AR122456A2 - TETRAHYDRO-PYRIDO[3,4-B]INDOLS MODULATORS OF ESTROGEN RECEPTORS AND THEIR USES - Google Patents
TETRAHYDRO-PYRIDO[3,4-B]INDOLS MODULATORS OF ESTROGEN RECEPTORS AND THEIR USESInfo
- Publication number
- AR122456A2 AR122456A2 ARP210101150A ARP210101150A AR122456A2 AR 122456 A2 AR122456 A2 AR 122456A2 AR P210101150 A ARP210101150 A AR P210101150A AR P210101150 A ARP210101150 A AR P210101150A AR 122456 A2 AR122456 A2 AR 122456A2
- Authority
- AR
- Argentina
- Prior art keywords
- pyrido
- tetrahydro
- modulators
- indols
- estrogen receptors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se describen compuestos tetrahidro-pirido[3,4-b]indol1-ilo con actividad o función de modulación de los receptores de estrógenos modulación, que tienen la estructura de la fórmula (1), y los estereoisómeros, tautómeros o sales farmacéuticamente aceptables de los mismos, con los sustituyentes y características estructurales aquí descritos. Se describen también composiciones farmacéuticas y medicamentos que incluyen los compuestos de la fórmula (1), así como métodos de uso de tales moduladores de receptores de estrógenos, solos o en combinación con otros agentes terapéuticos, para tratar enfermedades o estados patológicos que están mediados o dependen de receptores de estrógenos.Tetrahydro-pyrido[3,4-b]indol1-yl compounds with estrogen receptor modulation activity or function, having the structure of formula (1), and the stereoisomers, tautomers or pharmaceutically acceptable salts of the same, with the substituents and structural characteristics described herein. Pharmaceutical compositions and medicaments including the compounds of formula (1) are also described, as well as methods of using such estrogen receptor modulators, alone or in combination with other therapeutic agents, to treat diseases or pathological conditions that are mediated or They depend on estrogen receptors.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462093929P | 2014-12-18 | 2014-12-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR122456A2 true AR122456A2 (en) | 2022-09-14 |
Family
ID=58672209
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP150104155A AR103081A1 (en) | 2014-12-18 | 2015-12-17 | TETRAHYDRO-PIRIDO [3,4-B] INDULES MODULATORS OF RECEPTORS OF ESTROGENS AND USES OF THE SAME |
ARP210101150A AR122456A2 (en) | 2014-12-18 | 2021-04-28 | TETRAHYDRO-PYRIDO[3,4-B]INDOLS MODULATORS OF ESTROGEN RECEPTORS AND THEIR USES |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP150104155A AR103081A1 (en) | 2014-12-18 | 2015-12-17 | TETRAHYDRO-PIRIDO [3,4-B] INDULES MODULATORS OF RECEPTORS OF ESTROGENS AND USES OF THE SAME |
Country Status (2)
Country | Link |
---|---|
AR (2) | AR103081A1 (en) |
MA (1) | MA41172B1 (en) |
-
2015
- 2015-12-17 MA MA41172A patent/MA41172B1/en unknown
- 2015-12-17 AR ARP150104155A patent/AR103081A1/en unknown
-
2021
- 2021-04-28 AR ARP210101150A patent/AR122456A2/en unknown
Also Published As
Publication number | Publication date |
---|---|
AR103081A1 (en) | 2017-04-12 |
MA41172B1 (en) | 2020-09-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO2017003070A2 (en) | Estrogen receptor modulating tetrahydro-pyrido [3,4-b] indoles and uses thereof | |
CR20170563A (en) | BENZOXACEPIN OXAZOLIDINONE COMPOUNDS AND METHODS OF USE. | |
NI201900039A (en) | DERIVATIVES OF 6, 7, 8, 9-TETRAHIDRO-3H-PIRAZOLO [4, 3-F] ISOQUINOLINE USEFUL IN THE TREATMENT OF CANCER | |
PE20151416A1 (en) | SPIRO-LACTAMA NMDA RECEIVER MODULATORS AND THEIR USES | |
CO2018013747A2 (en) | Modulators of the spiro-lactam n-methyl-d-aspartate receptor and uses thereof | |
CL2019000245A1 (en) | Moduladores nmda espiro-lactam and methods of use thereof. | |
BR112015020389A2 (en) | carbazole compounds useful as bromodomain inhibitors | |
MX2018009257A (en) | Benzimidazole derivatives as modulators of ror-gamma. | |
CL2019000248A1 (en) | Modulators of the nmda spiro-lactam receptor and use thereof | |
PE20151436A1 (en) | SPIRO-LACTAMA NMDA RECEIVER MODULATORS AND THEIR USES | |
CL2019000249A1 (en) | Modulators of the nmda spiro-lactam and bis-spiro-lactam receptor and use thereof. | |
EA201591403A1 (en) | SPIROLACTAM NMDA RECEPTOR MODULATORS AND THEIR APPLICATION | |
CO6771417A2 (en) | Lysophosphatidic acid receptor antagonists and their use in the treatment of fibrosis | |
CO2019010078A2 (en) | Pyrimidinyl-pyridyloxy-naphthyl compounds and methods for treating ire1-related diseases and disorders | |
CL2019000246A1 (en) | Modulators of the nmda spiro-lactam receptor and use thereof. | |
PE20151438A1 (en) | SPIRO-LACTAMA NMDA RECEIVER MODULATORS AND THEIR USES | |
CO2018005315A2 (en) | Modulators of the interaction of sestrina-gator2 and its uses | |
CL2019000247A1 (en) | Modulators of the nmda spiro-lactam receptor and use thereof. | |
PE20151427A1 (en) | SPIRO-LACTAMA NMDA RECEIVER MODULATORS AND THEIR USES | |
CL2015000039A1 (en) | Estra-1,3,5 (10), 16-tetraeno-3-substituted derivatives, pharmaceutical preparations that comprise them and their use in the preparation of medicaments for treating endometriosis. | |
UY33490A (en) | NEW KINOLINE ESTERS USEFUL FOR THE TREATMENT OF SKIN DISORDERS. | |
CL2017002605A1 (en) | Indole derivatives | |
AR122456A2 (en) | TETRAHYDRO-PYRIDO[3,4-B]INDOLS MODULATORS OF ESTROGEN RECEPTORS AND THEIR USES | |
UY36958A (en) | COMPOUNDS FOR INTRACELLULAR ADMINISTRATION | |
EA202192092A2 (en) | TETRAHYDROPIRIDO [3,4-b] INDOLIC ESTROGEN RECEPTOR MODULATORS AND THEIR APPLICATION |