AR119696A1 - N-SUBSTITUTED INDOLES AND OTHER HETEROCYCLES TO TREAT BRAIN DISORDERS - Google Patents

N-SUBSTITUTED INDOLES AND OTHER HETEROCYCLES TO TREAT BRAIN DISORDERS

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Publication number
AR119696A1
AR119696A1 ARP200100541A ARP200100541A AR119696A1 AR 119696 A1 AR119696 A1 AR 119696A1 AR P200100541 A ARP200100541 A AR P200100541A AR P200100541 A ARP200100541 A AR P200100541A AR 119696 A1 AR119696 A1 AR 119696A1
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AR
Argentina
Prior art keywords
alkyl
cycloalkyl
heterocycloalkyl
aryl
r8br8c
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Application number
ARP200100541A
Other languages
Spanish (es)
Inventor
Florence F Wagner
Lee Dunlap
David E Olson
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Univ California filed Critical Univ California
Publication of AR119696A1 publication Critical patent/AR119696A1/en

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Abstract

Reivindicación 1: Un compuesto de fórmula (1) donde: X es CR³; R¹ᵃ y R¹ᵇ son cada uno independientemente hidrógeno, alquilo C₁₋₆, cicloalquilo C₃₋₈ o alquilo C₄₋₁₄-cicloalquilo; R¹ᶜ es alquilo C₁₋₆, cicloalquilo C₃₋₈ o alquilcicloalquilo C₄₋₁₄; alternativamente, dos de R¹ᵃ, R¹ᵇ y R¹ᶜ se combinan con los átomos a los que están unidos para formar un heterocicloalquilo C₃₋₁₂; R², R³, R⁴, R⁵, R⁶ y R⁷ son cada uno independientemente hidrógeno, alquilo C₁₋₆, alquenilo C₂₋₆, alquinilo C₂₋₆, halógeno, haloalquilo C₁₋₆, alquilamina C₁₋₆, alcoxi C₁₋₆, haloalcoxi C₁₋₆, -OR⁸ᵃ, -NO₂, -CN, -C(O)R⁸ᵇ, -C(O)OR⁸ᵇ, -OC(O)R⁸ᵇ, -OC(O)OR⁸ᵇ, -N(R⁸ᵇR⁸ᶜ), -N(R⁸ᵇ)C(O)R⁸ᶜ, -C(O)N(R⁸ᵇR⁸ᶜ), -N(R⁸ᵇ)C(O)OR⁸ᶜ, -OC(O)N(R⁸ᵇR⁸ᶜ), -N(R⁸ᵇ)C(O)N(R⁸ᶜR⁸ᵈ), -C(O)C(O)N(R⁸ᵇR⁸ᶜ), -S(O₂)R⁸ᵇ, -S(O)₂N(R⁸ᵇR⁸ᶜ), cicloalquilo C₃₋₈, cicloalquilo C₃₋₁₄, heterocicloalquilo C₄₋₁₀, alquil C₄₋₁₆-heterocicloalquilo, arilo C₆₋₁₂, alquil C₇₋₁₈-arilo, heteroarilo C₅₋₁₀, o alquil C₄₋₁₆-heteroarilo; R⁸ᵃ es cicloalquilo C₃₋₈, alquil-cicloalquilo C₃₋₁₄, heterocicloalquilo C₄₋₁₀, alquil-heterocicloalquilo C₄₋₁₆, arilo C₆₋₁₂, alquil-arilo C₇₋₁₈, heteroarilo C₅₋₁₀ o alquil-heteroarilo C₄₋₁₆; R⁸ᵇ, R⁸ᶜ y R⁸ᵈ son cada uno independientemente H o alquilo C₁₋₆; alternativamente, uno de R¹ᵃ, R¹ᵇ o R¹ᶜ se combina con R² para formar un heterocicloalquilo C₅₋₁₂; alternativamente, R² y R³ se combinan con los átomos a los que están unidos para formar un cicloalquilo C₄₋₈, heterocicloalquilo C₄₋₁₀ o arilo C₆₋₁₂; alternativamente, R⁴ y R⁵, R⁵ y R⁶, o R⁶ y R⁷ se combinan con los átomos a los que están unidos para formar un cicloalquilo C₄₋₆, heterocicloalquilo C₄₋₆, arilo C₆₋₁₂ o heteroarilo C₅₋₁₀; y L es alquileno C₁₋₆, o sales farmacéuticamente aceptables e isómeros de los mismos, en donde cuando R¹ᵃ, R¹ᵇ y R¹ᶜ son cada uno Me, L es metileno, X es CR³ y R², R³, R⁴, R⁵, R⁶ y R⁷ son hidrógeno, entonces el compuesto es de fórmula (2) ó (3), y en donde el compuesto es distinto de los restos del grupo de fórmulas (4).Claim 1: A compound of formula (1) where: X is CR³; R¹ᵃ and R¹ᵇ are each independently hydrogen, C₁₋₆ alkyl, C₃₋₈ cycloalkyl, or C₄₋₁₄ alkyl-cycloalkyl; R¹ᶜ is C₁₋₆ alkyl, C₃₋₈ cycloalkyl or C₄₋₁₄ alkylcycloalkyl; alternatively, two of R¹ᵃ, R¹ᵇ and R¹ᶜ combine with the atoms to which they are attached to form a C₃₋₁₂ heterocycloalkyl; R², R³, R⁴, R⁵, R⁶ and R⁷ are each independently hydrogen, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, halogen, C₁₋₆ haloalkyl, C₁₋₆ alkylamine, C₁₋₆ alkoxy, haloalkoxy C₁₋₆, -OR⁸ᵃ, -NO₂, -CN, -C(O)R⁸ᵇ, -C(O)OR⁸ᵇ, -OC(O)R⁸ᵇ, -OC(O)OR⁸ᵇ, -N(R⁸ᵇR⁸ᶜ), -N( R⁸ᵇ)C(O)R⁸ᶜ, -C(O)N(R⁸ᵇR⁸ᶜ), -N(R⁸ᵇ)C(O)OR⁸ᶜ, -OC(O)N(R⁸ᵇR⁸ᶜ), -N(R⁸ᵇ)C(O)N( R⁸ᶜR⁸ᵈ), -C(O)C(O)N(R⁸ᵇR⁸ᶜ), -S(O₂)R⁸ᵇ, -S(O)₂N(R⁸ᵇR⁸ᶜ), C₃₋₈ cycloalkyl, C₃₋₁₄ cycloalkyl, C₄₋₁₁ heterocycloalkyl, alkyl C₄₋₁₆-heterocycloalkyl, C₆₋₁₂-aryl, C₇₋₁₈-alkyl-aryl, C₅₋₁₀-heteroaryl, or C₄₋₁₆-alkyl-heteroaryl; R⁸ᵃ is C₃₋₈ cycloalkyl, C₃₋₁₄ alkyl-cycloalkyl, c₄₋₁₀ heterocycloalkyl, C₄₋₁₆ alkyl-heterocycloalkyl, C₆₋₁₆₋₁ aryl, C₇₋₁₈ alkyl-aryl, heteroaryl C₅₋₁₀ or alkyl-heteroaryl C₄₋₁₆; R⁸ᵇ, R⁸ᶜ and R⁸ᵈ are each independently H or C₁₋₆ alkyl; alternatively, one of R¹ᵃ, R¹ᵇ or R¹ᶜ combines with R² to form a C₅₋₁₂ heterocycloalkyl; alternatively, R² and R³ combine with the atoms to which they are attached to form C₄₋₈ cycloalkyl, C₄₋₁₀ heterocycloalkyl, or C₆₋₁₂ aryl; alternatively, R⁴ and R⁵, R⁵ and R⁶, or R⁶ and R⁷ combine with the atoms to which they are attached to form a C₄₋₆ cycloalkyl, C₄₋₆ heterocycloalkyl, C₆₋₁₂ aryl, or C₅₋₁₀ heteroaryl; and L is C₁₋₆ alkylene, or pharmaceutically acceptable salts and isomers thereof, wherein when R¹ᵃ, R¹ᵇ and R¹ᶜ are each Me, L is methylene, X is CR³ and R², R³, R⁴, R⁵, R⁶ and R⁷ are hydrogen, then the compound is of formula (2) or (3), and wherein the compound is other than the moieties of the group of formulas (4).

ARP200100541A 2019-02-27 2020-02-27 N-SUBSTITUTED INDOLES AND OTHER HETEROCYCLES TO TREAT BRAIN DISORDERS AR119696A1 (en)

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US201962811206P 2019-02-27 2019-02-27

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AR119696A1 true AR119696A1 (en) 2022-01-05

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