AR241494A1 - {bis(hydroxymethyl)-methyl]-isoquinoline derivatives, process for preparing them and pharmaceutical compositions containing them - Google Patents

{bis(hydroxymethyl)-methyl]-isoquinoline derivatives, process for preparing them and pharmaceutical compositions containing them

Info

Publication number
AR241494A1
AR241494A1 AR30989088A AR30989088A AR241494A1 AR 241494 A1 AR241494 A1 AR 241494A1 AR 30989088 A AR30989088 A AR 30989088A AR 30989088 A AR30989088 A AR 30989088A AR 241494 A1 AR241494 A1 AR 241494A1
Authority
AR
Argentina
Prior art keywords
bis
preparing
isoquinoline derivatives
hydroxymethyl
methyl
Prior art date
Application number
AR30989088A
Other languages
Spanish (es)
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU833655A external-priority patent/HU186810B/en
Priority claimed from HU833652A external-priority patent/HU189765B/en
Priority claimed from HU833654A external-priority patent/HU190458B/en
Priority claimed from HU833653A external-priority patent/HU189764B/en
Priority claimed from HU833651A external-priority patent/HU189348B/en
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Application granted granted Critical
Publication of AR241494A1 publication Critical patent/AR241494A1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE ISOQUINOLINA DE ACCION ANTIPIRETICA Y ANALGESICA DE FORMULA (I), DONDE R1 Y R2 SON ALCOXI, Y R7 ES BENZOILO, 3,4-DIALCOXI -BENZOILO Y 3,4,5-TRIALCOXI -BENZOILO, HACIENDO REACCIONAR UNA 1-¡BIS(HIDROXIMETIL)-METIL¿-6,7-DIALCOXI -1,2,3,4- TETRAHIDROISOQUINOLINA FORMULA SIMILAR O LA (I), EN DONDE LOS DOS OXIGENOS ESTAN UNIDOS A HIDROGENOS, CON UN HALURO DE BENZOILO DE FORMULA X - R7, X ES HALOGENO Y R7 TIENE LOS VALORES YA DADOS, OBTENIENDO UN COMPUESTO INTERMEDIO DONDE R7 SE ENLAZA EN EL N DEL HETEROCICLO SUSTITUYENDO AL HIDROGENO, QUE POR CALENTAMIENTO EN MEDIO ACIDO SE TRANSFORMA, EN EL COMPUESTO DE FORMULA (I), O SU SAL.PROCEDURE FOR PREPARING ANTIPIRETIC AND ANALGESICAL ACTION ISOQUINOLINE DERIVATIVES OF FORMULA (I), WHERE R1 AND R2 ARE ALCOXY, AND R7 IS BENZOYL, 3,4-DIALCOXI-BENZOYL AND UNAZYL, HACIENZYL, 1-BIS (HYDROXIMETIL) -METIL¿-6,7-DIALCOXI -1,2,3,4- TETRAHIDROISOQUINOLINA SIMILAR FORMULA OR (I), WHERE THE TWO OXYGEN ARE ATTACHED TO HYDROGENS, WITH A BENZOYL HALIDE FORMULA X - R7, X IS HALOGEN AND R7 HAS THE VALUES ALREADY GIVEN, OBTAINING AN INTERMEDIATE COMPOUND WHERE R7 IS LINKED IN THE N OF THE HETEROCICLE SUBSTITUTING THE HYDROGEN, WHICH IS TRANSFORMED IN THE COMPU , OR HIS SALT.

AR30989088A 1983-10-25 1988-01-22 {bis(hydroxymethyl)-methyl]-isoquinoline derivatives, process for preparing them and pharmaceutical compositions containing them AR241494A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
HU833655A HU186810B (en) 1983-10-25 1983-10-25 Process for producing 2h-azeto/2,1-a/ isoquinoline-derivatives
HU833652A HU189765B (en) 1983-10-25 1983-10-25 Process for preparing n-substituted 1-(bis (hydroxy-metiol)-methyl)-isoquinoline-derivatives
HU833654A HU190458B (en) 1983-10-25 1983-10-25 Process for preparing /1,3/ oxazino /4,3-a/ isoquinoline-derivatives
HU833653A HU189764B (en) 1983-10-25 1983-10-25 Process for preparing 1-(bis (substituted methyl)-methyl)-isoquinoline-derivatives
HU833651A HU189348B (en) 1983-10-25 1983-10-25 Process for producing l-/bis/hydroxy-methyl/-methyl/-3,4-dihydro- or 1,2,3,4-tetrahydro-isoquinolin derivatives

Publications (1)

Publication Number Publication Date
AR241494A1 true AR241494A1 (en) 1992-07-31

Family

ID=32873013

Family Applications (4)

Application Number Title Priority Date Filing Date
AR29837684A AR241490A1 (en) 1983-10-25 1984-10-25 {bis(hydroxymethyl)-methyl]-isoquinoline derivatives, process for preparing them and pharmaceutical compositions containing them
AR30989288A AR241496A1 (en) 1983-10-25 1988-01-22 {bis(hydroxymethyl)-methyl]-isoquinoline derivatives, process for preparing them and pharmaceutical compositions containing them
AR30989188A AR241497A1 (en) 1983-10-25 1988-01-22 {bis(hydroxymethyl)-methyl]-isoquinoline derivatives, process for preparing them and pharmaceutical compositions containing them
AR30989088A AR241494A1 (en) 1983-10-25 1988-01-22 {bis(hydroxymethyl)-methyl]-isoquinoline derivatives, process for preparing them and pharmaceutical compositions containing them

Family Applications Before (3)

Application Number Title Priority Date Filing Date
AR29837684A AR241490A1 (en) 1983-10-25 1984-10-25 {bis(hydroxymethyl)-methyl]-isoquinoline derivatives, process for preparing them and pharmaceutical compositions containing them
AR30989288A AR241496A1 (en) 1983-10-25 1988-01-22 {bis(hydroxymethyl)-methyl]-isoquinoline derivatives, process for preparing them and pharmaceutical compositions containing them
AR30989188A AR241497A1 (en) 1983-10-25 1988-01-22 {bis(hydroxymethyl)-methyl]-isoquinoline derivatives, process for preparing them and pharmaceutical compositions containing them

Country Status (1)

Country Link
AR (4) AR241490A1 (en)

Also Published As

Publication number Publication date
AR241496A1 (en) 1992-07-31
AR241490A1 (en) 1992-07-31
AR241497A1 (en) 1992-07-31

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