AR126147A1 - UREA DERIVATIVES TO TREAT CANCER - Google Patents
UREA DERIVATIVES TO TREAT CANCERInfo
- Publication number
- AR126147A1 AR126147A1 ARP220101569A ARP220101569A AR126147A1 AR 126147 A1 AR126147 A1 AR 126147A1 AR P220101569 A ARP220101569 A AR P220101569A AR P220101569 A ARP220101569 A AR P220101569A AR 126147 A1 AR126147 A1 AR 126147A1
- Authority
- AR
- Argentina
- Prior art keywords
- pi3ka
- disorder
- disease
- condition
- treat cancer
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Esta descripción proporciona y reivindica compuestos de fórmula (1), como se definen en la reivindicación 1, en donde Z es O o NRˣ; y el Anillo A es un arilo de 6 - 10 miembros, un cicloalquilo C₃-C₈, un heteroarilo de 5 - 10 miembros o un heterociclilo de 4 - 10 miembros; y sales farmacéuticamente aceptables de estos, que inhiben la isoforma a (PI3Ka) de la fosfatidilinositol 4,5-bisfosfato 3-quinasa (PI3K). Estas entidades químicas son útiles, por ejemplo, para tratar una afección, enfermedad o trastorno en el que el aumento (por ejemplo, excesivo) de la activación de PI3Ka contribuye a la patología y/o a los síntomas y/o a la progresión de la afección, enfermedad o trastorno (por ejemplo, cáncer) en un sujeto (por ejemplo, un ser humano). Esta descripción también proporciona composiciones que contienen la misma, así como también métodos de uso y fabricación de la misma.This description provides and claims compounds of formula (1), as defined in claim 1, wherein Z is O or NRˣ; and Ring A is a 6-10 membered aryl, a C₃-C₈ cycloalkyl, a 5-10 membered heteroaryl or a 4-10 membered heterocyclyl; and pharmaceutically acceptable salts thereof, which inhibit the a (PI3Ka) isoform of phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K). These chemical entities are useful, for example, for treating a condition, disease or disorder in which increased (e.g., excessive) PI3Ka activation contributes to the pathology and/or symptoms and/or progression of the condition. , disease or disorder (for example, cancer) in a subject (for example, a human being). This description also provides compositions containing the same, as well as methods of use and manufacture thereof.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063316017P | 2020-03-03 | 2020-03-03 | |
| US202063319236P | 2020-03-11 | 2020-03-11 | |
| US202063348261P | 2020-06-02 | 2020-06-02 | |
| US202063228351P | 2020-08-02 | 2020-08-02 | |
| US202063288909P | 2020-12-13 | 2020-12-13 | |
| US202163210370P | 2021-06-14 | 2021-06-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR126147A1 true AR126147A1 (en) | 2023-09-13 |
Family
ID=88197371
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP220101569A AR126147A1 (en) | 2020-03-03 | 2022-06-14 | UREA DERIVATIVES TO TREAT CANCER |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR126147A1 (en) |
-
2022
- 2022-06-14 AR ARP220101569A patent/AR126147A1/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CL2023003691A1 (en) | Urea derivatives that can be used to treat cancer | |
| ECSP22087539A (en) | FUSIONED TRICYCLIC KRAS INHIBITORS | |
| DOP2022000266A (en) | 2-AMINO-3-CYANOTHIOPHENES ANNULLED AND DERIVATIVES FOR THE TREATMENT OF CANCER | |
| CO2023008167A2 (en) | prmt5 inhibitors | |
| UY28990A1 (en) | NEW DERIVATIVES OF BENZENE 1, 3-CARBON AMINO AS B-RAF INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, PREPARATION AND USE PROCESSES. | |
| GT200900056A (en) | BENZOXAZOLES AND USEFUL OXAZOLOPIRIDINS AS INHIBITORS OF THE QUANASA JANUS | |
| DOP2024000019A (en) | COMPOUNDS THAT INHIBIT THE ALPHA ISOFORM OF PI3K AND METHODS FOR TREATING CANCER | |
| UY28059A1 (en) | NEW DERIVATIVES OF DIHYDROPIRIMIDO (4,5-D) PYRIMIDONE REPLACED BY AMINO. MANUFACTURE AND USE OF THE SAME AS PHARMACEUTICAL AGENTS. | |
| HRP20050533A2 (en) | Aminoindazole derivatives and use thereof as kinase inhibitors | |
| NI201000145A (en) | DERIVATIVES OF IMIDAZINE - [1, 2-b] - PYRIDAZINE FOR THE TREATMENT OF DISEASE MEDIATED BY TYROSINE KINASE C-MET. | |
| CL2023000856A1 (en) | Pyrrolo[3,2-c]pyridin-4-one derivatives useful in the treatment of cancer | |
| CO2024001285A2 (en) | Tricyclic compounds as kras inhibitors | |
| DOP2023000218A (en) | PHOSPHORUS DERIVATIVES AS NEW SOS1 INHIBITORS | |
| PE20040930A1 (en) | ARYLVINYLAZACICLOALKANE COMPOUNDS AS BINDERS OF NICOTINE ACETYLCOLINERGIC RECEPTORS (nAChRs) | |
| UY39517A (en) | BTK INHIBITORS | |
| ECSP22098041A (en) | ALLOSTERIC EGFR INHIBITORS AND METHODS OF USE OF THESE | |
| AR126147A1 (en) | UREA DERIVATIVES TO TREAT CANCER | |
| CL2004000226A1 (en) | COMPOUNDS DERIVED FROM [4-AMINO-2 - ((CYCLOALKYL, HETEROCICLE) -AMINO) -PIRIMIDIN-5-IL] - (ARILO, HETEROARILO, CYCLOALQUILO OR HETEROCICLO) METANOMA, QUINASAS CYCLES-ENCULAR-PARKES OF CDYCLES-PARKEN-DE-PARKES ); PREPARATION PROCESS; COMPOUND | |
| UY39819A (en) | METHODS TO TREAT CANCER | |
| DOP2022000203A (en) | 3-PHENOXIAZETIDIN-1-SUBSTITUTED IL-PYRAZINES WITH GPR52 ANTAGONIST ACTIVITY | |
| AR125479A1 (en) | IL4I1 INHIBITORS AND METHODS OF USE | |
| CL2004000631A1 (en) | COMPOUNDS DERIVED FROM ACID 6- (2-BROMOFENIL) -PIRIDO [2,3-DIPIRIMIDIN-7-CARBOXILICO; PHARMACEUTICAL COMPOSITION; PREPARATION PROCEDURE; AND USE TO TREAT CANCER AND TO PREPARE MEDICATIONS TO INHIBIT TUMOR GROWTH. | |
| DOP2024000096A (en) | NAPHTHYRIDINONE DERIVATIVES FOR THE TREATMENT OF A DISEASE OR DISORDER | |
| AR123760A1 (en) | METHODS TO TREAT CANCER | |
| AR123576A1 (en) | METHODS TO TREAT CANCER |