AT13748U1 - atomizer - Google Patents

Abstract

An atomizer (1) for dispensing and in particular for atomizing a formulation (2), in particular a powder, is proposed. A simple construction and a simple-to-use operation are made possible, in particular, by the atomizer having a mouthpiece (8) with an associated cover (10), so that opening and / or closing the cover (10) cause a release medium, in particular air, to pass through aspirating and / or pressurizing a dispenser, tensioning a spring element (49), and / or further rotating a preferably annular reservoir (3) containing a plurality of cans of the formulation.

Description

isieirechischei föfeütawi AT13 748U1 2014-08-15

description

ATOMIZERS

The present invention relates to an atomizer according to the preamble of claim 1.

In particular, the present invention relates to the delivery and atomization of a formulation for inhalation or other medical or therapeutic purposes. The present invention particularly preferably relates to the delivery of medical, pharmaceutical and / or therapeutic formulations, which in particular comprise or consist of at least one active substance.

In particular, the present invention relates to an inhaler. During the atomization, an aerosol or a spray cloud is produced, which, in particular for inhalation, has very fine, solid and / or liquid particles, preferably in the range from 1 to 10 μm.

The formulation is preferably a powder. The invention therefore particularly preferably relates to a powder inhaler. The term " formulation " preferably also includes liquids according to the invention, but the term " liquid " in a broader sense is understood to include, among others, solutions, suspensions, suspensions (mixture of solution and suspension), dispersions, mixtures thereof, or the like.

The following description relates primarily to the delivery and atomization of a powdered formulation or a powder inhaler, although the invention is not limited thereto, but in particular for other inhalers, nebulizers or dispensers can be used.

More particularly, the present invention relates to a nebulizer having a predosed formulation. In particular, the individual cans are contained in separate containers, such as chambers, blister bags, inserts, capsules or the like, and can be removed and atomized individually.

In principle, there are passive and active atomizers. In the passive type, the formulation is expelled by the airflow generated by the user inhaling or inhaling. In the active type, the formulation is expelled independently of inhalation during inhalation, and the delivery may be triggered by the inhalation process, in particular by so-called breath triggering. In particular, a stream of delivery medium, such as air or other gas, is generated by the nebulizer or inhaler itself to deliver the formulation. For this purpose, the atomizer has a dispenser, such as an air pump or a pressurized gas container. The advantage of the active type over the passive type is that in the active type very easily reproducible release and atomization of the formulation can be achieved independently of the user.

EP 0 950 423 B1 discloses an active dispenser for media, in particular powder, with a compressed air pump, namely a piston pump, which is integrated in the dispenser. The dispenser has a blister disc with circular blister pockets containing the powder. For actuating or opening the individual blister pockets, the housing part is moved in the axial direction.

EP 1 132 104 B1 discloses an active dispenser for delivering a medium containing at least one pharmaceutical agent from a blister strip. The dispenser has a pump for a fluid, in particular air, for ejecting the medium, an impact tip for establishing a fluid connection between the pump and a blister pocket and a lateral actuator which positions both a blister pocket and the impact tip after actuation Ejects the medium causes. The dispenser also has a spring, which during a first operating step under tension 1/73

and during a second actuating step, can be released into a relaxed position by releasing a latch, which spring sequentially causes the blister bag to be positioned relative to the impact tip, the blister pocket is opened by the impact tip and air is supplied to the blister pocket, so that the medium is ejected.

WO 91/06333 A1 discloses an active dispenser having a hollow cylindrical reservoir comprising a number of axially extending chambers containing powders. By collapsing the dispenser in the axial direction, air is compressed in a piston pump and finally passed through the respective chamber, whereby the corresponding dose of powder is ejected.

US 5,533,502 A discloses a passive powder inhaler with an annular reservoir, in particular a blister, with a number of containers for powder. The reservoir is rotatably held by a carrier in the inhaler. The carrier can be rotated to select the next container by means of an axially projecting knob and moved to pierce the container in the axial direction. However, this does not allow easy operation. In fact, the user must hold the button or carrier in the axially staggered state during inhalation. After being released, the carrier with the reservoir returns to its axial home position away from the piercing elements due to the spring force.

WO 2005/037353 A1 discloses a passive inhaler with a strip of blisters which can be pierced by means of a pivotable actuator. The actuator comprises a mouthpiece and a device for piercing blisters. The blister strip may be advanced by pivoting the actuator. In one embodiment, the actuator is connected to a cap that covers the mouthpiece such that a blister is pierced when the cap is opened and timed such that as the cap closes, the next unused blister moves into the positional aperture in the housing becomes. The actuator is lifted when the cover is closed, so that a compact structure can not be achieved. If the actuator were not raised, the next blister would be pierced due to the advancement of the blister strip when closing the cover.

It is the object of the present invention to provide an atomizer, which can be very simple, especially intuitive, can be operated while it is simple and inexpensive and built a compact structure, especially a low overall height, allows or has.

The above object is achieved by an atomizer according to claim 1. Further features are the subject of the dependent claims.

In a first aspect of the present invention, which can also be carried out independently, the atomizer has a drive or a translation, so that by the movement for opening and / or closing the cover a preferably axial movement is generated, through which next container is opened, the memory is moved to a container and / or advanced, a spring accumulator is tensioned, a dispenser is triggered, in particular air is sucked, and / or a counter or other device of the atomizer is actuated. This results in a simple, compact construction, especially when the drive or the gear is arranged in an annular arrangement around the reservoir or containers.

In a second aspect of the present invention, the cover of the nebulizer mouthpiece is coupled to a dispenser such as a pump and / or an energy storage such as a spring accumulator such that opening and / or closing of the cover activates the dispenser and / or generates energy and this is stored in the energy storage. In particular, when opening the cover a donor medium, preferably air, sucked by means of the dispenser and / or pressurized. 2/73

Austrian fiäfeü disguises AT 13 748 U1 2014-08-15

Alternatively or additionally, energy generated by opening and / or closing the cover is preferably stored by tensioning the spring accumulator. This allows a very simple, in particular intuitive, operation of the atomizer. This also makes it possible to keep the construction particularly simple and thus cost-effective. For example, there may not need to be a separate actuator for operating the dispenser or pump and / or tensioning the spring accumulator or the like.

In a third, also independently practicable aspect of the present invention, the nebulizer has a closable chamber for receiving medicaments independently of the reservoir. This results in a simple, compact construction with higher drug capacity.

Further aspects, features, characteristics and advantages of the present invention will become apparent from the claims and the following description of preferred embodiments with reference to the drawings, in which: Fig. 1 Fig. 2 Fig. 3 Fig. 4b Fig. 4c Fig. 4d Fig. 4e Fig. 5 Fig. 6 Fig. 7 [0030] Figs Fig. 8 Fig. 9 Fig. 11 shows a schematic section through a proposed atomizer according to a first embodiment in a transport position; shows a schematic section through the atomizer of Figure 1 in the activated state. shows a perspective view of the atomizer in the open or activated state; a schematic view of a sliding guide in the atomizer of FIG. 1; a schematic view of the open or cut atomizer of Figure 1 with a detent mechanism. shows a schematic section through the atomizer of Figure 1 with a locking device. a perspective view of a control ring of the locking device of FIG. 4c shows; shows another schematic section through the atomizer with the locking device of FIG. 4c; shows a schematic section through the atomizer 1 of Figure 1 after dispensing or atomization. shows a schematic section through a proposed atomizer according to a second embodiment in the transport position; shows a schematic section through the atomizer of Figure 6 in the activated or opened state. shows a schematic section through a proposed atomizer according to a third embodiment in the open or activated state; shows a schematic view of a proposed atomizer 1 according to a fourth embodiment in the transport position; shows a schematic section through the atomizer of Figure 9 in the activated, compressed state. shows a schematic section through a proposed atomizer according to a fifth embodiment in the transport position; shows a schematic section through the atomizer of Figure 12 in the unlocked state. 3/73

FIG. 14 shows a schematic section through the atomizer of FIG. 12 in the activated, compressed state; FIG. Fig. 15 shows a schematic section through a proposed atomizer according to a sixth embodiment in the transport position; 16 shows a schematic section through the atomizer according to FIG. 15 in the unlocked state; FIG. Fig. 17 shows a schematic view of a connecting element of the atomiser according to Fig. 16; Fig. 18 Fig. 19 Fig. 21 Fig. 22 Fig. 22 Fig. 23 Fig. 24 Fig. 25 Fig. 26 Fig. 27 Fig. 28 schematically illustrates another detail of Fig. 16; a side view of a detail of the atomizer according to FIG. 15 with a counting device in the transport position; Fig. 19 shows a side view of the atomizer in the unlocked state; shows a perspective view of the atomizer of Figure 15 with a clock; shows a perspective view of the atomizer of FIG. 15 with a drug container; shows a schematic section through a proposed atomizer according to an eighth embodiment in the transport position; shows a schematic section through the atomizer of Figure 23 in the open or activated state. a schematic view of a transport device of the atomizer according to Fig 23 shows; shows a schematic view of a part of a proposed atomizer according to a ninth embodiment; Fig. 26 shows a view corresponding to Fig. 26 of the atomizer in an activated state; FIG. 29 is a schematic sectional view of the atomizer of FIG. 28; FIG. 29 is a schematic sectional view of the operation of a proposed atomizer according to a tenth embodiment;

In the figures, the same reference numerals are used for the same or similar parts, even if the associated description is not repeated. In particular, the same or corresponding advantages and properties are thereby obtained.

Fig. 1 shows in a schematic section a proposed atomizer 1 according to a first embodiment in the transport position. It is in particular a preferably portable inhaler, particularly preferred for aerosol therapy.

The atomizer 1 is designed so that it dispenses a formulation 2, preferably powder, and atomized. In particular, the atomizer 1 can be used for a formulation 2 in the sense explained above.

The formulation 2 is preferably predosed into individual doses, which can be dispensed successively from the nebulizer 1, in particular for inhalation.

The nebulizer 1 has a reservoir 3 or is designed such that it can contain such. If necessary, the reservoir 3 can be inserted into the atomizer 1 and optionally replaced for repeated use of the atomizer 1.

The reservoir 3 has a number of containers 4, each containing a dose of the 4/73 asterreidBsd! "Pitwiarot AT13 748U1 2014-08-15

Formulation 2 included. The containers 4 can, for. B. blister pockets, but preferably contain inserts 28 with the respective dose of the formulation 2. The reservoir 3 is preferably constructed rigid and / or annular. In particular, the reservoir 3 or the containers 4 form / form an annular arrangement, the containers 4 preferably being distributed over the outer circumference of the reservoir 3.

The atomizer 1 is preferably an atomizer of the active type. In the embodiment illustrated by way of example, the atomiser 1 preferably has a dispensing device 5 for a dispensing medium, in particular air or another gas, for dispensing the formulation 2. The dispensing device 5 is constructed in particular as a pump, particularly preferably as an air pump, or is designed in some other way for conveying the dispensing medium.

In particular, the dispensing device 5 has a pump chamber 6, which is preferably formed by a bellows 7 and / or another element of the dispensing device 5, is limited and / or can be varied.

When using the dispenser 5 in particular ambient air can be sucked in as a discharge medium and pressurized. Using the delivery medium, formulation 2, i. H. a dose of the formulation 2, from a container 4 upon actuation or use of the atomizer 1, in particular only after it has been triggered accordingly ejected. However, the dispenser 5 may, in principle, also produce, provide and / or pressurize air, another gas or even liquid as a delivery medium in any other way, so as to be able to formulate the formulation 2, particularly as an aerosol or spray with fine (solid and / or liquid) particles to eject.

The nebulizer 1 preferably has an end or mouthpiece 8 for dispensing the formulation 2, in particular to a user or patient (not shown). In the following, only the term " mouthpiece " used. However, it may also be any other end piece for administering or delivering the formulation 2, especially if the nebulizer 1 is not used as an inhaler.

A discharge opening of the mouthpiece 8 is preferably provided with a grid 9 or other protective element, in particular damage to the atomizer 1, z. As the reservoir 3 or the container 4, which is caused by external influences or the like can be prevented and / or the ejection of other parts, larger particles or the like is prevented.

The atomizer 1 preferably has a cover 10 associated with the mouthpiece 8, which in particular is manually movable so that the mouthpiece 8 can be opened and closed. Fig. 1 shows the cover 10 in the closed, d. H. the mouthpiece 8 covering, condition. Fig. 2 shows in a similar sectional view of the activated atomizer 1, d. H. the nebulizer 1 ready for inhalation, with the cover 10 open, d. H. freely accessible mouthpiece 8.

The cover 10 is movable, in particular at right angles to the dispensing direction 11 indicated in FIG. 2, in particular slidable and / or pivotable.

In the exemplary embodiment, the cover 10 is preferably pivotable or rotatable about a central axis 12 of the nebulizer 1 or the annular arrangement of the reservoir 3 or the containers 4 or about an axis of rotation of the reservoir 3.

The atomizer 1 or its housing 13 is preferably at least substantially rotationally symmetrical, in particular with respect to the axis 12, and / or constructed such that it is at least substantially flat or disc-shaped and in particular has substantially the shape of a circular disk. However, other geometric and structural solutions and arrangements are also possible.

The cover 10 can preferably be moved on a tangent to the housing 13 of the atomizer 1 or along a circumference of the atomizer 1. The cover 10 5/73

In particular, AT 13 748 U1 2014-08-15 extends essentially around the circumference, in particular along a peripheral section of the atomizer 1.

Fig. 3 shows a preferred construction, in particular a flat, disc-shaped and / or round embodiment of the atomizer 1. It can also be seen that the cover 10 has a peripheral portion of the atomizer 1 of preferably at least 90 °, in particular substantially about 150 ° to 170 °, covering or overlapping, and this in particular both in the circumferential direction and from a flat side over the peripheral portion to the other. Again, however, other structural solutions and designs are possible.

In the fully opened position illustrated in Figs. 2 and 3, in the illustrated embodiment, the cover 10 is preferably rotated or pivoted about 150 ° to 180 ° with respect to the closed transport position shown in Fig. 1 , However, other tilt angles are also possible.

Alternatively, the cover 10 may be formed, for example, as a slide and / or aperture and guided, for example, by the housing 13 or the mouthpiece 8, stored or held.

The cover 10 is preferably coupled to the dispensing device 5 such that by opening and / or closing and in particular simply by opening the cover 10, the dispensing device 5 is operated or actuated and in particular the dispensing medium (in particular ambient air) sucked by the dispensing device 5 becomes. Alternatively or additionally, the dispensing medium may be pressurized by the opening and / or closing movement of the cover 10. In this case, the operation is very simple and intuitive, since the operation of the dispensing device 5 is intuitive by the opening and / or closing of the cover 10 and in particular no additional operation of any other actuator is required.

The atomizer 1 or the dispensing device 5 preferably has an energy store, in particular a spring store, in the illustrated embodiment in the form of a spring 14. The cover 10 is preferably coupled to the energy store such that by opening and / or closing the cover 10th Energy is generated and stored in the energy storage. In particular, the opening and / or closing-particularly preferably only the closing-of the cover 10 causes energy to be stored by tensioning the spring accumulator or the spring 14.

The energy store or the spring store can drive various devices and / or serve different purposes and serves in particular to drive the dispensing device 5 or to pressurize the dispensing medium or to displace it from the pump chamber 6, so that the dispensing medium through a container and the appropriate dose of Formulation 2 is expelled and atomized in the desired manner. The dispensing medium is preferably pressurized only during or for the purpose of dispensing Formulation 2. However, theoretically, this can also be done beforehand, in which case a valve device or the like (not shown) is provided so that, in particular, the premature delivery of the delivery medium and the formulation 2 is prevented before the actual desired delivery and atomization.

The energy store is preferably in connection with the dispensing device 5 or forms part of it. Particularly preferably, the energy store or the spring store surrounds the dispensing device 5 or is arranged in this or integrated therein.

In the embodiment shown by way of example, the spring 14 is arranged at an axial extension with respect to the direction of the pump or the pumping action or behind the pumping chamber 6 or the bellows 7. In this case, the spring 14 preferably acts as a compression spring which compresses or compresses the pumping chamber 6 or the bellows 7 or, for example, displaces a piston (not shown) such that the size of the pumping chamber 6 is reduced or the dispensing medium contained therein is compressed - d. H. under pressure - and thereby the delivery of the release medium is effected. 6/73

The dispensing device 5 and / or the energy store is / are particularly preferably arranged in the interior of the annular arrangement of the reservoir 3 or the containers 4, thus in particular at least substantially in the center of the housing 13 , Preferably, the dispenser 5 and the energy storage in the region of the axis 12 or about the axis 12 around, preferably concentric therewith, arranged.

Due to the inventive arrangement of the dispensing device 5 and / or the energy storage or other devices within the annular arrangement of the reservoir 3 or the containers 4, the dispenser 5 and / or the energy storage can also in the axial direction via the reservoir 3 or The containers 4 also extend or, for example, be arranged in the transport position shown in FIG. 1 in a position axially displaced from the main or ring plane of the reservoir 3.

The arrangement of the dispenser 5 and / or the energy storage inside the annular arrangement of the reservoir 3 or the containers 4 or other device leads to a particularly compact construction and in particular a particularly low height in the axial direction of the atomizer first

The pivot axis of the cover 10 preferably corresponds to the axis 12 of the annular arrangement of the reservoir 3 or the containers 4, wherein the reservoir 3 is preferably rotatable about this axis, as will be described in more detail below.

The atomizer 1 preferably has a translation or a drive 15, in particular for the aforementioned preferred coupling of the cover 10 with the dispenser 5 and / or the energy storage. Alternatively or additionally, the translation, which will be referred to as transmission 15 below, also drive and / or operate other devices or perform other functions.

Preferably, the transmission 15 - partially or completely - within the annular arrangement of the reservoir 3 or the containers 4 is arranged. This in turn contributes to a compact construction of the atomizer 1.

The transmission 15 is preferably driven by moving the cover 10 and is in particular directly or indirectly coupled thereto.

Particularly preferably, the gear 15 generates from the movement for opening and / or closing the cover 10, an axial movement, in particular with respect to the annular arrangement and / or the axis 12. More preferably, the axial movement is on or along the axis 12 or in parallel. The term " axial movement " should be understood that at least one component of the movement generated by the transmission 15 on the power transmission side in the aforementioned axial direction.

The axial movement that can be generated by the transmission 15 is particularly preferred for opening the next container 4, for moving and / or advancing the reservoir 3 or the containers 4, for tensioning the spring accumulator, for actuating the dispenser 5 , in particular for sucking in air, and / or for actuating another device of the atomizer 1, such as a counting device used. Preferably, the transmission 15 has different transmission ratios on the power transmission side for driving various devices.

The transmission 15 preferably comprises at least one thread, in particular a rotatable threaded sleeve 16, which particularly preferably has an internal thread 17 and / or an external thread 18.

The thread or the threaded sleeve 16 is preferably coupled or connected directly or indirectly to the cover 10 and / or arranged coaxially with the pivot axis of the cover 10 or forms this. The rotation of the cover 10 causes in particular directly the rotation of the threaded sleeve 16th

In the illustrated embodiment, the dispenser 5, and in particular also the energy storage, may / may be provided by the transmission 15, preferably in the axial direction

AT13 748U1 2014-08-15 in particular via the internal thread 17, driven or actuated. The internal thread 17 is preferably in engagement with an internal engagement part 19, which in particular comprises a complementary threaded portion or other projections, engagement surfaces or the like, so that by rotating the threaded sleeve 16 an axial movement of the non-co-rotating engagement member 19 is effected, which with the Dispensing device 5 or the energy storage is in communication.

The spring 14 is mounted in particular at one end on the engaging part 19, which preferably forms a corresponding spring support or a spring abutment, for. B. using an end plate or the like, and is coupled at the other end to the movable end of the bellows 7 or other pumping element of the dispenser 5. Again, however, other solutions in terms of construction are possible. The gear 15 or the engagement member may also act only directly on the bellows 7 or other pumping element and / are additionally coupled only indirectly or not at all with the spring 14.

Starting from the transport position shown in Fig. 1, the engagement member 19 is moved on the one hand in the axial direction when opening the cover 10, d. H. it performs the preferred axial movement, on the other hand a preferably interlocking and / or releasable connection between the engagement member 19 and the dispenser 5 and / or the spring accumulator - for example by means of at least one barrier arm 20 - translates the axial movement and in particular leads to that the pump chamber 6 increases in the axial direction and preferably sucks in ambient air, wherein the bellows 7 is elongated or enlarged in the axial direction and / or - in particular when the axial end position is reached - a preferably centrally or axially arranged actuator 21 is released and / or is moved in the axial direction outwards, as shown in the end position in Fig. 2. The tensioned spring 14 is preferably moved together with the engagement portion 19 and an axial end of the bellows 7 in the axial direction.

During the subsequent actuation of the actuating element 21, in particular by being pressed in radially inwards, the discharge is initiated and the formulation 2 is atomized from an adjacent container 4. In particular, the connection between the engaging part 19 on the one hand and the at least one locking arm 20 or the dispenser 5 and / or the energy storage on the other hand, in particular by the fact that at least one engaging element 22, the at least one locking arm 20 in a non-engaging position (in the illustrated Embodiment radially inward) springs. The return or spring force of the spring accumulator or the tensioned spring 14 then causes the bellows 7 to collapse and the pump chamber 6 is reduced, whereby the discharge medium contained in the pump chamber 6 (in particular ambient air) is pressurized and displaced, so that Formulation 2 is ejected and atomized in the desired manner, as will be explained in more detail below.

As an alternative or in addition to the thread, theoretically also another control cam, run-on surface, inclined plane or another gear connection can be used, in particular the sequence of movements described hereinbefore, a sequence of movements described hereinafter and / or any other sequence of movements is achieved.

The nebulizer 1 preferably has a transport device 23, so that the reservoir 3, preferably stepwise, to the next container 4 or a container 4 further advanced or rotated, and preferably a connecting device 24, through which in particular the containers. 4 can be individually connected to the dispenser 5 and / or in particular the containers 4 can be opened individually.

Preferably, the transport device 23 and / or the connecting device 24 by the opening and / or closing of the cover 10, in particular via the transmission 15, driven or operated. Particularly preferably, an axial movement generated by the gear 15 is used here. 8/73

In the illustrated embodiment, the operation of the transport device 23 and the operation of the connecting device 24 - ie the advancement of the reservoir 3 to the next container 4 and the opening of the next container 4 and / or the connection to the dispenser 5 - combined or coupled. However, these operations can also be controlled independently or in particular via separate outputs of the transmission 15 or separate drive chains.

Preferably, the combined drive of the transport device 23 and the connecting device 24 is achieved via an outer engagement part 25, which engages in the external thread 18 of the threaded sleeve 16 - in particular via a corresponding threaded portion, a sliding surface or the like. This engagement member 25 is in particular rotatably connected to the preferably annular reservoir 3 or is formed by this. For example, the engagement member 25 may form a closed inner ring of the reservoir 3. However, this is not essential. The reservoir 3 may for example also directly with the gear 15, in particular the external thread 18 of the threaded sleeve 16, via corresponding sliding surfaces or the like are engaged.

The reservoir 3 is preferably locked at its outer circumference to a free rotation with the threaded sleeve 16 or the external thread 18 about the axis 12 and this in particular by a sliding guide, which is produced for example in cooperation with the housing 13.

The rotation of the threaded sleeve 16 or the external thread 18 (or another control cam) leads to an axial movement of the non-co-rotating engagement part 25 and thus also the reservoir 3. For example, the reservoir 3 with the containers 4 of the in Fig 1 in the transport position during or as a result of the opening of the cover 10 - d. H. by means of the gear 15 - moved in the axial direction in the position shown in Fig. 2. This axial or lifting movement takes place in the illustrated embodiment in the opposite direction to the axial movement for actuating the dispensing device 5 (in particular aspiration of ambient air), but can also take place in the same direction.

Only after the actuating element 21 has been actuated - d. H. after dispensing and atomising the formulation 2 from a container 4 - the cover 10 is closed again. The closing of the cover 10 and the rotation of the threaded sleeve 16 cause the reservoir 3 again performs the opposite axial or stroke movement. In the course of this axial movement and / or during the opposite axial movement when opening the cover 10, the sliding guide causes the advancing or further rotation of the reservoir 3 to a container 4, d. H. to the next container 4.

Fig. 4a illustrates a possible construction of the sliding guide or a control groove or control cam 26, which is preferably formed by the inner wall of the housing 13, so that the desired, preferably alternating, axial movement of the reservoir 3 and the stepwise further rotation of the reservoir 3 to in each case a container 4 are performed. This combined movement is achieved in particular by the alternately axially and diagonally extending sections of the control cam 26, in which, for example, a projection of the reservoir 3 engages radially. However, other radially inner and / or axial mechanisms are also possible.

In the illustrated embodiment, the outer engagement member 25 and the aforementioned slide guide form the transport device 23 or components thereof. The sliding guide or the transport mechanism is designed in particular in the manner of a ballpoint pen mechanism (axial reciprocation leads to gradual further rotation). However, there are also other structural solutions possible, in particular the gradual advancement or further rotation of the reservoir 3 to cause a container 4 - particularly preferably by the axial movement and / or the rotation of a transmission component, such as the threaded sleeve 16. 9/73

In an alternative embodiment shown in Fig. 4b, the transport device 23 may alternatively or in addition to the slide or the control cam 26 also have a detent mechanism or pawl mechanism 27, in particular a gradual advancing or further rotation allows the reservoir 3, which is shown in the drawing open or truncated. In particular, the detent mechanism 27 is formed between the outer engagement part 25 and the annular reservoir 3 so that these two can be rotated relative to one another by the corresponding detent steps in one direction.

The detent mechanism 27 has in the illustrated embodiment, in particular a detent 27a, in which a transport arm 27b can engage. Particularly preferred is a radial locking engagement. In principle, however, this can also be done in the axial direction. The detent mechanism 27 is preferably formed on the inside and / or in a circle around the reservoir 3. The transport arm 27b can be moved by the delivery device 5, in particular the gear 15, particularly preferably alternately. In the illustrated embodiment, the transport arm 27b is directly or indirectly connected to the threaded sleeve 16, in particular formed on the outer engagement part 25. Preferably, the transporting arm 27b is elastically biased towards the latch 27a, in particular due to its own elasticity, so that the desired locking engagement is produced. More preferably, a number of transporting arms 27b are provided so that the desired reliable stepwise movement of the reservoir 3 is achieved by reciprocating or rotating the cover 10 or the threaded sleeve 16.

A preferred construction of the connecting device 24 will be explained in more detail below. For better understanding, however, a preferred embodiment of the reservoir 3 will first be explained in more detail.

There are various possibilities for the construction and the design of the reservoir 3 and the containers 4. For example, it may be a blister arrangement, which is optionally combined with a carrier or the like. The individual containers 4 are formed in this case, for example, by blister pockets.

Particularly preferably, the containers 4 are formed by inserts 28 which are received in preferably separate, in particular radially extending guides or receiving chambers 29 of the reservoir 3. In particular, each insert 28 is preferably displaceable or movable in the radial direction.

In the illustrated embodiment, the inserts 28, the receiving chambers 29, the mouthpiece 8 and / or the dispensing device 11 are in particular radially aligned. Theoretically, however, one can also use a different orientation, for example in the axial direction.

The receiving chambers 29 are preferably provided on the outer periphery of the reservoir 3 or the annular arrangement with openings 30 which are preferably closed in the unused state or in the delivery state, in particular sealed or otherwise closed or covered. A corresponding sealing foil or the like is not shown in the figures for the sake of simplicity. In the delivery state, the receiving chambers 29, which contain the inserts 28, each hermetically sealed, in particular liquid-tight and possibly also gas-tight. The reservoir 3 is produced in particular from diffusion-tight plastic and / or is optionally provided with a diffusion-tight outer packaging.

The inserts 28 each have a storage chamber 31 which contains the dose or formulation 2 of the respective insert 28 and which in particular was filled at the factory with the formulation 2 during the production of the reservoir 3 or the atomizer 1. The channel 31 is preferably followed by a channel 32 in the insert 28 for dispensing the formulation 2, which may, if necessary, pass into or form a nozzle (not shown). 73

Therefore, preferably with their storage chambers 31 the containers 4 for the formulation 2.

For the delivery of the formulation 2, the respective container 4 is opened. In the illustrated embodiment, this is preferably done at the discharge end by the respective insert 28, in particular through the opening 30, partially moved out of its receiving chamber 29 and thereby a seal or the like (not shown) is pressed radially outward. Thus, the receiving chamber 29 or the opening 30 is opened and the channel 32 is released. For example, the sealing foil or the like (not shown) closing the respective opening 30 is torn away from the insert 28, or another closure or cover element closing the respective opening 30 is displaced from the insert 28, opened, pushed away or otherwise removed.

The preferred radial displacement of the insert 28 for opening the respective receiving chamber 29 is preferably carried out in the illustrated embodiment by means of the connecting device 24 or the transport device 23, in particular by a finger 33 or another actuator of the connecting device 24 in particular in the axial direction the receiving chamber 29 can penetrate in the region of the radial inner end of the respective insert 28 and in particular by a corresponding sliding surface (on the finger 33 and / or the insert 28) performs the desired radial outward movement of the insert 28.

The penetration of the finger 33 is possible, for example, because the reservoir 3 has a sufficiently thin wall or a predetermined breaking point in the penetration area. Alternatively, the reservoir 3 may also include an opening or the like which is sealed, capped, or capped, and which may be opened or penetrated by the finger 33.

Fig. 1 shows on the left side in section a still closed receiving chamber 29 with an insert 28, which has not been moved radially. Fig. 2 shows the receiving chamber 29, which is already open on the outlet side, with the insert 28, which has already been moved radially and protrudes from the opening 30.

In this embodiment, the connection device 24 has a connection element 34, with which a fluidic connection is made to the respective container 4 for the delivery of the delivery medium, in particular such that the delivery medium, for example through a delivery channel 35 shown, from the delivery device 5 via the connecting element 32 of the respective container 4 - d. H. the respective insert 28 or its storage chamber 31 - for delivery and in particular for atomization of the corresponding dose of formulation can be supplied.

The fluidic connection is preferably also made by the axial movement of the reservoir 3 relative to the housing 13 or the connecting element 34. In particular, the finger 33 initially engages axially in the corresponding receiving chamber 29, so that the insert 28, which is to be used next, is displaced in the radial direction. After this radial movement, in the course of the axial movement, the connecting element 34 engages in the receiving chamber 29 and in the insert 28. For this purpose, the connecting element 34 is constructed, in particular, as a piercing element, for example in the form of a cannula or needle, with a corresponding tip, which in particular contributes to the puncturing of the storage chamber 31 or to another penetration into it, so that the desired fluidic connection is established. Thus, the fluidic connection for the discharge medium to the storage chamber 31 is provided and the discharge medium can be supplied to the storage chamber 31, whereby the formulation 2 is ejected.

In the illustrated embodiment, the outer engaging portion 25, the finger 33 and the connecting member 34 form the connecting device 24 or components thereof. However, other structural solutions are also possible, so that the containers 4 can be opened or pierced one by one or, if necessary, on the supply side and / or the outlet side or connected to the dispensing device 5, or another

MerrecfcLvche ;; AT13748U1 2014-08-15 re fluidic connection, z. B. for the direct supply or the intake of ambient air, and in particular the corresponding insert 28 can be moved preferably in the radial, but possibly also in the axial direction, the respective openings 30 of the receiving chamber 29 can be opened and / or the storage chamber 31 in Insert 28 connected to the supply of discharge medium, in particular the connecting element 34 can be introduced into the storage chamber 31.

In the illustrated embodiment, in particular causes an axial movement opening, connecting or piercing by the connecting device 24, preferably at right angles to the discharge direction 11 or to the conveying direction of the containers 4 or the movement or rotation of the reservoir 3. In the illustrated embodiment, the connecting or piercing takes place in particular in the axial direction. In principle, however, also radial or other connection or piercing is possible, which can also be effected if necessary by means of the axial movement, which is provided by the gear 15 or carried out.

Theoretically, the direction of joining, opening, piercing and / or dispensing 11 may also be radial.

Particularly preferably, the connecting device 24 - in particular as well as the dispensing device 5 and / or the transport device 23 - actuated by opening and / or closing the cover 10 and / or operated by the preferably common gear 15 or at least one axial movement.

According to another feature, which is explained below with reference to another embodiment, it is also possible to arrange the transport device 23 and / or the connecting device 24 within the annular arrangement of the reservoir 3 or the containers 4. This in turn contributes to a particularly compact structure of the atomizer 1 and in particular to a minimization of the height of the atomizer 1 in the axial direction.

The reservoir 3 is preferably rigid. The term " rigid " should be understood that the reservoir 3 or its receiving chambers 29 preferably form a sufficiently stable or well-defined support and possibly guide for the inserts 28. However, other structural solutions are also possible. For example, can be achieved by external guidance of the reservoir 3 or the corresponding receiving chamber 29, the desired guidance of the insert 28 contained in the receiving chamber 29, even if the reservoir 3, for example, is not rigidly constructed. Alternatively or additionally, the insert 28 can also be completely removed from the reservoir 3 for connecting the container 4 or when opening the receiving chamber 29 or for dispensing the respective dose. In this case, the reservoir 3, for example, in particular also be designed only as a blister pack or other packaging.

FIG. 2 shows the atomizer 1 in the activated state. Ambient air is sucked into the pump chamber 6. The spring 14 is stretched. The selected for the delivery of the next dose container 4 has been opened and connected, the corresponding insert 28 has been moved radially outward and connected to the supply of the dispensing medium by means of the connecting element 34, in particular pierced by the latter.

In the illustrated embodiment, the actual delivery and in particular the atomization of contained in the pierced storage chamber 29 Formulation 2 or dose after appropriate triggering or further actuation, for example, after another or further actuation of the cover 10, carried out, but in particular in that the actuating element 21, which in this state has preferably only been moved outward in the axial direction, is actuated, in particular pressed inwardly in the axial direction by a user or patient (not shown). This releases the latch or other engaging means so that the spring accumulator or spring 14 can relax. The discharge medium in the pump chamber 6 is pressurized and 12/73

SförreÄcses AT 13 748 U1 2014-08-15 passed through the discharge channel 35 and the connecting element 34 in the adjacent storage chamber 31. The discharge medium continues to flow through the channel 32 and out of the insert 28, at the same time expelling the formulation 2 contained in the storage chamber 31. The aerosol or spray cloud thus obtained is expelled through the optional grid 9 via the mouthpiece 8 so that the user or patient can inhale the expelled and, in particular, atomized formulation 2.

Fig. 5 shows the nebulizer 1 in a schematic sectional view after inhalation, d. H. with a relaxed spring 14, empty container 4 and the cover 10 still open.

After inhalation or after delivery of the formulation 2, the cover 10 is closed again. This is done in particular in the opposite direction of rotation. Due to the coupling provided - in particular by means of the gear 15 - the inner engagement member 19 is moved in the axial direction back to its initial position shown in Fig. 1, wherein the spring memory or the spring 14 again stretched and finally the operative connection or another axial connection between the engagement member 19 and the dispenser 5 or the spring accumulator - in particular via the locking arm 20 - is restored, so that the starting position shown in Fig. 1 with relaxed spring 14 and with the desired holding connection between the engaging member 19 and in particular the bellows 7 and / or the spring 14 is restored. In addition, the reservoir 3 is again moved back to its axial starting position, d. H. pushed back in the axial direction in the opposite direction. As a result, in particular, the reservoir 3 is released from the finger 33 and from the connecting element 34.

The advancement or further rotation of the reservoir 3 to a container preferably superimposed on the axial movement and this always takes place during the up and / or down movement, d. H. when opening and / or closing the cover 10, when the connecting device 24 - in particular the fingers 33 and connecting element 34 - no longer engages in the reservoir 3, but allows the desired rotational movement. In the illustrated embodiment, therefore, the sliding guide or the control cam 26 is preferably designed such that the desired advancement or further rotation of the reservoir 3 to a container 4 always takes place only during a part of the axial movement.

The measures described above lead to a very compact, simple structure of the atomizer 1, in particular with few components.

The proposed atomizer 1 can be operated very simply and intuitively. Essentially, only the opening and closing of the cover 10 is required for its operation. All intended functions or processes are thereby triggered or controlled or run off automatically. If the atomizer 1 is constructed as an active atomizer 1, in addition to the actuation of the cover 10, it is only necessary to trigger the actual delivery and atomization after opening the cover 10. This is preferably done by pressing, in particular pressing, the actuating element 21. Since the actuating element 21 is preferably actuatable, moves outward in the axial direction and / or accessible only when the atomizer 1 is activated, d. H. After the cover 10 has been opened, a simple intuitive operation is possible and wrong operation excluded.

In particular, the actuating element 21 passes through an opening in the cover 10. Again, however, other embodiments are possible. It is also possible that the actuating element 21 in the activated state of the atomizer 1 accessible, z. B. is not obscured by the cover 10 is.

After inhalation, the atomizer 1 or the cover 10 can be closed again. The cover 10 is preferably secured against closure, as long as the actuator 21 has not been actuated, d. H. in the illustrated embodiment, is still in the axially outward disengaged position, or until the formulation 2 has been removed from the already opened or bonded or pierced container 4

& te ^ id »scHg ρίίκηΕδίϊϊί ΑΤ 13 748 U1 2014-08-15 been used.

Fig. 3 shows the proposed atomizer 1 in the open or activated state. The cover 10 has thus been rotated by about 160 ° to 180 ° with respect to the closed transport position shown in Fig. 1. The cover 10 may be rotated for opening and closing, preferably only in opposite directions. Therefore, it is preferable to provide a rotation stopper 36 which is externally visible in the illustrated embodiment and protrudes from the periphery or housing 13, for example. This helps to ensure a simple and intuitive operation of the nebulizer 1 because the user intuitively detects how far and in which direction the cover 10 has to be opened or closed. Particularly preferably, the atomizer 1 is designed such that the rotation stop 36 forms a stop for the cover 10 in both the open and in the closed state. Alternatively, separate projections or stops may be provided for this purpose.

The atomizer 1 or the cover 10 also preferably also has a locking device 37, which is shown in Fig. 4c (partial section through the atomizer 1 in the activated state) and ensures that the cover 10 are alternately always opened and closed can. For this purpose, for example, at least one corresponding latch 38 or the like is provided, for example, between areas of the cover 10 and the housing 13, which are arranged in the axial direction above or behind one another, which provides the desired functionality.

Preferably, the nebulizer 1 or the locking device 37 comprises a control ring 39, which is shown separately in the perspective view in Fig. 4d. The control ring 39 is provided on its two axial or flat sides with a toothing or a latch 38. The control ring 39 is in particular in an annular channel or the like in the atomizer 1 or in the housing 37 rotatably leads, as shown in Figs. 1, 2 and 4c.

In a latch 38 of the control ring 39 engages a locking arm 40a on the housing side, while in the other latch 38 engages a locking arm 40b on the cover side, see Fig. 4c. The latches 38 and the locking arms 40a and 40b are matched to one another such that the cover 10 can initially be moved or rotated in one direction with respect to the housing 13 and thus rotation in the opposite direction by the locking device 37 or the locking arms 40a or 40b acting in the opposite direction is prevented.

Preferably, a number of locking arms 40a are provided on the housing 13, which engage in the associated latch 38 of the control ring 39 and allow rotation of the control ring 39 only in one direction with respect to the atomizer 1 or the housing 13. As a result, a number of locking arms 40b are also preferably arranged on or in connection with the cover 10 and allow rotation of the control ring 39 only in one direction of rotation with respect to the cover 10.

In order to ensure that the cover 10 can always be opened or closed alternately, the rotation of the control ring 39 relative to the housing 13 or the cover 10, which in each case is possible only in one direction, can be alternately blocked and only reactivate or unlock when the respective end position is reached, d. H. either in the fully open or the fully closed position. This blocking of the control ring 39 relative to the housing 13 or the cover 10 will be briefly explained here below with reference to another section through the atomizer 1 according to FIG. 4e.

On the control ring 39 stops 40c are formed, as shown in Fig. 4d, which cooperate with stop arms 40d, see Fig. 4e. Fig. 4e shows an example of the blocking of the control ring 39 against rotation relative to the housing 13. This blocking takes place in a corresponding or similar manner between the cover 10 and the control ring 39 14/73

AT13 748U1 2014-08-15 and it acts during the opposite movement of the cover 10 with respect to the housing 13.

In the above-mentioned blocking, at least one stop 40c abuts on at least one stop arm 40d, so that the rotation of the control ring 39 relative to the housing 13, which would otherwise be possible in the direction of rotation, by the locking arm 40a and its associated latch 38th is not locked, is also locked. This blocking by the stop arm 40d is maintained until the cover 10 moves to its final position.

If the end position is reached, formed on the cover 10 control slope or sliding surface 40e leads to springs of the stop arm 40d, so that now the previously blocked stop 40c is released and thus the cover 10 is rotated back relative to the control ring 39 and thus again can be rotated or moved in the opposite direction. At the same time comes in this end position another, not shown in Fig. 4e stop 40 c of the control ring 39 for abutment with a stop arm 40 d, which is arranged on the cover 10, whereby the relative rotation of the control ring 39 is blocked with respect to the cover 10. As a result, the cover 10 can now be rotated or moved in the opposite direction only together with the control ring 39 until the other end position is reached. In the other end position, in turn, the rotation of the control ring 39 is blocked relative to the housing 13 and the rotation of the cover 10 is in turn released relative to the control ring 39. Consequently, the cover 10 can be opened or closed only alternately completely, so that a simple and intuitive operation or operation ensured and in particular a wrong operation is excluded.

The illustrated embodiment illustrates an active nebulizer 1. Theoretically, however, nebulizer 1 may also be constructed as a passive nebulizer. In this case, the dispensing device 5 and / or the energy store or the spring store can or can be dispensed with. Instead, for example, ambient air may be aspirated by inhalation during inhalation, and this air is passed through the corresponding container 4 -in particular the storage chamber 29 and the channel openings 30 of the respective insert 28 -through the mouthpiece 8, so that the formulation 2 to the desired Way is discharged or ejected and atomized.

If necessary, the spring accumulator can also be used independently of the dispensing device 5, for example for the advancement and / or opening or closing of the containers 4, in particular for driving and / or operating the transport device 23 and / or the conveying device 24.

If the atomizer 1 has no dispensing device 5 and / or no energy store, the actuating element 21 and an actuating device which is required in addition to the movement of the cover 10 - d. H. an additional triggering of the actual release and atomization of the formulation 2 - omitted. Rather, it is then rather sufficient to open the cover 10 in order to activate the atomizer 1, so that the next container 4 is ready for inhalation directly with its dose or formulation 2 and the inhalation can take place immediately.

The mouthpiece 8 is preferably of fixed construction and / or radially aligned and / or preferably formed directly on the housing 13. This leads to a simple and compact structure of the atomizer 1, in particular with an at least substantially smooth outer contour. However, the mouthpiece 8 can theoretically also be movable, for. B. foldable, sliding, telescopically extendable or movable in any other way be. Alternatively or additionally, the mouthpiece 8 for the delivery of the formulation 2 or the aerosol in another direction, for. B. diagonally or axially aligned or arranged.

The proposed atomizer 1 preferably additionally has a counting device (not shown). 15/73 isiCTeldiiscists föfeütäffli AT13 748U1 2014-08-15 [00143] The proposed atomizer 1 preferably operates purely mechanically.

The proposed atomizer 1 is preferably constructed at least substantially only of plastic components or parts or at least substantially only made of plastic. Only the spring 14 and optionally the grid 13 can be made if necessary from metal.

According to a further feature, the manual operation of the active dispensing and atomization of the formulation 2, which are carried out in the first embodiment by pressing the actuating element 21, in particular also be dispensed with. Instead, preferably, a breathing-controlled actuation is provided. For example, if a corresponding vacuum is created in the nebulizer 1 by inhalation, the retaining connection between the inner engaging member 19 on the one hand and the biased spring 14 or the bellows 7, another conveying or pumping element or the like can be solved so that the desired Delivery and in particular the atomization of the formulation 2 in the inhalation virtually automatically, namely using the stored energy in the energy storage or spring energy can be done.

In the following, some further embodiments of the proposed nebulizer 1 will be explained, emphasizing only the essential differences or new aspects in comparison with the first embodiment. The above explanations and remarks therefore still apply as above or in addition thereto.

Fig. 6 and 7 show schematic views of a second embodiment of the proposed atomizer 1. Fig. 6 shows the atomizer 1 in the closed position with not yet pierced container 4. Fig. 7 shows the atomizer 1 in the activated state with open or pierced container 4.

In the second embodiment, the reservoir 3 is not movable in the axial direction, in contrast to the first embodiment. Instead, the connecting device 24 is preferably slidable or movable in the axial direction. In the illustrated embodiment, the reservoir 3 is held by a rotatable inner part 41. The connecting device 24 (at least its connecting element 34 and preferably its fingers 33) is fixed to a support 42 which is movable in the axial direction, but not rotatable. The carrier 42 is in turn in the axial direction preferably by opening and / or closing the cover 10, in particular by means of the gear 15, which is not shown here in detail, movable.

The carrier 42 preferably has an axially acting toothing 43, for example with sawtooth-like sliding surfaces or the like, which cooperates with and in particular engages with complementary or corresponding counter toothing 44 which is provided or formed on the inner part 41 that the axial movement of the carrier 42 causes a defined, stepwise further rotation of the inner part 41 with the reservoir 3.

In a second embodiment, the support 42 fits over or around the inner part with the reservoir 3, preferably around the circumference and in particular such that the support 42 extends from an end face of the inner part 41 around the exterior of the reservoir 43 to the reservoir the other end surface of the reservoir 3 and radially inwardly back to an inner edge on which a preferably axial toothing 43 is formed. The carrier 42 has a peripheral opening 45 which, at least in the activated state, lies on an extension of the particular opened or pierced container 4 or the radially advanced insert 28, so that the dispensing of the formulation 2 is possible and not hindered.

In the second embodiment, the same operation is used as in the first embodiment.

Fig. 8 shows a schematic sectional view of a third embodiment of the proposed atomizer 1 in the open, activated state. The third embodiment largely corresponds to the second embodiment, but wherein the connecting device 24 is not the same as in the second embodiment of the flat side of the annular flange of the 16/73

Ssterreidiiscists pitwtot AT 13 748 U1 2014-08-15

Inner part 41 is covered, but from the opposite flat side - in particular with the finger 33 and the connecting element 34 - engages in the reservoir 3.

Fig. 9 shows a schematic view of a fourth embodiment of the proposed atomizer 1 in the transport position or in the locked state.

The cover 10 is designed here in the form of a cap. The pivot axis of the cover 10 is arranged or shaped eccentrically, in particular in the region of the circumference or edge of the atomizer 1. In contrast to the previous embodiments, the cover 10 essentially covers only the mouthpiece 8.

In the fourth embodiment, the opening and / or closing of the cover 10 is preferably not coupled with the other functions of the nebulizer 1.

The atomizer 1 has a release mechanism 46, which is constructed in particular as circumferentially movable slide.

Fig. 10 shows a schematic section of the atomizer 1 in the unlocked state.

In the fourth embodiment, the atomizer 1 has two preferably outer housing parts, in particular an upper housing part 47 and a lower housing part 48, which can be moved towards each other in the axial direction. In particular, the housing parts 47, 48 are preferably biased away from each other by a plurality of spring elements 49, so that in the unlocked and uncompressed state of the upper housing part 47 is raised in relation to the lower housing part 48 in the axial direction, as shown in Fig. 10.

The two housing parts 47, 48 can be moved against each other against the force of the spring elements 49 in the axial direction. In the axially compressed state, the two housing parts 47, 48 in particular lock together. This lock can be released by operating the release mechanism 46.

Starting from the transport position, the upper housing part 47 is automatically moved away from the lower housing part 48 in the axial direction after the release of the upper housing part 47 by the spring elements 49. This displacement or lifting movement causes the actuation of the dispensing device 5, namely the enlargement of the pump chamber 6 and the suction of ambient air. Furthermore, the spring 14, which is associated with the dispensing device 5, in particular to the bellows 7, thereby tensioned or compressed in the axial direction. The spring elements 21 consequently have a greater spring force than the spring 14.

In addition, the aforementioned axial or stroke movement causes the actuator 41 associated with the spring 14 to be raised in the axial direction or moved outward.

The axial lifting movement further causes the reservoir 3 to be moved in the axial direction and disconnected from the connecting device 24 (not shown in detail).

Next, the two housing parts 47, 48 in the axial direction against the force of the spring elements 49 by a user (not shown) must be compressed manually. During this axial movement and / or during the previous stroke movement, the reservoir 3 is rotated further around a container 4. The further rotation or advancement of the reservoir 3 is preferably again carried out by sliding or sliding control of the transport device 23 or the like. In the further course of the container 4, which has been rotated to the dispensing position, then opened and, preferably in turn via the connecting device 24 (not shown here), connected to the conveying device.

Fig. 11 shows the activated state of the atomizer 1, which results after compression, with the interlocked or locked housing parts 47, 48 and with the axially protruding actuator 21. Preferably, the actuator 21 can only after reaching this state or only after opening 17/73

AT 13 748 U1 2014-08-15 of the cover 10 are actuated, so that the release and the atomization of the formulation of the dose from the opened container 4 is made possible.

By pressing - in particular by axial impressions - of the actuating element 21, the blocking of the spring 14 is released, so that the spring 14 relax in the axial direction and thereby actuate the dispensing device 5, in particular put the air contained in the pump chamber 6 under pressure can, so that this air is conveyed through the connected container 4 through and delivers the formulation 2 in the desired manner through the mouthpiece 8.

Also, the fourth embodiment allows a very simple, intuitive operation. A wrong operation is excluded in particular by suitable blocking devices.

Figs. 12 to 14 show a fifth embodiment of the proposed atomizer 1 in various states corresponding to those shown in Figs. 9 to 11.

The fifth embodiment differs from the fourth embodiment essentially in that the direction of opening, piercing and / or sliding and / or the orientation of the containers 4 or the inserts 28 at least substantially axially or parallel, but not radially in Relative to the axis 12 or the annular arrangement of the reservoir 3 or the container 4 runs / run. In the illustrated embodiment, the mouthpiece 8 is thus arranged or formed above the reservoir 3 on the side of the atomizer 1 or housing 13 - in this case, in particular the lower housing part 47 - with the mouthpiece 8 substantially at right angles or perpendicularly from the flat side of the atomizer 1 protrudes or protrudes.

In the fifth embodiment, starting from the transport position shown in Fig. 12, first of all, the cover 10 must be opened, and this is preferably in the illustrated embodiment about the tangential axis 12 pivotally. Only after opening the cover 10, the release mechanism 46 is accessible. Otherwise, the same operation as in the fourth embodiment.

Fig. 15 shows in a schematic section a sixth embodiment of the proposed atomizer 1 in the transport position. The sixth embodiment is in principle similar in particular to the fourth embodiment. However, in contrast to the previous embodiments, the sixth embodiment has no dispensing device 5. It is rather a passive atomizer 1.

In the transport position, the two housing parts 47 and 48, which can be moved away from each other in the axial direction, in particular by at least one snap hook 50 or the like locked or locked. The at least one snap hook 50 can preferably engage behind an annular shoulder 51 or the like on the other housing part 47, 48, so that in the locked position, an interlocking holding connection between the two housing parts 47, 48 is made in the axial direction.

In the fourth embodiment, a number of spring members 49 are preferably provided. In the sixth embodiment, preferably only a central spring element 49 is provided, which is formed in particular by a central coil spring which spreads the two housing parts 47 and 48 away from each other. If the central release mechanism 46, in this case actuated, in particular by pressing in the axial direction, the at least one snap hook 50 or the like is rebounded, i. H. the locking of the two housing parts 47 and 48 is released, so that the two housing parts 47 and 48 can move away from each other in the axial direction, as shown in Fig. 16. As a result of this lifting movement, the reservoir 3 is preferably further rotated by a container 4. The movement away or axial movement takes place automatically due to the spring force of the spring element 49. This axial movement is preferably in turn converted by a gear or a toothing, a sliding guide or the like (not shown) in the desired, stepwise rotational movement of the reservoir 3. Preferably, the aforementioned 18/73

AT13 748U1 2014-08-15

Ballpoint pen mechanism also used here. At the same time, as a result of the movement away, the connecting element 34 of the connecting device 24 can be lifted off the container 4, which has already been emptied during the last delivery.

Then, the two housing parts 47, 48 are compressed manually against the force of the spring element 49. In this way, the spring element 49 is again tensioned and the next container 4 is connected or opened by the connecting device 24, in particular its connecting element 34. Finally, the at least one snap hook 50 automatically locks the two housing parts 47 and 48 together again in the compressed end position, as shown in FIG.

Now the inhalation can take place. In the sixth embodiment, by inhalation, a user or patient (not shown) creates a stream of air which passes through an inlet 52 of the connector 34 into the opened or pierced container 4 and through an outlet 53 of the connector 34 together with the formulation 2 from the container 4 is directed to the mouthpiece 8, as is schematically indicated in Fig. 17 for the connecting element 34 by arrows 54.

In the sixth embodiment, the respective container 4 is preferably also opened or pierced in the axial direction. For example, the reservoir 3 is here formed as a blister ring (not shown) comprising a plurality of blister pockets, or in particular as an annular support 55 having a plurality of preferably axially open recesses 56 for receiving the blister ring (not shown) or blister pockets , as indicated in particular in the detail shown in Fig. 18. In the illustrated embodiment, the reservoir 3 is in particular formed directly from the lower housing part 48 or in particular is firmly bonded thereto.

The sixth embodiment preferably comprises a blocking device 57 which blocks further actuation, in particular further opening of the atomizer 1 or movement of the housing parts 47 and 48, after all the containers 4 have been used or emptied. The blocking device 57 is shaped, for example, like a hook on the reservoir 3, an associated inner part 41 or on the annular support 55 and engages, for example, when the blocking position is reached, in an abutment 58 formed on the upper housing part 47 is, so that the two housing parts 47 and 48 can not be moved away from each other in the axial direction. This blocking is preferably also irreversible. Fig. 18 shows the housing parts in the still retracted position.

Like the others, the sixth embodiment preferably also comprises a counting device 59, which in the illustrated embodiment preferably has a corresponding scale 60 on the reservoir 3, in particular on the outer circumference of the reservoir 3 or on the lower housing part 48, and a corresponding window 61 in the housing 13, in particular on the upper housing part 47, comprises. The relative rotational position of the reservoir 3 corresponds to the number of containers 4 that have already been used or are still available for use. Thus, the scale 60 may indicate the number of containers 4 that are still available for use or that have already been used. Fig. 19 shows the counting device 59 in a cutaway side view.

Fig. 20 shows in a view corresponding to Fig. 19, the atomizer 1 in the unlocked state, d. H. with the axially raised upper housing part 47. In this position, the reservoir 3 is preferably displaced in the axial direction relative to the window 61, so that the scale 60 is not visible. Instead, a symbol, in particular an arrow or the like, is displayed, which shows the user the operation, namely by the required compression of the two housing parts 47 and 48. In that regard, the counter 59 is not only counting, but has another function and contributes to the operation of the proposed atomizer 1 at.

The atomizer 1 according to the sixth embodiment may have a central or axial 19/73

AT13 748U1 2014-08-15

Recess 62 in the housing 13 or in the upper housing part 47 have, as indicated in Fig. 15 and 16. This recess 62 may be used for additional functions or devices.

Fig. 21 shows an alternative embodiment of the nebulizer 1 with a timer 63 or with a timing device. The timer 63 is preferably incorporated in the recess or otherwise integrated into the atomizer 1 or its housing 13. In particular, the clock generator 63 is constructed in such a way that a preferably optical, acoustic and / or vibrating signal can be output in order to remind the user of the use of the atomizer 1.

Fig. 22 shows another alternative embodiment of the nebulizer 1 with a sealable chamber or other container for pharmaceuticals or the like (not shown). In particular, the recess 62 is constructed to receive medicines or the like, and may be closed by, for example, a lid 64 or other closure.

Fig. 23 is a schematic sectional view showing an eighth embodiment of the proposed atomizer 1 in the transport position, namely with the cover 10 closed. In the eighth embodiment, as in the seventh embodiment, it is a passive atomizer 1. Opening and closing and actuation of the atomizer 1 by turning or pivoting the cover 10, however, corresponds in principle to the first to third embodiments.

In the eighth embodiment, the reservoir 3 and the connecting device 24 are constructed substantially as in the seventh embodiment. The connecting device 24 or its connecting element 34 can be moved by opening and closing the cover 10 by means of the transmission (not shown in detail) in the axial direction. In the transport position, the connecting device 24 or its connecting element 34 is moved away from the reservoir 3 in the axial direction.

By opening the cover 10 (pivoting about preferably up to about 180 °), the reservoir 3 is first advanced or further rotated and at the duration of the axial movement, the next container 4 is opened by means of the connecting device 24, in particular pierced by the connecting element 34 or otherwise connected. Fig. 24 shows this activated state in a schematic sectional view.

When a user or patient (not shown) inhales to inhale, an air flow is generated, which is passed through the connector 34 through the container 4 or the storage chamber 31, such as a blister bag or the like, and in this way the formulation 2 contained in the container 4 ejected and discharged through the adjacent mouthpiece 8.

For a simple and inexpensive construction is possible, the inlet 52 and the outlet 53 are preferably formed by a common component, in particular the one-piece connecting element 34. Furthermore, the connecting element 34 preferably also has an outlet channel 65, which is adjacent to the outlet 53 and, in particular, widens in a funnel shape or in another suitable manner. Thus, a mouthpiece 8 in the conventional sense or an extension piece or the like, as it is often used in inhalers, not needed. Rather, it is sufficient that a housing opening and, if necessary, a corresponding design of the housing 13 are provided so that a compact, space-saving mouthpiece 8 for a user or patient (not shown) is produced.

Fig. 25 is a schematic view illustrating the transporting device 23 of the nebulizer 1 according to the eighth embodiment. In particular, an axial toothing 43 on the reservoir side and an axially movable counter toothing 44 on the housing side - in particular together with the connecting device 24 - cooperate in such a way that the desired incremental advancement or further rotation of the reservoir becomes possible 748 U1 2014-08-15 voirs 3 at each axial movement of the counter teeth 44 relative to the teeth 43 in connection with the opening of the cover 10 is achieved. In particular, here again the aforementioned ballpoint pen principle is used.

However, other structural solutions are possible to the desired gradual advancement or further rotation of the reservoir 3 from the movement of the cover 10, which is associated with the opening and / or closing, in particular the pivoting movement and / or a resulting axial movement , to reach.

In contrast to the seventh embodiment, in the eighth embodiment, the counting device 59 is preferably arranged on the flat side or the axial side of the atomizer 1, wherein in particular the window 61 is formed in the cover 10 and in the housing 13, so that the current Stand of the counter can be read preferably always, even if the cover 10 is closed.

Also in the eighth embodiment, the reservoir 3 is again preferably provided with an annular support 55 for holding a blister assembly, in particular a blister or the like, but here virtually any type of reservoir 3 - especially even a reservoir 3 with inserts 28, which form the containers 4, are used.

The eighth embodiment allows a particularly simple operation, because only the opening of the cover 10 is required to activate the atomizer 1, d. H. ready for atomization or inhalation. Even after atomization or inhalation, no additional operations are required. It is necessary to close only the atomizer 1 or the cover 10. If the cover 10 is closed, the connecting device 24 or its connecting element 34 in the axial direction of the reservoir 3 or the container 4, which was last opened, moves away, so that again the transport position shown in Fig. 23 is taken.

Fig. 26 shows a very schematic, partial representation of the concept of a ninth embodiment of the proposed nebulizer 1. The ninth embodiment relates to an active nebulizer 1 with a dispenser 5 and an energy or spring storage, preferably within the annular arrangement of the reservoir 3 or the containers 4 are arranged, which is indicated in Fig. 26 only by receiving chambers 29.

In the ninth embodiment, the dispensing device 5 is again preferably designed as a pump and in particular equipped with the bellows 7, which is for the pumping preferably in a radial direction movable, in particular extendable and collapsible or compressible, is. The spring accumulator or the spring 14 is preferably arranged in this pumping direction behind the bellows 7, in particular on the side facing away from the connecting device 24 side.

Fig. 26 shows the spring accumulator or the spring 14 in the prestressed state with the drawn-out bellows 7. In this state, the dispenser 5 or the bellows 7 has already sucked in ambient air.

The dispenser 5 with the spring accumulator is preferably movable like a carriage. To open the container 4, which is to be used next, the dispensing device 5 is first advanced radially with the connecting device 24 or the connecting element 34, so that the next container 4 or the next insert 28 is radially pierced or connected to the dispenser 5 and radially is moved away. This state is shown in the schematic illustration in FIG. 27. Then the operation takes place. By relaxing the spring 14 in the radial direction, the bellows 7 is compressed and the air contained therein flows through the connecting element 34 and the connected container 4 - in particular the connected insert 28 -, whereby the formulation contained in the container 4 or the insert 28 2 is ejected. Thereafter, the dispensing device 5 can be radially retracted with the connecting device 24 21/73

AT13 748U1 2014-08-15 the. In addition, the spring 14 is again biased and secured or locked in the biased position.

With the opposite radial movement, the next container 4 or the next insert 28 can be pierced and in particular pushed radially outward to open its respective seal. During this radial movement, the spring 24 remains compressed or stretched and the bellows 7 expanded. Thus, the activated state of the atomizer 1 is achieved.

With the actuation of the actuating element (not shown), the spring 14 is preferably relaxed, so that the bellows 7 is compressed, d. H. the pump is actuated so that the compressed dispensing medium, i. H. Air is forced through the insert 28 and dispenses the appropriate dose of the formulation 2 or expelled or atomized or desag-glomerated and produces the desired spray of Formulation 2.

Part of the radial movement is also preferably used to clock or move the reservoir 3 to the next container 4, d. H. to operate the transport device 23.

In the ninth embodiment, the transport device 23 preferably engages inwardly on the reservoir 3, in particular via a pinion 66, which preferably engages in an internal toothing 67 of the reservoir 3.

It should be noted that the connecting device 24 and the pump 5 preferably form a unit or are interconnected.

The connecting element 34 is connected to the carriage and / or the pump 5 and / or the bellows 7.

In the ninth embodiment, the containers 4 / receiving chambers 29 preferably form separate parts which are mounted on the preferably annular support 55, in particular in a form-fitting and / or rigid manner. The receiving chambers 29 or the containers 4 are preferably separate or individually closed by appropriate seals and / or preferably at least on its outer periphery (not shown in Figs. 26 and 27).

Fig. 28 shows a tenth embodiment of the proposed atomizer 1 in a very very schematic, batchwise manner. The tenth embodiment is related to the ninth embodiment, this is particularly similar, particularly preferred with regard to the arrangement and / or function of Dispensing device 5 and the connecting device 24 so that they no longer need to be explained.

29 shows the atomizer 1 according to the tenth embodiment in a schematic sectional view, in contrast to FIG. 28 with the housing 13 and the preferably rotatable or pivotable cover 10.

In the tenth embodiment, a pivotal or rotational movement, in particular of the cover 10, can be converted into a linear and / or radial movement for actuating the dispensing device 5 and / or the connecting device 24, most preferably for moving the connecting element 34. In particular, a sliding and / or automatic coupling or control is obtained.

In the illustrated embodiment, the atomizer 1 has at least one control element 68, which is designed in particular in the form of a disk (cf., FIG. 28). The control member 68 is preferably rotatably coupled to the cover 10 (in the illustrated embodiment via an axial engagement 69, as indicated in FIG. 29) or is formed, for example, by the cover member 10.

Particularly preferably, the control element 68 forms a sliding guide or a series of sliding guides, so that in particular both the dispensing device 5 and the connecting device 24 or its connecting element 34 can reach the desired or required 22/73 asterreidBsd! "Pitwiarot AT 13 748 U1 2014- 08-15

Be operated manner. However, it is theoretically also possible to use separate controls 68, sliding guides and / or other gear connections for controlling and actuating the dispensing device 5 on the one hand and the connecting device 24 or its connecting element 34 on the other hand and / or for different sections of the movements.

In the illustrated embodiment, a first control cam or slide 70 is provided for preferably linear or radial movement of the connector 24 or slide 79 formed by the dispenser 5 and / or the connector 24. For this purpose, in particular a first engagement element 71 engages in the first sliding guide 70. The first engaging element 71 is preferably rigidly connected to the connecting device 24 or its connecting element 34 directly or indirectly.

The first sliding guide 70 is shown in FIG. 28 as an opening. However, this may in particular also be a recess or a groove or the like, as shown in FIG. 29.

The path of the first sliding guide 70 determines the transmission clutch or the dependency ratio of the linear movement, which can also extend in the circumferential direction and / or radially, of the rotational movement. In the illustrated embodiment, the first sliding guide 70 comprises a first portion 72 which extends in particular over a circumference, a subsequent second, preferably linear and / or a radial component-containing portion 73 and / or a third portion 74, in particular over again a circumference runs.

Thus, during operation, that is, there is. H. pivoting, the cover 10 from the position shown in Figs. 28 and 29 (closed position or transport position) first in the course of the first portion 72, no linear or radial movement of the connecting device 24 or the carriage 79. Only further along the second portion 73rd There is a linear or radial movement, in the illustrated embodiment of the carriage 79 or the connecting device 24, so that the connecting element 34 comes into contact with the next container 4, in particular in the next container 4 or the next insert 28 engages, most preferably one makes fluid connection between the dispenser 5 or the connecting element 34 and the storage chamber 31 and optionally moves the insert 28 through the opening 30, in particular by advancing it radially, so that the opening 30 is opened. The atomizer 1 assumes the activated position.

During the transition from the closed state to the activated state, the dispensing device 5 or the spring accumulator or the spring 14 was preferably already tensioned. Therefore, the actuating element 21 can now be actuated so that the formulation 2 is discharged, in particular by a locking arm 20 is deflected and thereby the spring 14 or the bellows 7 relaxes and the pump chamber 6 is compressed, whereby the formulation 2 by the release medium in the desired Way, as explained above, ejected or discharged and in particular atomized.

In the illustrated embodiment, the cover 10 or the control element 68 preferably simultaneously serves to actuate the dispensing device 5, in particular for biasing the spring accumulator or the spring 14. The control element 68 comprises for this purpose a second control cam or sliding guide 75, with the particular a second engaging member 76 cooperates, in the illustrated embodiment, with the dispensing device 5 or the spring accumulator or the spring 14, in particular a radially or linearly displaceable abutment 77 of the spring 14, in conjunction or, directly or indirectly, is firmly connected thereto.

Particularly preferably, the abutment 77 is slidably or slidably guided on the dispenser 5 or on the carriage 79, which in turn in the direction of movement - in this case the radial direction - slidably slide and in particular the connecting device 24 or its connecting element 34 holds or wearing. 23/73

Fig. 29 shows the spring 14 in the cocked position (in the compressed state in this case). The abutment 77 is held at least by means of the locking arm 20 in the tensioned state. The second slide guide 75 is preferably formed in the illustrated embodiment such that in the closed or transport position the spring accumulator or spring 14 is secured against inadvertent release, particularly by a shoulder 78 which causes radial movement of the second engagement member 76 in that position blocked.

When the actuator 21 is actuated, the lock arm 20 is deflected or the lock engagement is released and the spring accumulator or the spring 14 is relaxed or the dispenser 5 is triggered. The spring 14 then compresses the bellows 7 or the pumping chamber 6 in the manner described above, in the illustrated embodiment linearly or in the radial direction. The formulation 2 (not shown in FIGS. 28 and 29) is then dispensed from the connected container 4 or the connected insert 28 and in particular atomized, as already explained with reference to the other embodiments.

During relaxation, the second engagement element 76 moves in particular in the direction of the center of the atomizer 1 or the control element 68 or to the axis of rotation of the cover 10 and optionally beyond. The second sliding guide 75 is correspondingly cut free, so that this movement is possible. In the illustrated embodiment, this movement is substantially along a radial portion 80 of the second sliding guide 75.

In the illustrated embodiment, in particular, while the cover 10 is closed or moved back, the control 68 is rotated back or the spring memory or the spring 14 tensioned again.

While the control 68 is moved back or rotated from the position in the activated state (with respect to which in Figs. 28 and 29, preferably rotated by 90 ° to 180 °), the abutment 77 via the second engaging element 76 via a certain Section of the opposite radial movement of the carriage 79 or the first engaging member 71 retained by a retaining portion 81 of the second slide 75 so that in this portion of the movement of the spring accumulator or the spring 14 again stretched and the bellows 7 is pulled apart again, in particular until a lock takes place by means of the locking arm 20. During this movement, the connecting element 34 is preferably at least partially retracted from the connected container 4 or the connected insert 28 at the same time.

In the course of the further linear or radial movement, the dispensing device 5, the connecting device 24, the connecting element 34 and the carriage 79 are moved back together with the tensioned spring 14 to the initial position, which is shown in Figs. 28 and 29.

The movement described above takes place in the illustrated embodiment, in particular by closing the cover 10 and a concomitant turning back of the control 68th

FIG. 29 again shows the preferably annular reservoir 3 in a very schematic form. In this context, reference is made in particular to the remarks relating to the other embodiments.

During the opening movement and / or the closing movement of the cover 10 or the rotation of the control element 68, the transport device 23, not shown in the tenth embodiment, can preferably be actuated so that the reservoir 3 is advanced to the next container 4. This is done in particular by means of a corresponding or suitable transmission clutch or the like. For example, for this purpose, a displacement of the reservoir 3 in the axial direction can take place, as explained hereinbefore, wherein the advancement in the circumferential direction or in particular by means of a 24/73, isteTOdiiscises' föfeiitäWt AT13 748U1 2014-08-15

Control cam 26 or the like preferably takes place on the housing side. In particular or alternatively, as in the other embodiments, a gear coupling, in particular by means of a thread, can be used.

Individual features and aspects of the individual embodiments may also be combined as desired or used in other designs of nebulizers, inhalers, dispensers, or the like.

In the present invention, the term " atomizer " preferably be interpreted in a very broad sense to include other dispensers, dispensers or the like wherein the formulation 2 or other medium or fluid is atomized only when necessary and may optionally be dispensed in a different form.

Some preferred ingredients and / or compositions of preferably medicinal formulation 2 are listed below. As already mentioned, these are in particular powders or liquids in the broadest sense. More preferably, formulation 2 contains the following: The compounds listed below may be used in the device of the invention alone or in combination. In the compounds listed below, W is a pharmacologically active agent and is selected (for example) from the group consisting of betamimetics, anticholinergics, corticosteroids, PDE4 inhibitors, LTD4 antagonists, EGFR inhibitors, dopamine agonists, H1 antihistamines, PAF - There are antagonists and PI3-kinase inhibitors. Furthermore, double or triple combinations of W can be combined with each other and used in the device according to the invention. Combinations of W may be, for example, the following: [00228] - W represents a betamimetic combined with an anticholinergic, corticosteroid, PDE4 inhibitor, EGFR inhibitor or LTD4 antagonist, [00229] - W represents an anticholinergic agent combined with a betamimetic, corticosteroid, PDE4 inhibitor, EGFR inhibitors or LTD4 antagonists, [00230] - W stands for a corticosteroid combined with a PDE4 inhibitor, EGFR inhibitor or LTD4 antagonist, [00231] -W represents a PDE4 inhibitor combined with an EGFR inhibitor or LTD4-

Antagonists, [00232] -W stands for an EGFR inhibitor combined with a LTD4 antagonist.

The compounds used as betamimetics are preferably selected from the following compounds: albuterol, arformoterol, bambuterol, bitol-terol, broxaterol, carbuterol, clenbuterol, fenoterol, formoterol, hexoprenaline, i-buterol, isoetharine, isoprenaline, levosalbutamol, mabuterol, Meluadrin, Metaprote-renol, Orciprenalin, Pirbuterol, Procaterol, Reproterol, Rimiterol, Ritodrine, Sal-mefamol, Salmeterol, Soterenol, Sulfonterol, Terbutaline, Tiaramid, Tolubuterol, Zin-terol, CHF-1035, HO-KU-81, KUL- 1248 and [00234] 3- (4- {6- [2-hydroxy-2- (4-hydroxy-3-hydroxymethylphenyl) -ethylamino] -hexyloxy} -butyl-1-benzylsulfonamide [00235] - 5- [2- (2- 5,6-diethylindan-2-ylamino) -1-hydroxyethyl] -8-hydroxy-1H-quinolin-2-one [00236] - 4-hydroxy-7- [2 - {[2 - {[3- (3-one] 2-phenylethoxy) propyl] sulfonyl} ethyl] amino} ethyl] -2 (3H) -benzothiazolone - 1- (2-Fluoro-4-hydroxyphenyl) -2- [4- (1-benzimidazolyl) -2 -methyl-2-butylamino] ethanol [00238] - 1 - [3- (4-methoxybenzylamino) -4-hydroxyphenyl] -2- [4- (1-bis nzimidazolyl) -2-methyl-2-butylamino] ethanol 25/73

Merreux-ts pitesiasnt [00239] - [00240] - [00241] - [00242] - [00243] - [00244] - [00245] - [00246] - [00247] - [00248] - [00249] - [00250 ] - [00251] - [00252] - [00253] - [00254] - [00255] - [00256] - [00257] - [00258] - [00259] - [00260] - [00261] - [00262] - AT13 748U1 2014-08-15 1 - [2H-5-Hydroxy-3-oxo-4H-1,4-benzoxazin-8-yl] -2- [3- (4-N, N-dimethylaminophenyl) -2- methyl-2-propylamino] ethanol 1- [2H-5-hydroxy-3-oxo-4H-1,4-benzoxazin-8-yl] -2- [3- (4-methoxyphenyl) -2-methyl-2- propylamino] ethanol 1- [2H-5-hydroxy-3-oxo-4H-1,4-benzoxazin-8-yl] -2- [3- (4-n-butyloxyphenyl) -2-methyl-2-propylamino] ethanol 1- [2H-5-hydroxy-3-oxo-4H-1,4-benzoxazin-8-yl] -2- {4- [3- (4-methoxyphenyl) -1,2,4-triazole-3 -yl] -2-methyl-2-butylamino} -ethanol 5-hydroxy-8- (1-hydroxy-2-isopropylaminobutyl) -2H-1,4-benzoxazine-3- (4H) -one 1- (4-amino 3-chloro-5-trifluoromethylphenyl) -2-tert-butylamino) ethanol 6-hydroxy-8- {1-hydroxy-2- [2- (4-methoxyphenyl) -1,1-dimethylethylamino] -ethyl} - 4H-benzo [1,4] oxazin-3-one 6-hydroxy-8- {1-hydroxy-2 - [2- (ethyl-4-phenoxyacetate) -1,1-dimethylethylamino] -ethyl} -4 H -benzo [1,4] oxazin-3-one 6-hydroxy-8- {1-hydroxy-2- [2 - (4-phenoxyacetic acid) -1,1-dimethylethylamino] -ethyl} -4 H -benzo [1,4] oxazin-3-one 8- {2- [1,1-dimethyl-2- (2,4,6 -trimethylphenyl] ethylamino] -1-hydroxyethyl} -6-hydroxy-4H-benzo [1,4] oxazin-3-one 6-hydroxy-8- {1-hydroxy-2- [2- (4-hydroxyphenyl) -1,1-dimethylethylamino] ethyl} -4 H -benzo [1,4] oxazin-3-one 6-hydroxy-8- {1-hydroxy-2- [2- (4-isopropylphenyl) -1,1- dimethylethylamino] ethyl) -4H-benzo [1,4] oxazin-3-one 8- {2- [2- (4-ethylphenyl) -1,1-dimethylethylamino] -1-hydroxyethyl} -6-hydroxy-4H benzo [1,4] oxazin-3-one 8- {2- [2- (4-ethoxyphenyl) -1,1-dimethylethylamino] -1-hydroxyethyl} -6-hydroxy-4H-benzo [1,4] oxazin-3-one 4- (4- {2- [2-hydroxy-2- (6-hydroxy-3-oxo-3,4-dihydro-2H-benzo [1,4] oxazin-8-yl) - ethylamino] -2-methylpropyl} -phenoxy) -butyric acid 8- {2- [2- (3,4-difluorophenyl) -1,1-dimethylethylamino] -1-hydroxyethyl} -6-hydroxy-4H-benzo [1, 4] oxazin-3-one 1- (4-ethoxycarbonylamino-3-cyano-5-fluorophenyl) -2- (tert. -butylamino) ethanol 2-hydroxy-5- (1-hydroxy-2- {2- [4- (2-hydroxy-2-phenylethylamino) -phenyl] -ethylamino} -ethyl) -benzaldehyde N- [2-hydroxy- 5- (1-hydroxy-2- {2- [4- [2-hydroxy-2-phenylethylamino) -phenyl] ethylamino} -ethyl) -phenyl] -formamide 8-hydroxy-5- (1-hydroxy-2 - {2- [4- (6-methoxy-biphenyl-3-ylamino) -phenyl] -ethylamino} -ethyl) -1H-quinolin-2-one 8-hydroxy-5- [1-hydroxy-2- (6-phenethylamino -hexylamino) -ethyl] -1H-quinolin-2-one 5- [2- (2- {4- [4- (2-amino-2-methylpropoxy) -phenylamino] -phenyl} -ethylamino) -1-hyd Roxyethyl] -8-hydroxy-1H-quinolin-2-one [3- (4- {6- [2-hydroxy-2- (4-hydroxy-3-hydroxymethylphenyl) -ethylamino] -hexyloxy} -butyl) - 5-methylphenyl] urea 4- (2- {6- [2- (2,6-dichlorobenzyloxy) -ethoxy] -hexylamino} -1-hydroxyethyl) -2-hydroxymethyl-phenol 26/73

Patent Office AT 13 748 U1 2014-08-15 [00263] - 3- (4- {6- [2-Hydroxy-2- (4-hydroxy-3-hydroxymethylphenyl) -ethylamino] -hexyloxy } - butyl) benzylsulfonamide - 3- (3- {7- [2-hydroxy-2- (4-hydroxy-3-hydroxymethylphenyl) -ethylamino] -heptyloxy} -propyl) -benzylsulfonamide [00265] - 4 - (2- {6- [4- (3-cyclopentanesulfonylphenyl) -butoxy] -hexylamino} -1-hydroxyethyl) -2-hydroxymethylphenol - N-adamantan-2-yl-2- (3- {2- [2-hydroxy-2- (4-hydroxy-3-hydroxymethylphenyl) ethylamino] -propyl} -phenyl) -acetamide, optionally in the form of their racemates, enantiomers, diastereomers and, where appropriate, in the form of their pharmacologically acceptable acid addition salts, Sol -vate or hydrates. According to the invention, the acid addition salts of the betamimetics are preferably selected from the group consisting of hydrochloride, hydrobromide, hydroiodide, hydrosulfate, hydrophosphate, hydromethanesulfonate, hydronitrate, hydromaleate, hydroacetate, hydrocitrate, hydrofumarate, hydrotartrate, hydroxalate, hydrosuccinate, hydrobenzoate and hydro-p-hydroxybenzate. toluenesulfonate exists.

The anticholinergic agents used are preferably compounds selected from the Tio-tropiumsalzen, preferably the bromide salt, Oxitropiumsalzen, preferably the bromide salt, Flutropiumsalzen, preferably the bromide salt, Ipratropiumsalzen, preferably the bromide salt, Glycopyrroniumsalzen, preferably the bromide salt, Trospiumsalzen, preferably the chloride salt , Tolterodine be selected. In the above-mentioned salts, the cations are the pharmacologically active ingredients. As anions, the abovementioned salts may preferably contain the chloride, bromide, iodide, sulfate, phosphate, methanesulphonate, nitrate, maleate, acetate, citrate, fumarate, tartrate, oxalate, succinate, benzoate or p-toluenesulphonate, chloride, bromide , iodide, sulfate, methanesulfonate or p-toluenesulfonate are preferred as counterions. Of all the salts, the chlorides, bromides, iodides and methanesulfonates are particularly preferred.

Other preferred anticholinergics are selected from the salts of formula AC-1

Wherein X- is an anion having a negative unit charge, preferably an anion of fluoride, chloride, bromide, iodide, sulfate, phosphate, methanesulfonate, nitrate, maleate, acetate, citrate, fumarate, tartrate, oxalate, succinate , Benzoate and p-toluenesulfonate, preferably an anion having a negative unit charge, more preferably an anion selected from fluoride, chloride, bromide, methanesulfonate and p-toluenesulfonate, more preferably bromide, optionally in the form of their racemates, enantiomers or hydrates, is selected. Of particular importance are drug combinations containing the enantiomers of the formula AC-1-ene

[00271] where X - may have the meanings given above. Other preferred anticholinergics are selected from the salts of formula AC-2 27 173

& ^^^^^^^^^^^^^^^^^^^^^^^^^^^^ AT 13 748 U1 2014-08-15 u

X '

AM t [00272] where R is either methyl or ethyl and where X- may have the meanings given above. In an alternative embodiment, the compound of the formula AC-2 may also be present in the form of the free base AC-2-base. AC-2-biut [00276] [00277] [00277] [00278] [00279] [00280] [00281] [00282] [00283] [00284] [00285] [00286] [00287] [00289] [00290] [00291] [00292] [00293] [00294] [00295] [00296] [00297] [00298] [00299]

Further specified compounds are: 2,2-Diphenylpropionsäuretropenolester methobromide, 2,2-Diphenylpropionsäurescopinester methobromide, 2-fluoro-2,2-diphenylessigsurescopinester methobromide, 2-fluoro-2,2-diphenylessigsäuretropenolester methobromide, 3,3,4,4'-tetrafluorobenzilic acid-tropol ester-methobromide, 3,3 ', 4,4'-tetrafluorobenzilate copoprene methobromide, 4,4'-difluorobenzilic acid-tropol ester-methobromide, 4,4'-difluorobenzilic acid copoprene-methobromide, - 3 '3'-Difluorobenzylic acid tropol ester methobromide, 3,3'-difluorobenzilic acid copoprene methobromide, 9-hydroxyfluorene-9-carboxylic acid-tropol ester-methobromide, 9-fluorofluorene-9-carboxylic acid-tropol ester-methobromide, 9-hydroxyfluorene-9-carboxylic acid-co-ester methobromide , - 9-fluorofluorene-9-carboxylic acid-copinester-methobromide, - 9-methylfluorene-9-carboxylic acid-tropol ester-methobromide, - 9-methylfluorene-9-carboxylic acid-copinester-methobromide, - Benzilic acid-cyclopropyl-tropine ester-methobromide, - 2,2-diphenyl propionic acid cyclopropyltropine ester methobromide, - 9-hydroxyxanthene-9-carboxylic acid cyclopropyltropine ester methobromide, - 9-methylfluorene-9-carboxylic acid cyclopropyltropine ester methobromide, - 9-methylxanthene-9-carboxylic acid cyclopropyltropine ester methobromide, - 9-hydroxyfluorene-9-carboxylic acid cyclopropyltropine ester methobromide, - 4 Methyl 4'-difluorobenzilate cyclopropyltropine ester methobromide; 9-hydroxyxanthene-9-carboxylic acid tropol ester methobromide; 9-hydroxyxanthene-9-carboxylic acid copolyester methobromide; 9-methylxanthene-9-carboxylic acid tropol ester methobromide, 28/73

[00300] - 9-methylxanthene-9-carboxylic acid copoprene methobromide, 9-ethylxanthene-9-carboxylic acid-tropol ester-methobromide, [00302] 9-difluoromethylxanthene -9-carboxylic acid tropol ester methobromide, 9-hydroxymethylxanthene-9-carboxylic acid copoester methobromide.

In the context of the present invention, the abovementioned compounds can also be used as salts in which the salts Metho-X are used instead of the methobromide, where X may have the meanings given above for X-.

The corticosteroids used are preferably compounds selected from beclomethasone, betamethasone, budesonide, butixocort, ciclesonide, deflazacort, dexamethasone, etiprednol, flunisolide, fluticasone, loteprednol, mometasone, prednisolone, prednisone, rofleponide, triamcinolone, RPR-106541, NS-126, ST-26 and [00306] - 6,9-Difluoro-17- (2-furanylcarbonyl) oxy] -11-hydroxy-16-methyl-3-oxo-androsta-1,4-diene-17- carbothionic acid (S) -fluoromethyl ester - 6,9-difluoro-11-hydroxy-16-methyl-3-oxo-17-propionyloxy-androsta-1,4-diene-17-carbothionic acid (S) - (2- oxotetrahydrofuran-3S-yl) esters, [00308] 6a, 9a-difluoro-11β-hydroxy-16a-methyl-3-oxo-17a (2,2,3,3-tertamethylcyclopropylcarbonyl) oxy-androsta-1, 4-diene-17β-carboxylic acid cyanomethyl ester, optionally in the form of their racemates, enantiomers or diastereomers and optionally in the form of their salts and derivatives, their solvates and / or hydrates. Any reference to steroids includes reference to any existing salts or derivatives, hydrates or solvates. Examples of possible salts and derivatives of steroids are u. a .: alkali metal salts, such as sodium or potassium salts, sulfobenzoates, phosphates, Isonicoti-nate, acetates, dichloroacetates, propionates, dihydrogen phosphates, palmitates, pivalates or furoates.

PDE4 inhibitors which may be used are preferably compounds selected from enprofylline, theophylline, roflumilast, ariflo (cilomilast), tofimilast, pumaf-entrin, lirimilast, arofylline, atizoram, D-4418, bay-198004 , BY343, CP-325.366, D-4396 (Sch-351591), AWD-12-281 (GW-842470), NCS-613, CDP-840, D-4418, PD-168787, T-440, T-2585 , V-11294A, CI-1018, CDC-801, CDC-3052, D-22888, YM-58997, Z-15370 and [00311] - N- (3,5-dichloro-1-oxopyridin-4-yl) 4-difluoromethoxy-3-cyclopropylmethoxybenzamide [00312] - (-) p - [(4aR *, 10bS *) - 9-ethoxy-1,2,3,4,4a, 10b-hexahydro-8-methoxy-2- methylbenzo [s] [1,6] naphthyridin-6-yl] -N, N'-diisopropylbenzamide [00313] - (R) - (+) - 1- (4-bromobenzyl) -4 - [(3-cyclopentyloxy) - 4-methoxyphenyl] -2-pyrrolidone [00314] - 3- (cyclopentyloxy-4-methoxyphenyl) -1- (4-N '- [N-2-cyano-S-methylisothioureido] benzyl) -2-pyrrolidone [00315] - cis [4-cyano-4- (3-cyclopentyloxy-4-methoxyphenyl) cyclohexane-1-carboxylic acid] [00316] - 2-carbomethoxy-4-cyano-4- (3-cyclopropylme thoxy-4-difluoromethoxyphenyl) cyclohexan-1-one [00317] - cis [4-cyano-4- (3-cyclopropylmethoxy-4-difluoromethoxyphenyl) cyclohexan-1-ol] [00318] - (R) - (+) - Ethyl [4- (3-cyclopentyloxy-4-methoxyphenyl) pyrrolidin-2-ylidene] acetate [00319] - (S) - (-) - Ethyl [4- (3-cyclopentyloxy-4-methoxyphenyl) pyrrolidin-2-ylidene ] acetate [00320] - 9-Cyclopentyl-5,6-dihydro-7-ethyl-3- (2-thienyl) -9H-pyrazolo [3,4-c] -1,2,4-triazolo [4.3-a] pyridine 29/73

SförreicNäCses psttüte * AT 13 748 U1 2014-08-15 - 9-cyclopentyl-5,6-dihydro-7-ethyl-3- (tert-butyl) -9H-pyrazolo [3,4-c] -1, 2,4-triazolo [4.3-a] pyridine, optionally in the form of their racemates, enantiomers or diastereomers and optionally in the form of their pharmacologically acceptable acid addition salts, their solvates and / or hydrates. According to the invention, the acid addition salts of the PDE4 inhibitors are preferably selected from the hydrochloride, hydrobromide, hydroiodide, hydrosulfate, hydrophosphate, hydromethanesulfonate, hydronitrate, hydromaleate, hydroacetate, hydrocitrate, hydrofumarate, hydrotartrate, hydroxalate, hydrosuccinate, hydrobenzoate and hydro-p-toluenesulfonate.

The LTD4 antagonists used are preferably compounds selected from montelukast, pranlukast, zafirlukast, MCC-847 (ZD-3523), MN-001, MEN-91507 (LM-1507), VUF-5078, VUF- K-8707, L-733321 and [00324] - 1 - (((R) - (3- (2- (6,7-Difluoro-2-quinolinyl) ethenyl) phenyl) -3- (2- (2- hydroxy-2-propyl) phenyl) thio) methylcyclopropaneacetic acid, [00325] - 1 - (((1 (R) -3 (3- (2- (2,3-dichlorothieno [3,2-b] pyridine-5-) yl) - (E) -ethenyl) phenyl) -3- (2- (1-hydroxy-1-methylethyl) phenyl) propyl) thio) methyl) cyclopropaneacetic acid, [00326] - 2 - [[2- (4- tert-butyl-2-thiazolyl) -5-benzofuranyl] oxymethyl] phenyl] -acetic acid, optionally in the form of their racemates, enantiomers or diastereomers and optionally in the form of their pharmacologically acceptable acid addition salts, solvates and / or hydrates the acid addition salts of the LTD4 antagonists preferably from the hydrochloride, hydrobromide, hydroiodide, hydrosulfate, hydrophosphate, hydromethanesulfonate, hydronitrile at, hydromaleate, hydroacetate, hydrocitrate, hydrofumarate, hydrotartrate, hydroxalate, hydrosuccinate, hydrobenzoate and hydro-p-toluenesulfonate. Among salts or derivatives which may optionally form the LTD4-antagonists are, for example, the following: alkali metal salts, such as sodium or potassium salts, alkaline earth metal salts, sulfobenzoates, phosphates, isonicotinates, acetates, propionates, dihydro genphosphate, palmitates, pivalates or furoate.

EGFR inhibitors which may be used are preferably compounds selected from cetuximab, trastuzumab, ABX-EGF, Mab ICR-62 and [00329] 4 - [(3-chloro-4-fluorophenyl) amino ] -6 - {[4- (morpholin-4-yl) -1-oxo-2-buten-1-yl] amino} -7-cyclopropylmethoxyquinazoline [00330] 4 - [(3-chloro-4-fluorophenyl) amino] -6 - {[4- (N, N-diethylamino) -1-oxo-2-buten-1-yl] amino} -7-cyclopropylmethoxyquinazoline [00331] 4 - [(3-chloro-4-fluorophenyl ) amino] -6 - {[4- (N, N-dimethylamino) -1-oxo-2-buten-1-yl] amino} -7-cyclopropylmethoxyquinazoline [00332] - 4 - [(R) - (1- Phenylethyl) amino] -6 - {[4- (morpholin-4-yl) -1-oxo-2-buten-1-yl] amino} -7-cyclopentyloxyquinazoline [00333] - 4 - [(3-chloro-4 -fluorophenyl) amino] -6 - {[4 - ((R) -6-methyl-2-oxomorpholin-4-yl) -1-oxo-2-buten-1-yl] amino} -7-cyclopropylmethoxyquinazoline [00334 ] - 4 - [(3-chloro-4-fluorophenyl) amino] -6 - {[4 - ((R) -6-methyl-2-oxomorpholin-4-yl) -1-oxo-2-butene-1 -yl] amino} -7 - [(S) - (tetrahydrofuran-3-yl) oxy] quinazoline [00335] - 4 - [(3-chloro-4-fluorophenyl) amino] -6 - {[ 4 - ((R) -2-methoxymethyl-6-oxomorpholin-4-yl) -1-oxo-2-buten-1-yl] amino] -7-cyclopropylmethoxyquinazoline [00336] - 4 - [(3-chloro) 4-fluorophenyl) amino] -6- [2 - ((S) -6-methyl-2-oxomorpholin-4-yl) -ethoxy] -7-methoxyquinazoline [00337] - 4 - [(3-chloro-4- fluorophenyl) amino] -6 - ({4- [N- (2-methoxyethyl) -N-methylamino] -1-oxo-2-buten-1-yl} amino) -7-cyclopropylmethoxyquinazoline 30/73

MerrecfcLvche ;; AT13 748U1 2014-08-15 [00338] - 4 - [(3-Chloro-4-fluorophenyl) amino] -6 - {[4- (N, N-dimethylamino) -1-oxo-2-butene-1 yl] amino} -7-cyclopentyloxyquinazoline - [00339] 4 - [(R) - (1-Phenylethyl) amino] -6 - {[4- (N, N-bis (2-methoxyethyl) amino] -1 -oxo-2-buten-1-yl] amino} -7-cyclopropylmethoxyquinazoline [00340] - 4 - [(R) - (1-phenylethyl) amino] -6 - ({4- [N- (2-methoxyethyl) -N-ethylamino] -1-oxo-2-buten-1-yl} amino) -7-cyclopropylmethoxyquinazoline - 4 - [(R) - (1-phenylethyl) amino] -6 - ({4- [ N- (2-methoxyethyl) -N-methylamino] -1-oxo-2-buten-1-yl} amino) -7-cyclopropylmethoxyquinazoline - 4 - [(R) - (1-phenylethyl) amino] - 6 - ({4- [N- (tetrahydropyran-4-yl) -N-methylamino] -1-oxo-2-buten-1-yl} amino) -7-cyclopropylmethoxyquinazoline [00343] - 4 - [(3 Chloro-4-fluorophenyl) amino] -6 - ({4- (N, N-dimethylamino) -1-oxo-2-buten-1-yl] amino} -7 - ((R) -tetrahydrofuran-3-yloxy ) -quinazoline [00344] - 4 - [(3-chloro-4-fluorophenyl) amino] -6 - {[4- (N, N-dimethylamino) -1-oxo-2-buten-1-yl] amino} -7 - ((S) -tetrahydrofuran-3-yloxy) quinazoline [00345] - 4 - [(3-chloro r-4-fluorophenyl) amino] -6 - ({4- [N- (2-methoxyethyl) -N-methylamino] -1-oxo-2-buten-1-yl} amino] -7-cyclopentyloxyquinazoline [00346] - 4 - [(3-chloro-4-fluorophenyl) amino] -6 - {[4- (N-cyclopropyl-N-methylamino) -1-oxo-2-buten-1-yl] amino} -7-cyclopentyloxyquinazoline 4 - [(3-chloro-4-fluorophenyl) amino] -6 - {[4- (N, N-dimethylamino) -1-oxo-2-buten-1-yl] amino} -7- (R) - (tetrahydrofuran-2-yl) methoxy] quinazoline [00348] - 4 - [(3-chloro-4-fluorophenyl) amino] -6 - {[4- (N, N-dimethylamino) -1- oxo-2-buten-1-yl] amino} -7 - [(S) - (tetrahydrofuran-2-yl) methoxy] quinazoline [00349] - 4 - [(3-ethynylphenyl) amino] -6,7- bis (2-methoxyethoxy) quinazoline [00350] - 4 - [(3-chloro-4-fluorophenyl) amino] -7- [3- (morpholin-4-yl) -propyloxy] -6- (vinylcarbonyl ) amino] quinazoline - 4 - [(R) - (1-phenylethyl) amino] -6- (4-hydroxyphenyl) -7H-pyrrolo [2,3-d] pyrimidine [00352] 3-cyano 4 - [(3-chloro-4-fluorophenyl) amino] -6 - {[4- (N, N-dimethylamino) -1-oxo-2-buten-1-yl] amino} -7-ethoxyquinoline [00353 ] - 4- {3-Chloro-4- (3-fluoro-benzyloxy) -phenyl] -amino} -6- (5 - {[(2 - methanesulfonylethyl) amino] methyl} furan-2-yl) quinazoline - 4 - [(R) - (1-phenylethyl) amino] -6 - {[4 - ((R) -6-methyl] 2-oxomorpholin-4-yl) -1-oxo-2-buten-1-yl] amino} -7-methoxyquinazoline [00355] - 4 - [(3-chloro-4-fluorophenyl) amino] -6 - {[ 4- (morpholin-4-yl) -1-oxo-2-buten-1-yl] amino} -7- (tetrahydrofuran-2-yl) methoxy] quinazoline [00356] - 4 - [(3-chloro) 4-fluorophenyl) amino] -6 - ({4- [N, N-bis (2-methoxyethyl) amino] -1-oxo-2-buten-1-yl} amino) -7 - [(tetrahydrofuran 2-yl) methoxy] quinazoline - [4- (3-ethynylphenyl) amino] -6 - {[4- (5,5-dimethyl-2-oxomorpholin-4-yl) -1-oxo-2 -but-1-yl] amino} quinazoline - 4 - [(3-chloro-4-fluorophenyl) amino] -6- [2- (2,2-dimethyl-6-oxomorpholin-4-yl) -ethoxy] -7-methoxyquinazoline [00359] - 4 - [(3-chloro-4-fluorophenyl) amino] -6- [2- (2,2-dimethyl-6-oxomorpholin-4-yl) -ethoxy] - 7- [(R) - (tetrahydrofuran-2-yl) methoxy] quinazoline [00360] - 4 - [(3-chloro-4-fluorophenyl) amino] -7- [2- (2,2-dimethyl-6 -oxomorpholin-4-yl) -ethoxy] -6- [(S) - (tetrahydrofuran-2-yl) methoxy] -quinazoline 31/73

asterrebeBe pitwiarot AT 13 748 U1 2014-08-15 [00361] - 4 - [(3-Chloro-4-fluorophenyl) amino] -6- {2- [4- (2-oxomorpholin-4-yl) -piperidine] 1-yl] ethoxy} -7-methoxyquinazoline [00362] - 4 - [(3-chloro-4-fluorophenyl) amino] -6- [1- (tert-butyloxycarbonyl) -piperidin-4-yloxy] -7 - methoxyquinazoline [00363] - 4 - [(3-chloro-4-fluorophenyl) amino] -6- (trans-4-aminocyclohexan-1-yloxy) -7-methoxyquinazoline [00364] - 4 - [(3-chloro) 4-fluorophenyl) amino] -6- (trans-4-methanesulfonylaminocyclohexan-1-yloxy) -1-methoxyquinazoline [00365] - 4 - [(3-chloro-4-fluorophenyl) amino] -6- (tetrahydropyran-3-) yloxy) -7-methoxyquinazoline [00366] - 4 - [(3-chloro-4-fluorophenyl) amino] -6- (1-methylpiperidin-4-yloxy) -7-methoxyquinazoline [00367] - 4 - [(3 Chloro-4-fluorophenyl) amino] -6- {1 - [(morpholin-4-yl) carbonyl] -piperidin-4-yloxy} -7-methoxyquinazoline [00368] -4- [(3-chloro-4-fluorophenyl ) amino] -6- {1 - [(methoxymethyl) carbonyl] -piperidin-4-yloxy} -7-methoxyquinazoline [00369] - 4 - [(3-chloro-4-fluorophenyl) amino] -6- (piperidine) 3-yloxy) -7-methoxyquinazoline [00370] - 4 - {(3-chloro-4-fluorophenyl) amino] -6- [1- (2-acetylaminoethyl) -piperidin-4-yloxy] -7-methoxyquinazoline - 4 - [(3-chloro-4 -fluorophenyl) amino] -6- (tetrahydropyran-4-yloxy) -7-ethoxyquinazoline - 4 - [(3-chloro-4-fluorophenyl) amino] -6 - ((S) -tetrahydrofuran-3-yloxy ) -7-hydroxyquinazoline - [4- (3-chloro-4-fluorophenyl) amino] -6- (tetrahydropyran-4-yloxy) -7- (2-methoxyethoxy) -quinazoline [00374] 4- [ (3-Chloro-4-fluorophenyl) amino] -6- {trans-4 - [(dimethylamino) sulfonylamino] -cyclohexan-1-yloxy} -7-methoxyquinazoline [00375] - 4 - [(3-chloro-4- fluorophenyl) amino] -6- {trans-4 - [(morpholin-4-yl) carbonylamino] -cyclohexan-1-yloxy} -7-methoxyquinazoline - 4 - [(3-chloro-4-fluorophenyl) amino ] -6- {trans-4 - [(morpholin-4-yl) sulfonylamino] -cyclohexan-1-yloxy} -7-methoxyquinazoline - [4- (3-chloro-4-fluorophenyl) amino] -6 - (tetrahydropyran-4-yloxy) -7- (2-acetylaminoethoxy) quinazoline - [4- (3-chloro-4-fluorophenyl) amino] -6- (tetrahydropyran-4-yloxy) -7- ( 2-methanesulfonylaminoethoxy) quinazoline [00379] 4-[(3-chloro-4-fluorophenyl) amino] -6- {1 - [(piperidin-1-yl) carbonyl] -piperidin-4-yloxy} -7-methoxyquinazoline [00380] - 4 - [( 3-chloro-4-fluorophenyl) amino] -6- (1-aminocarbonylmethylpiperidin-4-yloxy) -7-methoxyquinazoline - 4 - [(3-chloro-4-fluorophenyl) amino] -6- (cis) 4- {N - [(tetrahydropyran-4-yl) carbonyl] -N-methylamino} -cyclohexan-1-yloxy) -7-methoxyquinazoline - 4 - [(3-chloro-4-fluorophenyl) amino] - 6- (Cis-4- {N - [(morpholin-4-yl) carbonyl] -N-methylamino} -cyclohexan-1-yloxy) -7-methoxyquinazoline [00383] - 4 - [(3-Chloro-4- fluorophenyl) amino] -6- (cis-4- {N - [(morpholin-4-yl) sulfonyl] -N-methylamino} -cyclohexan-1-yloxy) -7-methoxyquinazoline - 4 - [(3 -Chloro-4-fluorophenyl) amino] -6- (trans-4-ethanesulfonylaminocyclohexan-1-yloxy) -7-methoxyquinazoline 32/73

AT13 748U1 2014-08-15 [00385] - 4 - [(3-Chloro-4-fluoro-phenyl) -amino] -6- (1-methanesulfonyl-piperidin-4-yloxy) -7-ethoxy-quinazoline [38 *] 00386] - 4 - [(3-chloro-4-fluorophenyl) amino] -6- (1-methanesulfonyl-piperidin-4-yloxy) -7- (2-methoxy-ethoxy) -quinazoline [00387] - 4 - [(3-Chloro 4-fluorophenyl) amino] -6- [1- (2-methoxyacetyl) -piperidin-4-yloxy] -7- (2-methoxyethoxy) quinazoline - [4- (3-chloro-4-fluorophenyl ) amino] -6- (cis-4-acetylaminocyclohexan-1-ylxy) -7-methoxyquinazoline [00389] - 4 - [(3-ethynylphenyl) amino] -6- [1- (tert-butyloxycarbonyl) -piperidine] 4-yloxy] -7-methoxyquinazoline [00390] - 4 - [(3-ethynylphenyl) amino] -6- (tetrahydropyran-4-yloxy) -7-methoxyquinazoline - 4 - [(3-chloro-4- fluorophenyl) amino] -6- (cis-4- {N - [(piperidin-1-yl) carbonyl] -N-methylamino} -cyclohexan-1-yloxy) -7-methoxyquinazoline - 4 - [(3 -Chloro-4-fluorophenyl) amino] -6- (cis-4- {N - [(4-methylpiperazin-1-yl) carbonyl] -N-methylamino} -cyclohexan-1-yloxy) -7-methoxyquinazoline [00393 ] - 4 - [(3-chloro-4-fluorophenyl) amine o] -6- {cis-4- (morpholin-4-yl) carbonylamino] -cyclohexan-1-yloxy} -7-methoxyquinazoline - 4 - [(3-chloro-4-fluorophenyl) amino] -6 - {1- [2- (2-oxopyrrolidin-1-yl) ethyl] piperidin-4-yloxy} -7-methoxyquinazoline [00395] - 4 - [(3-chloro-4-fluorophenyl) amino] -6- {1 - [(morpholin-4-yl) carbonyl] piperidin-4-yloxy} -7- (2-methoxyethoxy) quinazoline - 4 - [(3-ethynylphenyl) amino] -6- (1) acetylpiperidin-4-yloxy) -7-methoxyquinazoline - 4 - [(3-ethynylphenyl) amino] -6- (1-methylpiperidin-4-yloxy) -7-methoxyquinazoline [00398] - 4 - [(3 Ethynylphenyl) amino] -6- (1-methanesulfonyl-piperidin-4-yloxy) -7-methoxyquinazoline [00399] - 4 - [(3-chloro-4-fluorophenyl) amino] -6- (1-methylpiperidin-4-yloxy) -7 (2-methoxyethoxy) quinazoline - 4 - [(3-chloro-4-fluorophenyl) amino] -6- (1-isopropyloxycarbonylpiperidin-4-yloxy) -7-methoxyquinazoline [00401] 4- [ (3-Chloro-4-fluorophenyl) amino] -6- (cis-4-methylaminocyclohexan-1-yloxy) -7-methoxyquinazoline [00402] - 4 - [(3-chloro-4-fluorophenyl) amino} -6- {cis-4- [N- (2-methoxyacetyl) -N-methyla mino] - cyclohexan-1-yloxy} -7-methoxyquinazoline - [00403] 4 - [(3-ethynylphenyl) amino] -6- (piperidin-4-yloxy) -7-methoxyquinazoline [00404] 4 - [(3 Ethynylphenyl) amino] -6- [1- (2-methoxyacetyl) -piperidin-4-yloxy] -7-methoxyquinazoline [00405] 4 - [(3-ethynylphenyl) amino] -6- {1 - [(morpholine 4-yl) carbonyl] -piperidin-4-yloxy} -7-methoxyquinazoline [00406] - 4 - [(3-chloro-4-fluorophenyl) amino] -6- {1 - [(cis-2,6- dimethylmorpholin-4-yl) carbonyl] -piperidin-4-yloxy} -7-methoxyquinazoline [00407] - 4 - [(3-chloro-4-fluorophenyl) amino] -6- {1- (2-methylmorpholine-4-yl) yl) carbonyl] -piperidin-4-yloxy} -7-methoxyquinazoline [00408] - 4 - [(3-chloro-4-fluorophenyl) amino] -6- {1 - [(S, S) - (2-oxa -5-azabicyclo [2.2.1] hept-5-yl) carbonyl] -piperidin-4-yloxy} -7-methoxyquinazoline 33/73

SsferRÄctits psteK & ffit AT 13 748 U1 2014-08-15 [00409] - 4 - [(3-Chloro-4-fluorophenyl) amino] -6- {1 - [(N-methyl-N-2-methoxyethylamino) carbonyl ] - piperidin-4-yloxy} -7-methoxyquinazoline [00410] - 4 - [(3-chloro-4-fluorophenyl) amino] -6- (1-ethyl-piperidin-4-yloxy) -7-methoxy-quinazoline [00411 ] - 4 - [(3-chloro-4-fluorophenyl) amino] -6- {1 - [(2-methoxyethyl) carbonyl] -piperidin-4-yloxy} -7-methoxyquinazoline [00412] - 4 - [(3 -Chloro-4-fluorophenyl) amino] -6- {1 - [(3-methoxypropylamino) -carbonyl] -piperidin-4-yloxy} -7-methoxyquinazoline [00413] -4- [(3-chloro-4-fluorophenyl ) amino] -6- [cis-4- (N-methanesulfonyl-N-methylamino) -cyclohexan-1-yloxy] -7-methoxyquinazoline [00414] - 4 - [(3-chloro-4-fluorophenyl) amino} - 6- [cis-4- (N-acetyl-N-methylamino) -cyclohexan-1-yloxy] -7-methoxyquinazoline [00415] - 4 - [(3-chloro-4-fluorophenyl) amino] -6- (trans 4-methylaminocyclohexan-1-yloxy) -7-methoxyquinazoline [00416] - 4 - [(3-chloro-4-fluorophenyl) amino] -6- [trans-4- (N-methanesulfonyl-N-methylamino) -cyclohexane 1-yloxy] -7-methoxyquinazoline [00417] - 4 - [(3-chloro-4-fluorophenyl) amino] -6- (trans-4-dimethylaminocyclohexan-1-yloxy) -7-methoxyquinazoline [00418] 4 - [(3-chloro-4-fluorophenyl) amino ] -6- (trans-4- {N - [(morpholin-4-yl) carbonyl] -N-methylamino} -cyclohexan-1-yloxy) -7-methoxyquinazoline [00419] - 4 - [(3 Chloro-4-fluorophenyl) amino] -6- [2- (2,2-dimethyl-6-oxomorpholin-4-yl) ethoxy] -7- [(S) - (tetrahydrofuran-2-yl) methoxy] - quinazoline [00420] - 4 - [(3-chloro-4-fluorophenyl) amino] -6- (1-methanesulfonyl-piperidin-4-yloxy) -7-methoxy-quinazoline [00421] 4 - [(3-chloro-4-fluorophenyl ) amino] -6- (1-cyanopiperidin-4-yloxy) -7-methoxyquinazoline [00422] optionally in the form of their racemates, enantiomers, diastereomers and optionally in the form of their pharmacologically acceptable acid addition salts, solvates or hydrates. According to the invention, the acid addition salts of the EGFR inhibitors are preferably selected from the hydrochloride, hydrobromide, hydroiodide, hydrosulfate, hydrophosphate, hydromethanesulfonate, hydronitrate, hydromaleate, hydroacetate, hydrocitrate, hydrofumarate, hydrotartrate, hydroxoate, hydrosuccinate, hydrobenzoate and hydro-p-toluenesulfonate selected.

The dopamine agonists used are preferably compounds selected from bromocriptine, cabergoline, alpha-dihydroergocryptine, lisuride, pergolide, pramipexole, roxindole, ropi-nirol, talipexole, terguride and viozane, optionally in the form of their racemates, enantiomers, diastereomers and optionally in the form of their pharmacologically acceptable acid addition salts, solvates or hydrates. In the present invention, the acid addition salts of the dopamine agonists are preferably selected from the hydrochloride, hydrobromide, hydroiodide, hydrosulfate, hydrophosphate, hydromethanesulfonate, hydronitrate, hydromaleate, hydroacetate, hydrocitrate, hydrofumarate, hydrotartrate, hydroxalate, hydrosuccinate, hydrobenzoate and hydro-p-toluenesulfonate.

Useful H1 antihistamines are preferably compounds derived from epinastine, cetirizine, azelastine, fexofenadine, levocabastine, loratadine, mizolastine, ketotifen, emedastine, dimetindene, clemastine, bamipine, cexchlorpheniramine, pheniramine, doxylamine, chlorphenoxamine, dimenhydrinate, diphenhydramine , Promethazine, ebastine, desloratidine and meclocine, optionally in the form of their racemates, enantiomers, diastereomers and optionally in the form of their pharmacologically acceptable acid addition salts, solvates or hydrates. According to the invention, the acid addition salts of the H1-antihistamines are preferably selected from the hydrochloride, hydrobromide, hydroiodide, hydrosulfate, hydrophosphate, hydromethanesulfonate, hydronitrate, hydromaleate, hydroacetate, hydrocitrate, hydrofumarate, hydrotartrate, hydrous

palsiaznt AT13 748U1 2014-08-15 xalate, hydrosuccinate, hydrobenzoate and hydro-p-toluenesulfonate.

It is also possible to use inhalable macromolecules, as disclosed in EP 1 003 478 A1 or CA 2297174 A1.

Furthermore, the compounds from the groups of the ergot alkaloid derivatives, the triptans, the CGRP inhibitors, the phosphodiesterase V inhibitors, optionally in the form of their racemates, enantiomers or diastereomers, optionally in the form of their pharmacologically acceptable acid addition salts, solvates and / or hydrates.

Examples of ergot alkaloid derivatives are dihydroergotamine and ergotamine.

Further aspects of the present invention are the following: The atomizer (1) for dispensing a formulation (2), in particular from a reservoir (3) with a number of preferably annularly arranged containers (4), each one Dose of the formulation (2) comprises a dispenser (5) for a release medium, in particular air, for dispensing the formulation (2) and / or an energy storage, in particular a spring accumulator, and an end piece or mouthpiece (8) for dispensing the formulation (2), in particular as an aerosol, and a manually movable cover (10) associated with the end piece or mouthpiece (8).

The dispensing medium may be pressurized and / or the dispenser (5) comprises or forms a pump.

The delivery device (5) comprises a bellows (7) for conveying, in particular pumps, the delivery medium.

The nebulizer (1) is constructed so that the discharge medium for discharging the formulation (2) can be pressurized by an energy storage or spring storage.

The nebulizer (1) for dispensing a formulation (2), in particular from a reservoir (3) with a number of preferably annularly arranged containers (4), each containing a dose of the formulation (2), comprises a final or mouthpiece (8) for dispensing the formulation (2), in particular as an aerosol, and a cover (10) belonging to the end or mouthpiece (8) and manually movable for opening and / or closing (10), and a translation or a gear (15), so that from the opening and / or closing movement of the cover (10) a preferably axial movement for opening the next container (4), for moving and / or advancing the reservoir (3), the Clamping of a spring accumulator, for actuating a dispensing device (5), in particular for the suction of air, and / or for actuating a counter (59) is generated.

By opening or closing the cover (10), a transport device (23) is actuated, as a result of which the reservoir (3) is advanced by one container (4).

The delivery device (5) comprises a bellows (7) for conveying, in particular pumps, the delivery medium.

[00436] The energy store is associated with the dispenser (5) or forms part of it.

The energy store or spring store surrounds the dispensing device (5) or is arranged or integrated therein.

The atomizer (1) has a preferably fixed and / or radially aligned end or mouthpiece (8) for dispensing the formulation (2), in particular as an aerosol.

The atomiser (1) has a central actuating element (21), which can be pressed in particular in the axial direction, for triggering the delivery of a dose of the formulation (2).

The atomizer (1) for dispensing a formulation (2), in particular from a Re 35/73

The reservoir (3) comprising a number of preferably annular containers (4), each containing a dose of the formulation (2), has a closable chamber (62) for receiving medicaments independent of the reservoir (3).

The atomizer (1) has a counter (59), in particular for displaying already dispensed or still available cans on.

The atomizer (1) has a clock generator (63), which is constructed in particular such that a preferably optical, acoustic and / or vibrating signal can be output as a reminder of the use of the atomizer (1).

The dispenser (5) and / or the connecting device (24) is / are linear, radial and / or movable in the manner of a carriage.

The dispenser (5) and / or the connecting device (24) is / are by means of a sliding guide (70, 75) movable, in particular slidable. 36/73 pitenEaist REFERENCE LIST: 1 Atomizer 2 Formulation 3 Reservoir 4 Reservoir 5 Dispenser 6 Pump chamber 7 Bellows 8 Mouthpiece 9 Grate 10 Cover 11 Dispensing direction 12 Axle 13 Housing 14 Spring 15 Transmission 16 Threaded sleeve 17 Internal thread 18 External thread 19 Inner engagement member 20 Locking arm 21 Actuator 22 Engaging element 23 transporting device 24 connecting device 25 outer engaging part 26 control cam 27 projection 27a notch 27b transport arm 28 insert 29 receiving chamber 30 opening 31 storage chamber 32 channel 33 fingers 34 connecting element 35 discharge channel 36 rotation stop 37 locking device 38 snap 39 control ring 40a locking arm 40b locking arm (housing)

AT 13 748U1 2014-08-15

§StCT "iÖ» 5id »S pitentäist 40c stop 40d stop arm 40e sliding surface 41 inner part 42 T räger 43 teeth 44 Gegenzahnung 45 peripheral opening 46 release mechanism 47 upper housing part 48 lower housing part 49 spring element 50 snap hook 51 annular shoulder 52 inlet 53 outlet 54 arrow 55 ring Carrier 56 Recess 57 Blocking device 58 Abutment 59 Counter 60 Scale 61 Window 62 Recess 63 Clock 64 Cover 65 Connecting channel 66 Pinion 67 Internal serration 68 Control 69 Axial engagement 70 First sliding guide 71 First engaging element 72 First section 73 Second section 74 Third section 75 Second sliding guide 76 Second Engaging element 77 abutment 78 shoulder 79 slide 80 radial section 81 holding section 38/73

Claims (15)

Merrecfcische ;; Claims 1. A nebulizer (1) for dispensing a formulation (2) from a reservoir (3) having a plurality of preferably annularly arranged containers (4) each containing a dose of the formulation (2), with an end piece or mouthpiece (8) for dispensing the formulation (2), in particular as an aerosol, with a cover (10) belonging to the end piece or mouthpiece (8) and manually movable for opening and / or closing (10) , and with a transport device (23) for preferably stepwise advancing the reservoir (3), so that the containers (4) can be emptied one after the other, characterized in that the atomizer (1) is designed such that by opening the Cover (10) the transport device (23) is actuated, whereby the reservoir (3) to a container (4) is moved forward. 2. Atomiser according to claim 1, characterized in that the atomizer (1) has a gear or a transmission (15), so that from the opening and / or closing movement of the cover (10) has a preferably axial movement for opening the next container (4), for moving and / or advancing the reservoir (3), for tensioning a spring accumulator, for actuating a dispensing device (5), in particular for sucking air, and / or for actuating a counting device (59) are generated. 3. Atomizer according to claim 2, characterized in that the translation or the transmission (15) has different gear ratios on the output side for driving various devices. 4. atomizer according to claim 2 or 3, characterized in that the translation or the transmission (15) has a thread, in particular a rotatable threaded sleeve (16), which particularly preferably has an inner and / or outer thread (17,18), wherein preferably the thread or the threaded sleeve (16) is coupled directly or indirectly to the cover (10) and / or coaxially with a pivot axis (12) of the cover (10) is arranged or forms. 5. Atomiser according to one of claims 2 to 4, characterized in that the translation or the transmission (15) is arranged in the interior of an annular arrangement of the reservoir (3) or the containers (4). 6. Atomiser according to one of claims 2 to 5, characterized in that the translation or the transmission (15) has at least one sliding guide (70, 75) and in particular a control element (68) which forms the sliding guide (70, 75) and preferably by means of the cover (10) is rotatable. 7. Atomiser according to one of claims 2 and 6, characterized in that the transport device (23) by means of the cover (10) via the transmission or the transmission (15) is driven. 8. Atomiser according to one of the preceding claims, characterized in that the reservoir (3) has a toothing, in which the transport device (23) engages, so that the reservoir (3) for advancing the containers (4) is moved or rotated. 9. Atomizer according to one of the preceding claims, characterized in that the reservoir (3) is designed as a rigid ring. 39/73 isteTOdiiscises föfeütawi AT13 748U1 2014-08-15 10. Atomiser according to one of the preceding claims, characterized in that the atomizer (1) is designed such that by opening the cover (10) a connecting device (24) is actuated, so that the next container (4) with the dispensing device ( 5) is connected to atomize the respective dose and / or the container (4) is opened, in particular the container (4) is pierced. 11. Atomiser according to one of the preceding claims, characterized in that the atomizer (1) is designed such that the cover (10) transversely to the direction of delivery (11) of the end or mouthpiece (8) movable, in particular slidable and / or pivotable, and / or that the cover (10) is movable tangentially to a housing (13) or along a circumference of the atomizer (1). 12. Atomizer according to one of the preceding claims, characterized in that the cover (10) extends substantially around the circumference, in particular along a peripheral portion of the atomizer (1). 13. An atomiser according to one of the preceding claims, characterized in that the atomizer (1) is designed such that a discharge medium, such as air, for the delivery of the formulation (2) can be pressurized. 14. Atomizer according to one of the preceding claims, characterized in that the atomizer (1) is flat, in particular disk-shaped, is formed. 15. Atomizer according to one of the preceding claims, characterized in that the atomizer (1) is designed as a preferably portable inhaler, particularly preferably as a powder inhaler, in particular for medical aerosol therapy. For this 33 sheets drawings 40/73