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En el presente se describen procedimientos para sintetizar el ácido 5-bromo-2-(3-cloro-pirazol-2-il)-2H-pirazol-3-carboxílico a partir de pirazol o derivados de pirazol. En la presente también se describen compuestos intermedios de la reacción. Reivindicación 1: Un compuesto de la fórmula (1), en donde R⁵ es hidrógeno; cada uno de R⁶ y R¹⁰ es independientemente un halógeno; cada uno de R⁷ - R⁹ se selecciona independientemente de hidrógeno y halógeno; y R¹² es nitrilo.Methods for synthesizing 5-bromo-2-(3-chloro-pyrazol-2-yl)-2H-pyrazole-3-carboxylic acid from pyrazole or pyrazole derivatives are described herein. Reaction intermediates are also described herein. Claim 1: A compound of formula (1), wherein R⁵ is hydrogen; each of R⁶ and R¹⁰ is independently a halogen; each of R⁷-R⁹ is independently selected from hydrogen and halogen; and R¹² is nitrile.
ARP200102866A2019-10-182020-10-16
PROCEDURE FOR THE PREPARATION OF 5-BROMO-2-(3-CHLORO-PYRIDIN-2-IL)-2H-PYRAZOL-3-CARBOXYLIC ACID
AR120241A1
(en)
Processes for preparing a compound of formula ib, ic or id; and intermediate compounds to make a compound of formula ib, ic or id (div. sol. 202001814).
Synthesis of 4-amino-5-methyl-1h-pyridin-2 (1h) -on (intermediate compound for the synthesis of the antagonist mr finerenone) from 2-chloro-5-methyl-4-nitro-pyridine-1 -oxide using the intermediate 2-chloro-5-methyl-4-pyridinamine