AR126364A2 - ANTI-CD3 ANTIBODIES AND METHODS OF USE - Google Patents
ANTI-CD3 ANTIBODIES AND METHODS OF USEInfo
- Publication number
- AR126364A2 AR126364A2 ARP220101736A ARP220101736A AR126364A2 AR 126364 A2 AR126364 A2 AR 126364A2 AR P220101736 A ARP220101736 A AR P220101736A AR P220101736 A ARP220101736 A AR P220101736A AR 126364 A2 AR126364 A2 AR 126364A2
- Authority
- AR
- Argentina
- Prior art keywords
- rhv
- seq
- amino acid
- acid sequence
- antibody
- Prior art date
Links
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 5
- 230000004069 differentiation Effects 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La invención proporciona los anticuerpos 3 (CD3) de los anti-cúmulos de diferenciación y los métodos para utilizarlos. Reivindicación 1: Un antigrupo de 3 anticuerpos (CD3) de diferenciación, donde el anticuerpo anti-CD3 comprende un dominio de unión que consta de las siguientes seis regiones hipervariables (RHV): (a) una RHV-H1 que consiste en una secuencia de aminoácidos con SEQ ID Nº 1; (b) una RHV-H2 que consiste en una secuencia de aminoácidos con SEQ ID Nº 2; (c) una RHV-H3 que consiste en una secuencia de aminoácidos con SEQ ID Nº 3; (d) una RHV-L1 que consiste en una secuencia de aminoácidos con SEQ ID Nº 4; (e) una RHV-L2 que consiste en una secuencia de aminoácidos con SEQ ID Nº 5; y (f) una RHV-L3 que consiste en una secuencia de aminoácidos con SEQ ID Nº 6. Reivindicación 277: Un ácido nucleico aislado que codifica el anticuerpo anti-CD3 de cualquiera de los reclamos 1 - 276. Reivindicación 278: Un vector que consta del ácido nucleico aislado del reclamo 277. Reivindicación 279: Una célula anfitriona que consta del vector del reclamo 278.The invention provides anti-cluster of differentiation 3 (CD3) antibodies and methods for using them. Claim 1: An anti-cluster 3 (CD3) differentiation antibody, wherein the anti-CD3 antibody comprises a binding domain consisting of the following six hypervariable regions (RHV): (a) an RHV-H1 consisting of a sequence of amino acids with SEQ ID NO: 1; (b) a RHV-H2 consisting of an amino acid sequence with SEQ ID NO: 2; (c) a RHV-H3 consisting of an amino acid sequence with SEQ ID NO: 3; (d) a RHV-L1 consisting of an amino acid sequence with SEQ ID NO: 4; (e) a RHV-L2 consisting of an amino acid sequence with SEQ ID NO: 5; and (f) an RHV-L3 consisting of an amino acid sequence with SEQ ID NO: 6. Claim 277: An isolated nucleic acid encoding the anti-CD3 antibody of any of claims 1 - 276. Claim 278: A vector that consists of the isolated nucleic acid of claim 277. Claim 279: A host cell consisting of the vector of claim 278.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361917346P | 2013-12-17 | 2013-12-17 | |
| US202061949950P | 2020-03-07 | 2020-03-07 | |
| US202062026594P | 2020-07-18 | 2020-07-18 | |
| US202062053582P | 2020-09-22 | 2020-09-22 | |
| US202062091441P | 2020-12-12 | 2020-12-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR126364A2 true AR126364A2 (en) | 2023-10-11 |
Family
ID=88197406
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP220101412A AR126039A2 (en) | 2013-12-17 | 2022-05-27 | ANTI-CD3 ANTIBODIES AND METHODS OF USE |
| ARP220101736A AR126364A2 (en) | 2013-12-17 | 2022-07-01 | ANTI-CD3 ANTIBODIES AND METHODS OF USE |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP220101412A AR126039A2 (en) | 2013-12-17 | 2022-05-27 | ANTI-CD3 ANTIBODIES AND METHODS OF USE |
Country Status (1)
| Country | Link |
|---|---|
| AR (2) | AR126039A2 (en) |
-
2022
- 2022-05-27 AR ARP220101412A patent/AR126039A2/en unknown
- 2022-07-01 AR ARP220101736A patent/AR126364A2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR126039A2 (en) | 2023-09-06 |
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