AR127419A1 - Transdiferenciación de células de la papila no-dérmica a células de la papila dérmica - Google Patents
Transdiferenciación de células de la papila no-dérmica a células de la papila dérmicaInfo
- Publication number
- AR127419A1 AR127419A1 ARP220102859A ARP220102859A AR127419A1 AR 127419 A1 AR127419 A1 AR 127419A1 AR P220102859 A ARP220102859 A AR P220102859A AR P220102859 A ARP220102859 A AR P220102859A AR 127419 A1 AR127419 A1 AR 127419A1
- Authority
- AR
- Argentina
- Prior art keywords
- dermal papilla
- cells
- papilla cells
- alopecia
- transdifferentiation
- Prior art date
Links
- 230000002500 effect on skin Effects 0.000 title abstract 7
- 210000004027 cell Anatomy 0.000 abstract 6
- 201000004384 Alopecia Diseases 0.000 abstract 5
- 101000909637 Homo sapiens Transcription factor COE1 Proteins 0.000 abstract 2
- 102100024207 Transcription factor COE1 Human genes 0.000 abstract 2
- 208000024963 hair loss Diseases 0.000 abstract 2
- 230000003676 hair loss Effects 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 230000008672 reprogramming Effects 0.000 abstract 2
- 102100025683 Alkaline phosphatase, tissue-nonspecific isozyme Human genes 0.000 abstract 1
- 208000003024 Diffuse alopecia Diseases 0.000 abstract 1
- 102100039563 ETS translocation variant 1 Human genes 0.000 abstract 1
- 101150043847 FOXD1 gene Proteins 0.000 abstract 1
- 102100028071 Fibroblast growth factor 7 Human genes 0.000 abstract 1
- 102100037057 Forkhead box protein D1 Human genes 0.000 abstract 1
- 102100038353 Gremlin-2 Human genes 0.000 abstract 1
- 101000574445 Homo sapiens Alkaline phosphatase, tissue-nonspecific isozyme Proteins 0.000 abstract 1
- 101000813729 Homo sapiens ETS translocation variant 1 Proteins 0.000 abstract 1
- 101001060261 Homo sapiens Fibroblast growth factor 7 Proteins 0.000 abstract 1
- 101001032861 Homo sapiens Gremlin-2 Proteins 0.000 abstract 1
- 101001035232 Homo sapiens Integrin alpha-9 Proteins 0.000 abstract 1
- 101001069727 Homo sapiens Paired mesoderm homeobox protein 1 Proteins 0.000 abstract 1
- 101001126417 Homo sapiens Platelet-derived growth factor receptor alpha Proteins 0.000 abstract 1
- 101000821885 Homo sapiens Protein S100-B Proteins 0.000 abstract 1
- 101000825962 Homo sapiens R-spondin-4 Proteins 0.000 abstract 1
- 101000653635 Homo sapiens T-box transcription factor TBX18 Proteins 0.000 abstract 1
- 101000652326 Homo sapiens Transcription factor SOX-18 Proteins 0.000 abstract 1
- 101000857270 Homo sapiens Zinc finger protein GLIS1 Proteins 0.000 abstract 1
- 102100039903 Integrin alpha-9 Human genes 0.000 abstract 1
- 102100024894 PR domain zinc finger protein 1 Human genes 0.000 abstract 1
- 102100033786 Paired mesoderm homeobox protein 1 Human genes 0.000 abstract 1
- 102100030485 Platelet-derived growth factor receptor alpha Human genes 0.000 abstract 1
- 108010009975 Positive Regulatory Domain I-Binding Factor 1 Proteins 0.000 abstract 1
- 102100021487 Protein S100-B Human genes 0.000 abstract 1
- 102100022759 R-spondin-4 Human genes 0.000 abstract 1
- 102100029848 T-box transcription factor TBX18 Human genes 0.000 abstract 1
- 206010043866 Tinea capitis Diseases 0.000 abstract 1
- 102100030249 Transcription factor SOX-18 Human genes 0.000 abstract 1
- 108010083176 Twist-Related Protein 2 Proteins 0.000 abstract 1
- 102100031720 Twist-related protein 2 Human genes 0.000 abstract 1
- 102100025883 Zinc finger protein GLIS1 Human genes 0.000 abstract 1
- 231100000360 alopecia Toxicity 0.000 abstract 1
- 208000004631 alopecia areata Diseases 0.000 abstract 1
- 201000002996 androgenic alopecia Diseases 0.000 abstract 1
- 210000003317 double-positive, alpha-beta immature T lymphocyte Anatomy 0.000 abstract 1
- ONCZDRURRATYFI-QTCHDTBASA-N methyl (2z)-2-methoxyimino-2-[2-[[(e)-1-[3-(trifluoromethyl)phenyl]ethylideneamino]oxymethyl]phenyl]acetate Chemical compound CO\N=C(/C(=O)OC)C1=CC=CC=C1CO\N=C(/C)C1=CC=CC(C(F)(F)F)=C1 ONCZDRURRATYFI-QTCHDTBASA-N 0.000 abstract 1
- 201000001297 telogen effluvium Diseases 0.000 abstract 1
- 208000002271 trichotillomania Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/09—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from epidermal cells, from skin cells, from oral mucosa cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Dermatology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Cosmetics (AREA)
Abstract
Se proporcionan composiciones de un sistema y los métodos para su uso a fin de transdiferenciar células de la papila no-dérmica (DP) en células inducidas de la papila dérmica (iDPC) y utilizarlas posteriormente en el tratamiento de la pérdida del cabello. Reivindicación 1: Una composición que comprende: una población de células de la papila no dérmica; una población de células inducidas de la papila dérmica (iDPC) que expresan uno o más marcadores seleccionados del grupo formado por ALPL, EBF1, ETV1, FGF7, FOXD1, GLIS1, GREM2, ITGA9, PDGFRA, PRDM1, PRRX1, RSPO4, S100B, SOX18, TBX18 y TWIST2; y un sistema de reprogramación de células de la papila dérmica (DPCR) que comprende uno o más factores de reprogramación de células de la papila dérmica seleccionados del grupo formado por un agente EBF o un agente TWIST, donde el sistema DPCR causa la transdiferenciación de una o más células no-DP en una o más iDPC. Reivindicación 62: El método de acuerdo con la reivindicación 61, caracterizado porque la condición de pérdida de cabello se selecciona de entre: alopecia androgénica, alopecia areata, efluvio telógeno, tricotilomanía, alopecia por tracción, tiña de la cabeza, alopecia cicatricial, ardor o cicatrización.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163257752P | 2021-10-20 | 2021-10-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR127419A1 true AR127419A1 (es) | 2024-01-24 |
Family
ID=84359666
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP220102859A AR127419A1 (es) | 2021-10-20 | 2022-10-20 | Transdiferenciación de células de la papila no-dérmica a células de la papila dérmica |
Country Status (2)
| Country | Link |
|---|---|
| AR (1) | AR127419A1 (es) |
| WO (1) | WO2023070026A1 (es) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7229961B2 (en) | 1999-08-24 | 2007-06-12 | Cellgate, Inc. | Compositions and methods for enhancing drug delivery across and into ocular tissues |
| US6593292B1 (en) | 1999-08-24 | 2003-07-15 | Cellgate, Inc. | Compositions and methods for enhancing drug delivery across and into epithelial tissues |
| US7256286B2 (en) | 1999-11-30 | 2007-08-14 | The Board Of Trustees Of The Leland Stanford Junior University | Bryostatin analogues, synthetic methods and uses |
| EP1305333A4 (en) | 2000-07-31 | 2006-04-12 | Active Motif | ADMINISTRATION OF MOLECULES IN CELLS BY PEPTIDE MEDIATION |
| US7585834B2 (en) | 2001-02-16 | 2009-09-08 | The Board Of Trustees Of The Leland Stanford Junior University | Transporters comprising spaced arginine moieties |
| WO2006124356A2 (en) * | 2005-05-16 | 2006-11-23 | The Rockefeller University | Method for isolating dermal papilla cells and uses thereof |
| SG10202111888XA (en) * | 2014-07-09 | 2021-11-29 | Sanford Burnham Med Res Inst | Methods and compositions to modulate hair growth |
| US11629331B2 (en) * | 2017-07-19 | 2023-04-18 | Seoul National University R & Db Foundation | Method of differentiation of human induced pluripotent stem cell to dermal papilla precursor cell and use thereof |
-
2022
- 2022-10-20 AR ARP220102859A patent/AR127419A1/es unknown
- 2022-10-20 WO PCT/US2022/078422 patent/WO2023070026A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2023070026A1 (en) | 2023-04-27 |
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