AR123357A1 - COMPOUNDS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS - Google Patents
COMPOUNDS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONSInfo
- Publication number
- AR123357A1 AR123357A1 ARP210102409A ARP210102409A AR123357A1 AR 123357 A1 AR123357 A1 AR 123357A1 AR P210102409 A ARP210102409 A AR P210102409A AR P210102409 A ARP210102409 A AR P210102409A AR 123357 A1 AR123357 A1 AR 123357A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- independently
- compounds
- haloalkyl
- cycloalkyl
- Prior art date
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se describen compuestos y métodos de uso de dichos compuestos, solos o en combinación con agentes adicionales y sales, formas cristalinas, composiciones farmacéuticas de dichos compuestos para el tratamiento de infecciones virales. Reivindicación 1: Un compuesto de fórmula (1) o una sal farmacéuticamente aceptable del mismo, en donde: R¹ es OH, OCOR⁴, o OC(O)OR⁴; R² es OH, OCOR⁵, o OC(O)OR⁵; o R¹ y R² se toman juntos para formar -OC(O)O- o -OCHR⁶O-; en donde R⁶ es H, alquilo C₁-C₆ o arilo C₆-C₁₀; R³ es H, COR⁷ o COOR⁷; R⁴, R⁵, y R⁷ son cada uno independientemente alquilo C₁-C₈, alquenilo C₂-C₈, alquinilo C₂-C₈, carbociclilo C₃-C₈, arilo C₆-C₁₀, o heteroarilo de 5 a 6 miembros que contiene 1, 2 ó 3 heteroátomos seleccionados de N, O, y S; en donde R⁴, R⁵, y R⁷ están cada uno, independientemente, opcionalmente sustituidos con uno, dos o tres sustituyentes independientemente seleccionados del grupo que consta de halógeno, ciano, -N₃, -OR⁸, -NR⁹R¹⁰, y fenilo opcionalmente sustituido con uno, dos o tres sustituyentes independientemente seleccionados de halo, ciano, y alquilo C₁-C₆; y cada R⁸ es independientemente H, alquilo C₁-C₆, haloalquilo C₁-C₆, y cicloalquilo C₃-C₆; cada R⁹ es independientemente H, alquilo C₁-C₆, haloalquilo C₁-C₆, y cicloalquilo C₃-C₆; cada R¹⁰ es independientemente H, alquilo C₁-C₆, haloalquilo C₁-C₆, y cicloalquilo C₃-C₆; y La base es un resto del grupo de fórmulas (2); en donde R¹¹ es alquilo C₁-C₆ sustituido con -OP(O)(OH)₂; siempre que cuando R³ es H luego R¹ es OCOR⁴ o OC(O)OR⁴; o R² es OCOR⁵ o OC(O)OR⁵; o R¹ y R² se toman juntos para formar -OC(O)O- o -OCHR⁶O-. Reivindicación 38: El compuesto de la reivindicación 1, o una sal farmacéuticamente aceptable del mismo, en donde el compuesto es de fórmula (3).Compounds and methods of use of said compounds, alone or in combination with additional agents and salts, crystalline forms, pharmaceutical compositions of said compounds for the treatment of viral infections are described. Claim 1: A compound of formula (1) or a pharmaceutically acceptable salt thereof, wherein: R¹ is OH, OCOR⁴, or OC(O)OR⁴; R² is OH, OCOR⁵, or OC(O)OR⁵; or R¹ and R² are taken together to form -OC(O)O- or -OCHR⁶O-; wherein R⁶ is H, C₁-C₆ alkyl or C₆-C₁₀ aryl; R³ is H, COR⁷ or COOR⁷; R⁴, R⁵, and R⁷ are each independently C₁-C₈ alkyl, C₂-C₈ alkenyl, C₂-C₈ alkynyl, C₃-C₈ carbocyclyl, C₆-C₁₀ aryl, or 5- to 6-membered heteroaryl containing 1, 2, or 3 heteroatoms selected from N, O, and S; wherein R⁴, R⁵, and R⁷ are each, independently, optionally substituted with one, two, or three substituents independently selected from the group consisting of halogen, cyano, -N₃, -OR⁸, -NR⁹R¹⁰, and phenyl optionally substituted with one, two or three substituents independently selected from halo, cyano, and C₁-C₆ alkyl; and each R⁸ is independently H, C₁-C₆ alkyl, C₁-C₆ haloalkyl, and C₃-C₆ cycloalkyl; each R⁹ is independently H, C₁-C₆ alkyl, C₁-C₆ haloalkyl, and C₃-C₆ cycloalkyl; each R¹⁰ is independently H, C₁-C₆ alkyl, C₁-C₆ haloalkyl, and C₃-C₆ cycloalkyl; and The base is a residue from the group of formulas (2); wherein R¹¹ is C₁-C₆ alkyl substituted with -OP(O)(OH)₂; provided that when R³ is H then R¹ is OCOR⁴ or OC(O)OR⁴; or R² is OCOR⁵ or OC(O)OR⁵; or R¹ and R² are taken together to form -OC(O)O- or -OCHR⁶O-. Claim 38: The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein the compound is of formula (3).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063071134P | 2020-08-27 | 2020-08-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR123357A1 true AR123357A1 (en) | 2022-11-23 |
Family
ID=84578072
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP210102409A AR123357A1 (en) | 2020-08-27 | 2021-08-26 | COMPOUNDS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS |
Country Status (1)
Country | Link |
---|---|
AR (1) | AR123357A1 (en) |
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2021
- 2021-08-26 AR ARP210102409A patent/AR123357A1/en unknown
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