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Application filed by Decibel Therapeutics IncfiledCriticalDecibel Therapeutics Inc
Publication of AR120388A1publicationCriticalpatent/AR120388A1/en
Medicines Containing Material From Animals Or Micro-Organisms
(AREA)
Abstract
La descripción proporciona polinucleótidos que contienen promotores de SLC6A14, así como también vectores que los contienen, que pueden usarse para promover la expresión de un transgén en células de apoyo vestibulares. Los polinucleótidos descritos en la presente pueden unirse operativamente a un transgén, tal como un transgén que codifica una proteína terapéutica, de forma tal que promueven la expresión de la célula de apoyo vestibular del transgén. Los polinucleótidos descritos en la presente pueden unirse operativamente a un transgén terapéutico y usarse para el tratamiento de sujetos que tienen o se encuentran en riesgo de desarrollar disfunción vestibular.The disclosure provides polynucleotides containing SLC6A14 promoters, as well as vectors containing them, that can be used to promote expression of a transgene in vestibular support cells. The polynucleotides described herein can be operably linked to a transgene, such as a transgene encoding a therapeutic protein, in such a way as to promote vestibular support cell expression of the transgene. The polynucleotides described herein can be operably linked to a therapeutic transgene and used for the treatment of subjects who have or are at risk of developing vestibular dysfunction.
ARP200103058A2019-11-042020-11-04
VESTIBULAR SUPPORT CELL PROMOTERS AND THEIR USES
AR120388A1
(en)