AR124675A2 - 2,2-DIFLUOROPROPANAMIDE AND METHYL BARDOXOLONE DERIVATIVES, POLYMORPHIC FORMS AND METHODS OF USE - Google Patents

2,2-DIFLUOROPROPANAMIDE AND METHYL BARDOXOLONE DERIVATIVES, POLYMORPHIC FORMS AND METHODS OF USE

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Publication number
AR124675A2
AR124675A2 ARP220100100A ARP220100100A AR124675A2 AR 124675 A2 AR124675 A2 AR 124675A2 AR P220100100 A ARP220100100 A AR P220100100A AR P220100100 A ARP220100100 A AR P220100100A AR 124675 A2 AR124675 A2 AR 124675A2
Authority
AR
Argentina
Prior art keywords
difluoropropanamide
methods
polymorphic forms
derivatives
compound
Prior art date
Application number
ARP220100100A
Other languages
Spanish (es)
Inventor
Eric Anderson
Xiaofeng Liu
Andrea Decker
Original Assignee
Reata Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reata Pharmaceuticals Inc filed Critical Reata Pharmaceuticals Inc
Publication of AR124675A2 publication Critical patent/AR124675A2/en

Links

Abstract

La presente invención se relaciona en general con el compuesto: N-((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-ciano-2,2,6a,6b,9,9,12a-heptametil-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahidropiren-4a-il)-2,2-difluoropropanamida, formas polimórficas del mismo, métodos para su preparación y uso, composiciones farmacéuticas del mismo y conjuntos de elementos y artículos para elaborarlo. Reivindicación 1: Un compuesto con la fórmula (1), o una sal farmacéuticamente aceptable del mismo. Reivindicación 44: Un método para tratar o prevenir una condición asociada con la inflamación o estrés oxidativo en un paciente que los necesita, caracterizado porque comprende la administrar a un paciente una cantidad terapéuticamente efectiva del compuesto de acuerdo con las Reivindicaciones 1 a 3, las formas polimórficas de las Reivindicaciones 4 a 24, o la composición farmacéutica de acuerdo con una de las Reivindicaciones 26 a 43.The present invention relates generally to the compound: N-((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl- 10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropyren-4a-yl)-2 ,2-difluoropropanamide, polymorphic forms thereof, methods for its preparation and use, pharmaceutical compositions thereof, and sets of elements and articles for making it. Claim 1: A compound of formula (1), or a pharmaceutically acceptable salt thereof. Claim 44: A method for treating or preventing a condition associated with inflammation or oxidative stress in a patient in need thereof, characterized in that it comprises administering to a patient a therapeutically effective amount of the compound according to Claims 1 to 3, the forms polymorphs of Claims 4 to 24, or the pharmaceutical composition according to one of Claims 26 to 43.

ARP220100100A 2012-04-27 2022-01-18 2,2-DIFLUOROPROPANAMIDE AND METHYL BARDOXOLONE DERIVATIVES, POLYMORPHIC FORMS AND METHODS OF USE AR124675A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261687669P 2012-04-27 2012-04-27

Publications (1)

Publication Number Publication Date
AR124675A2 true AR124675A2 (en) 2023-04-26

Family

ID=75394165

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP220100100A AR124675A2 (en) 2012-04-27 2022-01-18 2,2-DIFLUOROPROPANAMIDE AND METHYL BARDOXOLONE DERIVATIVES, POLYMORPHIC FORMS AND METHODS OF USE

Country Status (2)

Country Link
AR (1) AR124675A2 (en)
HR (1) HRP20210384T1 (en)

Also Published As

Publication number Publication date
HRP20210384T1 (en) 2021-04-16

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