AR120352A1 - ANTI-CD45 ANTIBODIES AND THEIR CONJUGATES - Google Patents
ANTI-CD45 ANTIBODIES AND THEIR CONJUGATESInfo
- Publication number
- AR120352A1 AR120352A1 ARP200103009A ARP200103009A AR120352A1 AR 120352 A1 AR120352 A1 AR 120352A1 AR P200103009 A ARP200103009 A AR P200103009A AR P200103009 A ARP200103009 A AR P200103009A AR 120352 A1 AR120352 A1 AR 120352A1
- Authority
- AR
- Argentina
- Prior art keywords
- cells
- antibodies
- depleting
- patient
- compositions
- Prior art date
Links
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente se refiere a anticuerpos anti-CD45, fragmentos de unión al antígeno de los mismos, y conjugados de anticuerpo-fármaco (ADC) que se unen específicamente a CD45 humano. Tales anticuerpos y ADC son útiles en métodos terapéuticos, incluyendo métodos para agotar células CD45⁺ de un paciente. Las composiciones y métodos descritos en la presente se pueden usar para tratar un trastorno directamente, por ejemplo, agotando una población de células cancerosas CD45⁺ o células autoinmunes. Las composiciones y métodos descritos en la presente también se pueden usar para preparar un paciente para terapia de trasplante de células madre hematopoyéticas, y mejorar la inserción de trasplantes de células madre hematopoyéticas, agotando selectivamente las células CD45⁺ endógenas antes del procedimiento de trasplante.The present invention relates to anti-CD45 antibodies, antigen-binding fragments thereof, and antibody-drug conjugates (ADC) that specifically bind to human CD45. Such antibodies and ADCs are useful in therapeutic methods, including methods for depleting CD45 + cells from a patient. The compositions and methods described herein can be used to treat a disorder directly, for example, by depleting a population of CD45⁺ cancer cells or autoimmune cells. The compositions and methods described herein can also be used to prepare a patient for hematopoietic stem cell transplantation therapy, and enhance the insertion of hematopoietic stem cell transplants, by selectively depleting endogenous CD45⁺ cells prior to the transplant procedure.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962929137P | 2019-11-01 | 2019-11-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR120352A1 true AR120352A1 (en) | 2022-02-09 |
Family
ID=80782234
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP200103009A AR120352A1 (en) | 2019-11-01 | 2020-10-30 | ANTI-CD45 ANTIBODIES AND THEIR CONJUGATES |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR120352A1 (en) |
-
2020
- 2020-10-30 AR ARP200103009A patent/AR120352A1/en unknown
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