> - <SEP> - <SEP> 
<tb> 4 <SEP> 177 <SEP> 2/10
<tb> 5 <SEP> 133 <SEP> 1/10 <SEP> 6/10
<tb> 10 <SEP> 66 <SEP> - <SEP> 10/10
<tb> 
 
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<tb> 
<tb> LeukämieVerbindung <SEP> Wirkung <SEP> auf <SEP> transplantierte <SEP> Gross-Leukämie <SEP> 
<tb> Dosis <SEP> mittlere <SEP> Über- <SEP> lange <SEP> Zeit <SEP> toxische <SEP> Todesmg/kg <SEP> lebenszeit <SEP> % <SEP> Überlebende <SEP> fälle <SEP> 
<tb> (nach <SEP> 45 <SEP> Tagen)
<tb> Adriamycin <SEP> 3, <SEP> 5 <SEP> 183
<tb> 4, <SEP> 5 <SEP> 200 <SEP> - <SEP> - <SEP> 
<tb> 5, <SEP> 5 <SEP> 216 <SEP> 3/10 <SEP> - <SEP> 
<tb> 4'-Deoxy- <SEP> 1, <SEP> 75 <SEP> 200 <SEP> - <SEP> - <SEP> 
<tb> adriamycin <SEP> 2,

   <SEP> 25 <SEP> 233 <SEP> 1/10
<tb> 2, <SEP> 75 <SEP> 233 <SEP> - <SEP> 1/9
<tb> 
 
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<tb> 
<tb> CDE-MauseVerbindung <SEP> Wirkung <SEP> auf <SEP> P@@@-Leukämie
<tb> 388
<tb> Dosis <SEP> mittlere <SEP> Überlebenszeit
<tb> mg/kg <SEP> %
<tb> Adriamycin <SEP> 2, <SEP> 5 <SEP> 218
<tb> 5 <SEP> 209
<tb> 10 <SEP> 264
<tb> 4'-Deoxyadria- <SEP> 2 <SEP> 204
<tb> mycin <SEP> 4 <SEP> 218
<tb> 6 <SEP> 236
<tb> 8 <SEP> 245
<tb> 
 
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<tb> 
<tb> CD-MäusenVerbindung <SEP> Wirkung <SEP> auf <SEP> festes <SEP> Sarkom <SEP> 180
<tb> Dosis <SEP> mg/kg <SEP> Tumorgewicht <SEP> g <SEP> T/C <SEP> % <SEP> (*)
<tb> Adriamycin <SEP> 1, <SEP> 6 <SEP> 0, <SEP> 890 <SEP> 52
<tb> 2,0 <SEP> 0,875 <SEP> 51
<tb> 4'-Deoxyadria- <SEP> 0, <SEP> 8 <SEP> 0, <SEP> 810 <SEP> 47
<tb> mycin <SEP> 1, <SEP> 0 <SEP> 0,

   <SEP> 790 <SEP> 46
<tb> 




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<tb>
<tb> with connection <SEP> effect <SEP> on <SEP> L1 <SEP> - <SEP> leukemia <SEP>
<tb> 210
<tb> dose
<tb> mg / kg <SEP> mean <SEP> over- <SEP> long <SEP> time <SEP> toxic <SEP> lifetime <SEP>% <SEP> survivors <SEP> cases <SEP>
<tb> (after <SEP> 60 <SEP> days)
<tb> Adriamycin <SEP> 2,

   <SEP> 5 <SEP> 145 <SEP> - <SEP> - <SEP>
<tb> 5 <SEP> 155 <SEP> 2/20
<tb> 10 <SEP> 163 <SEP> 2/20 <SEP> 3/18
<tb> 4'-Deoxy- <SEP> 1 <SEP> 155
<tb> adriamycin <SEP> 2 <SEP> 162 <SEP> - <SEP> - <SEP>
<tb> 4 <SEP> 177 <SEP> 2/10
<tb> 5 <SEP> 133 <SEP> 1/10 <SEP> 6/10
<tb> 10 <SEP> 66 <SEP> - <SEP> 10/10
<tb>
 
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<tb>
<tb> leukemia connection <SEP> effect <SEP> on <SEP> transplanted <SEP> gross leukemia <SEP>
<tb> dose <SEP> medium <SEP> over- <SEP> long <SEP> time <SEP> toxic <SEP> death mg / kg <SEP> lifetime <SEP>% <SEP> survivors <SEP> cases <SEP>
<tb> (after <SEP> 45 <SEP> days)
<tb> Adriamycin <SEP> 3, <SEP> 5 <SEP> 183
<tb> 4, <SEP> 5 <SEP> 200 <SEP> - <SEP> - <SEP>
<tb> 5, <SEP> 5 <SEP> 216 <SEP> 3/10 <SEP> - <SEP>
<tb> 4'-Deoxy- <SEP> 1, <SEP> 75 <SEP> 200 <SEP> - <SEP> - <SEP>
<tb> adriamycin <SEP> 2,

   <SEP> 25 <SEP> 233 <SEP> 1/10
<tb> 2, <SEP> 75 <SEP> 233 <SEP> - <SEP> 1/9
<tb>
 
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<tb>
<tb> CDE mouse connection <SEP> Effect <SEP> on <SEP> P @@@ - leukemia
<tb> 388
<tb> dose <SEP> mean <SEP> survival time
<tb> mg / kg <SEP>%
<tb> Adriamycin <SEP> 2, <SEP> 5 <SEP> 218
<tb> 5 <SEP> 209
<tb> 10 <SEP> 264
<tb> 4'-Deoxyadria- <SEP> 2 <SEP> 204
<tb> mycin <SEP> 4 <SEP> 218
<tb> 6 <SEP> 236
<tb> 8 <SEP> 245
<tb>
 
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<tb>
<tb> CD mouse connection <SEP> Effect <SEP> on <SEP> solid <SEP> sarcoma <SEP> 180
<tb> dose <SEP> mg / kg <SEP> tumor weight <SEP> g <SEP> T / C <SEP>% <SEP> (*)
<tb> Adriamycin <SEP> 1, <SEP> 6 <SEP> 0, <SEP> 890 <SEP> 52
<tb> 2.0 <SEP> 0.875 <SEP> 51
<tb> 4'-Deoxyadria- <SEP> 0, <SEP> 8 <SEP> 0, <SEP> 810 <SEP> 47
<tb> mycin <SEP> 1, <SEP> 0 <SEP> 0,

   <SEP> 790 <SEP> 46
<tb>

Claims (1)

EMI6.5 EMI6.6 <Desc/Clms Page number 7> EMI7.1 EMI7.2 EMI7.3 EMI6.5 EMI6.6 <Desc / Clms Page number 7> EMI7.1 EMI7.2 EMI7.3
AT68278A 1975-09-26 1978-02-01 METHOD OF PREPARING THE NEW 4'-DEOXYADRIAMYCINE AT348128B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB39471/75A GB1511559A (en) 1975-09-26 1975-09-26 Anthracycline glycosides
AT707276A AT347582B (en) 1975-09-26 1976-09-23 METHOD FOR PRODUCING THE NEW 4'-DEOXYDAUNOMYCIN

Publications (2)

Publication Number Publication Date
AT348128B true AT348128B (en) 1978-06-15
ATA68278A ATA68278A (en) 1978-06-15

Family

ID=25603547

Family Applications (1)

Application Number Title Priority Date Filing Date
AT68278A AT348128B (en) 1975-09-26 1978-02-01 METHOD OF PREPARING THE NEW 4'-DEOXYADRIAMYCINE

Country Status (1)

Country Link
AT (1) AT348128B (en)

Also Published As

Publication number Publication date
ATA68278A (en) 1978-06-15

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Legal Events

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EIH Change in the person of patent owner
ELJ Ceased due to non-payment of the annual fee
REN Ceased due to non-payment of the annual fee