AR225663A1 - Un proceso para la preparacion de vincristina por oxidacion de vlb - Google Patents
Un proceso para la preparacion de vincristina por oxidacion de vlbInfo
- Publication number
- AR225663A1 AR225663A1 AR284784A AR28478481A AR225663A1 AR 225663 A1 AR225663 A1 AR 225663A1 AR 284784 A AR284784 A AR 284784A AR 28478481 A AR28478481 A AR 28478481A AR 225663 A1 AR225663 A1 AR 225663A1
- Authority
- AR
- Argentina
- Prior art keywords
- vlb
- vincristine
- oxidation
- preparation
- vlb oxidation
- Prior art date
Links
- 238000000034 method Methods 0.000 title 1
- 230000003647 oxidation Effects 0.000 title 1
- 238000007254 oxidation reaction Methods 0.000 title 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 title 1
- 229960004528 vincristine Drugs 0.000 title 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/136,616 US4303584A (en) | 1980-04-02 | 1980-04-02 | Method of preparing vincristine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR225663A1 true AR225663A1 (es) | 1982-04-15 |
Family
ID=22473604
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR284784A AR225663A1 (es) | 1980-04-02 | 1981-03-30 | Un proceso para la preparacion de vincristina por oxidacion de vlb |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4303584A (cs) |
| EP (1) | EP0037289B1 (cs) |
| JP (1) | JPS56154487A (cs) |
| KR (1) | KR840000706B1 (cs) |
| AR (1) | AR225663A1 (cs) |
| CA (1) | CA1171411A (cs) |
| CS (1) | CS227481A2 (cs) |
| DE (1) | DE3165176D1 (cs) |
| GB (1) | GB2073196B (cs) |
| HU (1) | HU183384B (cs) |
| IE (1) | IE51081B1 (cs) |
| IL (1) | IL62513A (cs) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU84640A1 (fr) * | 1983-02-10 | 1984-11-08 | Onmichem S A | Nouveau procede d'obtention de la vincristine et du sulfate de vincristine |
| HU190219B (en) * | 1984-01-06 | 1986-08-28 | Richter Gedeon Vegyeszeti Gyar Rt,Hu | Process for preparing in 3",7'-position cyclized dimer-cinca-alkaloid-derivatives |
| EP1989212B1 (en) * | 2006-02-17 | 2013-06-19 | Cascade Prodrug Inc. | Treatment of hyperproliferative diseases with vinca alkaloid n-oxide and analogs |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3354163A (en) * | 1966-12-15 | 1967-11-21 | Eli Lillty And Company | Nu-desmethylvinblastine |
| US3899493A (en) * | 1972-12-29 | 1975-08-12 | Richter Gedeon Vegyeszet | Chromic acid oxidation of vinblastine sulfate to form vincristine |
| HU168433B (cs) * | 1973-12-20 | 1976-04-28 | ||
| HU178706B (en) * | 1979-04-23 | 1982-06-28 | Richter Gedeon Vegyeszet | Process for preparing bis-indole alkaloids and acid addition salts thereof |
-
1980
- 1980-04-02 US US06/136,616 patent/US4303584A/en not_active Expired - Lifetime
-
1981
- 1981-03-27 CS CS812274A patent/CS227481A2/cs unknown
- 1981-03-29 IL IL62513A patent/IL62513A/xx not_active IP Right Cessation
- 1981-03-30 AR AR284784A patent/AR225663A1/es active
- 1981-03-30 CA CA000374169A patent/CA1171411A/en not_active Expired
- 1981-04-01 IE IE746/81A patent/IE51081B1/en not_active IP Right Cessation
- 1981-04-01 JP JP5002381A patent/JPS56154487A/ja active Granted
- 1981-04-01 HU HU81847A patent/HU183384B/hu unknown
- 1981-04-01 KR KR1019810001095A patent/KR840000706B1/ko not_active Expired
- 1981-04-02 DE DE8181301437T patent/DE3165176D1/de not_active Expired
- 1981-04-02 GB GB8110428A patent/GB2073196B/en not_active Expired
- 1981-04-02 EP EP81301437A patent/EP0037289B1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| EP0037289A1 (en) | 1981-10-07 |
| JPS56154487A (en) | 1981-11-30 |
| IE51081B1 (en) | 1986-10-01 |
| KR840000706B1 (ko) | 1984-05-21 |
| HU183384B (en) | 1984-04-28 |
| IE810746L (en) | 1981-10-02 |
| GB2073196A (en) | 1981-10-14 |
| IL62513A0 (en) | 1981-05-20 |
| IL62513A (en) | 1984-01-31 |
| EP0037289B1 (en) | 1984-08-01 |
| JPH0125755B2 (cs) | 1989-05-19 |
| DE3165176D1 (en) | 1984-09-06 |
| CA1171411A (en) | 1984-07-24 |
| KR830005211A (ko) | 1983-08-03 |
| GB2073196B (en) | 1984-01-25 |
| CS227481A2 (en) | 1985-06-13 |
| US4303584A (en) | 1981-12-01 |
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