AR119763A1 - MACROCYCLIC SULFONYLAMIDE DERIVATIVES NLRP3 INHIBITORS - Google Patents
MACROCYCLIC SULFONYLAMIDE DERIVATIVES NLRP3 INHIBITORSInfo
- Publication number
- AR119763A1 AR119763A1 ARP200102299A ARP200102299A AR119763A1 AR 119763 A1 AR119763 A1 AR 119763A1 AR P200102299 A ARP200102299 A AR P200102299A AR P200102299 A ARP200102299 A AR P200102299A AR 119763 A1 AR119763 A1 AR 119763A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- hydrocarbyl group
- optionally
- independently selected
- substituted
- Prior art date
Links
Abstract
Reivindicación 1: Un compuesto de fórmula (1) en donde: J es -SO-, -SO₂- o -SO(=NRʲ)-; Q es O ó S; X es -C(R²)₂-; L es un grupo hidrocarbileno saturado o insaturado, en donde el grupo hidrocarbileno puede ser de cadena lineal o ramificada, o puede ser o incluir uno o más grupos cíclicos, en donde el grupo hidrocarbileno puede sustituirse opcionalmente, y en donde el grupo hidrocarbileno puede incluir, opcionalmente, uno o más heteroátomos que se seleccionan independientemente de N, O y S en su esqueleto de carbono; -J-N(R¹)-C(=Q)-X- y -L- juntos forman un anillo, de forma tal que el tamaño del anillo único mínimo que abarca todo o parte de cada uno de -J-, -N(R¹)-, -C(=Q)-, -X- y -L- es de 8 a 30 átomos; cada Rʲ y R¹ se selecciona independientemente de hidrógeno o un grupo hidrocarbilo saturado o insaturado, en donde el grupo hidrocarbilo puede ser de cadena lineal o ramificada, o puede ser o incluir uno o más grupos cíclicos, en donde el grupo hidrocarbilo puede sustituirse opcionalmente, y en donde el grupo hidrocarbilo puede incluir, opcionalmente, uno o más heteroátomos que se seleccionan independientemente de N, O y S en su esqueleto de carbono; y cada R² se selecciona independientemente de hidrógeno o un halo, -OH, -NO₂, -NH₂, -N₃, -SH, -SO₂H, -SO₂NH₂, o un grupo hidrocarbilo saturado o insaturado, en donde el grupo hidrocarbilo puede ser de cadena lineal o ramificada o puede ser o incluir uno o más grupos cíclicos, en donde el grupo hidrocarbilo puede, opcionalmente ser sustituido, y en donde el grupo hidrocarbilo puede opcionalmente incluir uno o más heteroátomos N, O ó S en su esqueleto de carbono, o en donde dos R² pueden, junto con el átomo de carbono al que están unidos, formar un grupo cíclico, en donde el grupo cíclico puede opcionalmente ser sustituido.Claim 1: A compound of formula (1) wherein: J is -SO-, -SO₂- or -SO(=NRʲ)-; Q is O or S; X is -C(R²)₂-; L is a saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight or branched chain, or may be or include one or more cyclic groups, wherein the hydrocarbylene group may be optionally substituted, and wherein the hydrocarbylene group may include optionally one or more heteroatoms independently selected from N, O and S on their carbon skeleton; -J-N(R¹)-C(=Q)-X- and -L- together form a ring such that the minimum single ring size encompassing all or part of each of -J-, -N(R¹ )-, -C(=Q)-, -X- and -L- is from 8 to 30 atoms; each Rʲ and R¹ is independently selected from hydrogen or a saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight or branched chain, or may be or include one or more cyclic groups, wherein the hydrocarbyl group may be optionally substituted, and wherein the hydrocarbyl group may optionally include one or more heteroatoms independently selected from N, O and S on its carbon skeleton; and each R² is independently selected from hydrogen or a halo, -OH, -NO₂, -NH₂, -N₃, -SH, -SO₂H, -SO₂NH₂, or a saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be chain linear or branched or may be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted, and wherein the hydrocarbyl group may optionally include one or more N, O or S heteroatoms on its carbon skeleton, or wherein two R² may, together with the carbon atom to which they are attached, form a cyclic group, wherein the cyclic group may optionally be substituted.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1911781.1A GB201911781D0 (en) | 2019-08-16 | 2019-08-16 | Novel compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
AR119763A1 true AR119763A1 (en) | 2022-01-12 |
Family
ID=68099536
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP200102299A AR119763A1 (en) | 2019-08-16 | 2020-08-13 | MACROCYCLIC SULFONYLAMIDE DERIVATIVES NLRP3 INHIBITORS |
Country Status (2)
Country | Link |
---|---|
AR (1) | AR119763A1 (en) |
GB (1) | GB201911781D0 (en) |
-
2019
- 2019-08-16 GB GBGB1911781.1A patent/GB201911781D0/en not_active Ceased
-
2020
- 2020-08-13 AR ARP200102299A patent/AR119763A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
GB201911781D0 (en) | 2019-10-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR106235A1 (en) | PIRROLOBENZODIAZEPIN ANTIBODY-DRUG CONJUGATES AND METHODS OF USE | |
NI201400099A (en) | COMPOSITION FOR PEST CONTROL INCLUDING A NEW IMINOPYRIDINE DERIVATIVE | |
PE20181924A1 (en) | ARGINASE INHIBITORS AND THEIR THERAPEUTIC APPLICATIONS | |
AR112774A1 (en) | 1,2-DIHYDRO-3H-PYRAZOLO [3,4-D] PYRIMIDIN-3-ONA ANALOGUES | |
ES2044968T3 (en) | AMIDA COMPLEX. | |
BR112015023397A2 (en) | substituted benzoxazole and methods of use thereof | |
CO6180506A2 (en) | HCV PROTEASA NS3 INHIBITORS | |
PE20180600A1 (en) | METAL-BETA-LACTAMASE INHIBITORS | |
MX2016012984A (en) | Indole derivatives for use in medicine. | |
CO6700838A2 (en) | Banzamide Substituted Compounds | |
AR074773A1 (en) | PIRIDAZINONAS REPLACED WITH PHENYL IN POSITION 4, ITS USE AS HERBICIDES AND INSECTICIDES IN COMPOSITIONS AND METHODS THAT INCLUDE AND INTERMEDIATE FOR SYNTHESIS. | |
AR085806A1 (en) | GIRASA TRICICLIC INHIBITORS | |
NI201200191A (en) | INDOLIZINE DERIVATIVES, ITS PREPARATION PROCEDURE AND ITS APPLICATION IN THERAPEUTICS | |
AR067613A1 (en) | PK-DNA INHIBITORS, USE AND SYNTHESIS OF THE SAME | |
AR097543A1 (en) | COMPOUNDS BASED ON IMIDAZO [1,2-b] PIRIDAZINE, COMPOSITIONS THAT INCLUDE THEM AND THEIR METHODS OF USE | |
PE20171433A1 (en) | NEW TRITERPENONE C-3 WITH C-17 INVERSE AMIDE DERIVATIVES AS HIV INHIBITORS | |
CO6320143A1 (en) | NEW DIHYDROINDOLONE DERIVATIVES ITS PHARMACEUTICAL PREPARATION PROCEDURE AND COMPOSITIONS CONTAINING THEM | |
UY37764A (en) | NEW INHIBITING COMPOUNDS OF PROSTAGLANDINA D SINTASA HEMATOPOYÉTICA (H-PGDS) | |
CO2022008968A2 (en) | New methylquinazolinone derivatives | |
ECSP099682A (en) | NEW NITROGEN HETEROCICLICAL COMPOUNDS, ITS PREPARATION AND ITS USE AS ANTIBACTERIAL MEDICINES | |
BR112015019342A2 (en) | wide and narrow azimuth seismic data acquisition system and method | |
AR113958A1 (en) | MACROCYCLES AS INHIBITORS OF PDE1 | |
AR117472A1 (en) | RIPK2 TIENOPYRIDINE INHIBITORS | |
GT200700084A (en) | DERIVATIVES OF INDANIL-PIPERAZINAS, ITS PREPARATION PROCEDURE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | |
AR119763A1 (en) | MACROCYCLIC SULFONYLAMIDE DERIVATIVES NLRP3 INHIBITORS |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |