AR241494A1 - {bis(hydroxymethyl)-methyl]-isoquinoline derivatives, process for preparing them and pharmaceutical compositions containing them - Google Patents
{bis(hydroxymethyl)-methyl]-isoquinoline derivatives, process for preparing them and pharmaceutical compositions containing themInfo
- Publication number
- AR241494A1 AR241494A1 AR30989088A AR30989088A AR241494A1 AR 241494 A1 AR241494 A1 AR 241494A1 AR 30989088 A AR30989088 A AR 30989088A AR 30989088 A AR30989088 A AR 30989088A AR 241494 A1 AR241494 A1 AR 241494A1
- Authority
- AR
- Argentina
- Prior art keywords
- bis
- preparing
- isoquinoline derivatives
- hydroxymethyl
- methyl
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR DERIVADOS DE ISOQUINOLINA DE ACCION ANTIPIRETICA Y ANALGESICA DE FORMULA (I), DONDE R1 Y R2 SON ALCOXI, Y R7 ES BENZOILO, 3,4-DIALCOXI -BENZOILO Y 3,4,5-TRIALCOXI -BENZOILO, HACIENDO REACCIONAR UNA 1-¡BIS(HIDROXIMETIL)-METIL¿-6,7-DIALCOXI -1,2,3,4- TETRAHIDROISOQUINOLINA FORMULA SIMILAR O LA (I), EN DONDE LOS DOS OXIGENOS ESTAN UNIDOS A HIDROGENOS, CON UN HALURO DE BENZOILO DE FORMULA X - R7, X ES HALOGENO Y R7 TIENE LOS VALORES YA DADOS, OBTENIENDO UN COMPUESTO INTERMEDIO DONDE R7 SE ENLAZA EN EL N DEL HETEROCICLO SUSTITUYENDO AL HIDROGENO, QUE POR CALENTAMIENTO EN MEDIO ACIDO SE TRANSFORMA, EN EL COMPUESTO DE FORMULA (I), O SU SAL.PROCEDURE FOR PREPARING ANTIPIRETIC AND ANALGESICAL ACTION ISOQUINOLINE DERIVATIVES OF FORMULA (I), WHERE R1 AND R2 ARE ALCOXY, AND R7 IS BENZOYL, 3,4-DIALCOXI-BENZOYL AND UNAZYL, HACIENZYL, 1-BIS (HYDROXIMETIL) -METIL¿-6,7-DIALCOXI -1,2,3,4- TETRAHIDROISOQUINOLINA SIMILAR FORMULA OR (I), WHERE THE TWO OXYGEN ARE ATTACHED TO HYDROGENS, WITH A BENZOYL HALIDE FORMULA X - R7, X IS HALOGEN AND R7 HAS THE VALUES ALREADY GIVEN, OBTAINING AN INTERMEDIATE COMPOUND WHERE R7 IS LINKED IN THE N OF THE HETEROCICLE SUBSTITUTING THE HYDROGEN, WHICH IS TRANSFORMED IN THE COMPU , OR HIS SALT.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU833655A HU186810B (en) | 1983-10-25 | 1983-10-25 | Process for producing 2h-azeto/2,1-a/ isoquinoline-derivatives |
HU833652A HU189765B (en) | 1983-10-25 | 1983-10-25 | Process for preparing n-substituted 1-(bis (hydroxy-metiol)-methyl)-isoquinoline-derivatives |
HU833654A HU190458B (en) | 1983-10-25 | 1983-10-25 | Process for preparing /1,3/ oxazino /4,3-a/ isoquinoline-derivatives |
HU833653A HU189764B (en) | 1983-10-25 | 1983-10-25 | Process for preparing 1-(bis (substituted methyl)-methyl)-isoquinoline-derivatives |
HU833651A HU189348B (en) | 1983-10-25 | 1983-10-25 | Process for producing l-/bis/hydroxy-methyl/-methyl/-3,4-dihydro- or 1,2,3,4-tetrahydro-isoquinolin derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
AR241494A1 true AR241494A1 (en) | 1992-07-31 |
Family
ID=32873013
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AR29837684A AR241490A1 (en) | 1983-10-25 | 1984-10-25 | {bis(hydroxymethyl)-methyl]-isoquinoline derivatives, process for preparing them and pharmaceutical compositions containing them |
AR30989288A AR241496A1 (en) | 1983-10-25 | 1988-01-22 | {bis(hydroxymethyl)-methyl]-isoquinoline derivatives, process for preparing them and pharmaceutical compositions containing them |
AR30989188A AR241497A1 (en) | 1983-10-25 | 1988-01-22 | {bis(hydroxymethyl)-methyl]-isoquinoline derivatives, process for preparing them and pharmaceutical compositions containing them |
AR30989088A AR241494A1 (en) | 1983-10-25 | 1988-01-22 | {bis(hydroxymethyl)-methyl]-isoquinoline derivatives, process for preparing them and pharmaceutical compositions containing them |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AR29837684A AR241490A1 (en) | 1983-10-25 | 1984-10-25 | {bis(hydroxymethyl)-methyl]-isoquinoline derivatives, process for preparing them and pharmaceutical compositions containing them |
AR30989288A AR241496A1 (en) | 1983-10-25 | 1988-01-22 | {bis(hydroxymethyl)-methyl]-isoquinoline derivatives, process for preparing them and pharmaceutical compositions containing them |
AR30989188A AR241497A1 (en) | 1983-10-25 | 1988-01-22 | {bis(hydroxymethyl)-methyl]-isoquinoline derivatives, process for preparing them and pharmaceutical compositions containing them |
Country Status (1)
Country | Link |
---|---|
AR (4) | AR241490A1 (en) |
-
1984
- 1984-10-25 AR AR29837684A patent/AR241490A1/en active
-
1988
- 1988-01-22 AR AR30989288A patent/AR241496A1/en active
- 1988-01-22 AR AR30989188A patent/AR241497A1/en active
- 1988-01-22 AR AR30989088A patent/AR241494A1/en active
Also Published As
Publication number | Publication date |
---|---|
AR241496A1 (en) | 1992-07-31 |
AR241490A1 (en) | 1992-07-31 |
AR241497A1 (en) | 1992-07-31 |
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