AR121416A1 - NEW HETEROCYCLIC COMPOUNDS - Google Patents

NEW HETEROCYCLIC COMPOUNDS

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Publication number
AR121416A1
AR121416A1 ARP190100027A ARP190100027A AR121416A1 AR 121416 A1 AR121416 A1 AR 121416A1 AR P190100027 A ARP190100027 A AR P190100027A AR P190100027 A ARP190100027 A AR P190100027A AR 121416 A1 AR121416 A1 AR 121416A1
Authority
AR
Argentina
Prior art keywords
group
alkyl
halogen
hydrogen
substituted
Prior art date
Application number
ARP190100027A
Other languages
Spanish (es)
Inventor
Ann Petersen
Joerg Benz
Uwe Grether
Benoit Hornsperger
Buelent Kocer
Bernd Kuhn
Hans Richter
Satoshi Tsuchiya
Yangcheng Qiu
Rui Chen
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR121416A1 publication Critical patent/AR121416A1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Reivindicación 1: Compuesto de fórmula (1) o una sal farmacéuticamente aceptable del mismo, en la que: R¹ᵃ se selecciona del grupo que consiste en: (i) alquilo C₁₋₆, (ii) alcoxi C₁₋₆ y (iii) arilo sustituido con R², R³, R⁴, R⁵ y R⁶, o una combinación de los mismos, R¹ se selecciona de entre el grupo que consiste en: (i) arilo sustituido con R⁸, R⁹ y R¹⁰; y (ii) heteroarilo sustituido con R¹¹ y R¹²; cada R², R³, R⁴, R⁵ y R⁶ se selecciona independientemente del grupo que consiste en hidrógeno, halógeno, alcoxi, haloalcoxi, hidroxi, amino, -NH-alquilo, -N(alquilo)₂ y ciano; R⁷ se selecciona del grupo que consiste en hidrógeno, halógeno, alcoxi, cicloalquiloxi e hidroxi; cada R⁸, R⁹, R¹⁰, R¹¹ y R¹² se selecciona independientemente del grupo que consiste en hidrógeno, hidroxi, alcoxi, ciano, alcoxialquilo, haloalcoxi, halógeno, alquilo, haloalquilo, alquilsulfanilo, amino, -NH-alquilo, -N(alquilo)₂, -NH-arilo, -NH-heteroarilo y un grupo de fórmula (2); R¹³ se selecciona del grupo que consiste en hidrógeno, halógeno, alquilo, oxo, carbamoilo, carbamoilo sustituido y alcoxicarbonilo, en el que dicho carbamoilo sustituido se sustituye en el átomo de nitrógeno con uno a dos sustituyentes alquilo; R¹⁴ es hidrógeno o halógeno; L se selecciona del grupo que consiste en un enlace covalente, -CH=CH-, -O-, -CH₂O-, -OCH₂-, -CH₂- y -CH₂CH₂-; y A se selecciona del grupo que consiste en arilo, heteroarilo, cicloalquilo y heterociclilo; con la condición de que el compuesto de fórmula (1) no sea (4-fluorofenil)-[7-(4-fluorofenil)-1,3,4,6,7,8,9,9a-octahidropirido[1,2-a]pirazín-2-il]metanona.Claim 1: Compound of formula (1) or a pharmaceutically acceptable salt thereof, wherein: R¹ᵃ is selected from the group consisting of: (i) C₁₋₆ alkyl, (ii) C₁₋₆ alkoxy and (iii) aryl substituted with R², R³, R⁴, R⁵ and R⁶, or a combination thereof, R¹ is selected from the group consisting of: (i) aryl substituted with R⁸, R⁹ and R¹⁰; and (ii) heteroaryl substituted by R¹¹ and R¹²; each R², R³, R⁴, R⁵, and R⁶ is independently selected from the group consisting of hydrogen, halogen, alkoxy, haloalkoxy, hydroxy, amino, -NH-alkyl, -N(alkyl)₂, and cyano; R⁷ is selected from the group consisting of hydrogen, halogen, alkoxy, cycloalkyloxy, and hydroxy; each R⁸, R⁹, R¹⁰, R¹¹ and R¹² is independently selected from the group consisting of hydrogen, hydroxy, alkoxy, cyano, alkoxyalkyl, haloalkoxy, halogen, alkyl, haloalkyl, alkylsulfanyl, amino, -NH-alkyl, -N(alkyl) ₂, -NH-aryl, -NH-heteroaryl and a group of formula (2); R¹³ is selected from the group consisting of hydrogen, halogen, alkyl, oxo, carbamoyl, substituted carbamoyl, and alkoxycarbonyl, wherein said substituted carbamoyl is substituted on the nitrogen atom with one to two alkyl substituents; R¹⁴ is hydrogen or halogen; L is selected from the group consisting of a covalent bond, -CH=CH-, -O-, -CH₂O-, -OCH₂-, -CH₂-, and -CH₂CH₂-; and A is selected from the group consisting of aryl, heteroaryl, cycloalkyl, and heterocyclyl; with the proviso that the compound of formula (1) is not (4-fluorophenyl)-[7-(4-fluorophenyl)-1,3,4,6,7,8,9,9a-octahydropyrido[1,2 -a]pyrazin-2-yl]methanone.

ARP190100027A 2018-01-08 2019-01-07 NEW HETEROCYCLIC COMPOUNDS AR121416A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP18150649 2018-01-08

Publications (1)

Publication Number Publication Date
AR121416A1 true AR121416A1 (en) 2022-06-08

Family

ID=60937668

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP190100027A AR121416A1 (en) 2018-01-08 2019-01-07 NEW HETEROCYCLIC COMPOUNDS

Country Status (1)

Country Link
AR (1) AR121416A1 (en)

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