AR119763A1 - MACROCYCLIC SULFONYLAMIDE DERIVATIVES NLRP3 INHIBITORS - Google Patents

MACROCYCLIC SULFONYLAMIDE DERIVATIVES NLRP3 INHIBITORS

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Publication number
AR119763A1
AR119763A1 ARP200102299A ARP200102299A AR119763A1 AR 119763 A1 AR119763 A1 AR 119763A1 AR P200102299 A ARP200102299 A AR P200102299A AR P200102299 A ARP200102299 A AR P200102299A AR 119763 A1 AR119763 A1 AR 119763A1
Authority
AR
Argentina
Prior art keywords
group
hydrocarbyl group
optionally
independently selected
substituted
Prior art date
Application number
ARP200102299A
Other languages
Spanish (es)
Inventor
Matthew Cooper
David Miller
Angus Macleod
Stephen Thom
Jonathan Shannon
Celia Amparo Incerti-Pradillos
Christopher Gordon Mpherson
Original Assignee
Inflazome Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inflazome Ltd filed Critical Inflazome Ltd
Publication of AR119763A1 publication Critical patent/AR119763A1/en

Links

Abstract

Reivindicación 1: Un compuesto de fórmula (1) en donde: J es -SO-, -SO₂- o -SO(=NRʲ)-; Q es O ó S; X es -C(R²)₂-; L es un grupo hidrocarbileno saturado o insaturado, en donde el grupo hidrocarbileno puede ser de cadena lineal o ramificada, o puede ser o incluir uno o más grupos cíclicos, en donde el grupo hidrocarbileno puede sustituirse opcionalmente, y en donde el grupo hidrocarbileno puede incluir, opcionalmente, uno o más heteroátomos que se seleccionan independientemente de N, O y S en su esqueleto de carbono; -J-N(R¹)-C(=Q)-X- y -L- juntos forman un anillo, de forma tal que el tamaño del anillo único mínimo que abarca todo o parte de cada uno de -J-, -N(R¹)-, -C(=Q)-, -X- y -L- es de 8 a 30 átomos; cada Rʲ y R¹ se selecciona independientemente de hidrógeno o un grupo hidrocarbilo saturado o insaturado, en donde el grupo hidrocarbilo puede ser de cadena lineal o ramificada, o puede ser o incluir uno o más grupos cíclicos, en donde el grupo hidrocarbilo puede sustituirse opcionalmente, y en donde el grupo hidrocarbilo puede incluir, opcionalmente, uno o más heteroátomos que se seleccionan independientemente de N, O y S en su esqueleto de carbono; y cada R² se selecciona independientemente de hidrógeno o un halo, -OH, -NO₂, -NH₂, -N₃, -SH, -SO₂H, -SO₂NH₂, o un grupo hidrocarbilo saturado o insaturado, en donde el grupo hidrocarbilo puede ser de cadena lineal o ramificada o puede ser o incluir uno o más grupos cíclicos, en donde el grupo hidrocarbilo puede, opcionalmente ser sustituido, y en donde el grupo hidrocarbilo puede opcionalmente incluir uno o más heteroátomos N, O ó S en su esqueleto de carbono, o en donde dos R² pueden, junto con el átomo de carbono al que están unidos, formar un grupo cíclico, en donde el grupo cíclico puede opcionalmente ser sustituido.Claim 1: A compound of formula (1) wherein: J is -SO-, -SO₂- or -SO(=NRʲ)-; Q is O or S; X is -C(R²)₂-; L is a saturated or unsaturated hydrocarbylene group, wherein the hydrocarbylene group may be straight or branched chain, or may be or include one or more cyclic groups, wherein the hydrocarbylene group may be optionally substituted, and wherein the hydrocarbylene group may include optionally one or more heteroatoms independently selected from N, O and S on their carbon skeleton; -J-N(R¹)-C(=Q)-X- and -L- together form a ring such that the minimum single ring size encompassing all or part of each of -J-, -N(R¹ )-, -C(=Q)-, -X- and -L- is from 8 to 30 atoms; each Rʲ and R¹ is independently selected from hydrogen or a saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight or branched chain, or may be or include one or more cyclic groups, wherein the hydrocarbyl group may be optionally substituted, and wherein the hydrocarbyl group may optionally include one or more heteroatoms independently selected from N, O and S on its carbon skeleton; and each R² is independently selected from hydrogen or a halo, -OH, -NO₂, -NH₂, -N₃, -SH, -SO₂H, -SO₂NH₂, or a saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be chain linear or branched or may be or include one or more cyclic groups, wherein the hydrocarbyl group may optionally be substituted, and wherein the hydrocarbyl group may optionally include one or more N, O or S heteroatoms on its carbon skeleton, or wherein two R² may, together with the carbon atom to which they are attached, form a cyclic group, wherein the cyclic group may optionally be substituted.

ARP200102299A 2019-08-16 2020-08-13 MACROCYCLIC SULFONYLAMIDE DERIVATIVES NLRP3 INHIBITORS AR119763A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1911781.1A GB201911781D0 (en) 2019-08-16 2019-08-16 Novel compounds

Publications (1)

Publication Number Publication Date
AR119763A1 true AR119763A1 (en) 2022-01-12

Family

ID=68099536

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP200102299A AR119763A1 (en) 2019-08-16 2020-08-13 MACROCYCLIC SULFONYLAMIDE DERIVATIVES NLRP3 INHIBITORS

Country Status (2)

Country Link
AR (1) AR119763A1 (en)
GB (1) GB201911781D0 (en)

Also Published As

Publication number Publication date
GB201911781D0 (en) 2019-10-02

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