AR119478A2 - INTERMEDIATE COMPOUND USEFUL IN THE PREPARATION OF 2-(TER-BUTYLAMINO)-4-((1R,3R,4R)-3-HYDROXY-4-METHYLCYCLOHEXYLAMINO)-PYRIMIDINE-5-CARBOXAMIDE AND METHODS OF PREPARING INTERMEDIARIES - Google Patents

INTERMEDIATE COMPOUND USEFUL IN THE PREPARATION OF 2-(TER-BUTYLAMINO)-4-((1R,3R,4R)-3-HYDROXY-4-METHYLCYCLOHEXYLAMINO)-PYRIMIDINE-5-CARBOXAMIDE AND METHODS OF PREPARING INTERMEDIARIES

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Publication number
AR119478A2
AR119478A2 ARP200102077A ARP200102077A AR119478A2 AR 119478 A2 AR119478 A2 AR 119478A2 AR P200102077 A ARP200102077 A AR P200102077A AR P200102077 A ARP200102077 A AR P200102077A AR 119478 A2 AR119478 A2 AR 119478A2
Authority
AR
Argentina
Prior art keywords
carboxamide
preparing
methylcyclohexylamino
intermediaries
butylamino
Prior art date
Application number
ARP200102077A
Other languages
Spanish (es)
Inventor
Antonio Christian Ferretti
Hon Man
- Muslehiddinoglu Jale Wah
Jean Xu
Kelvin Hin Yong
- Beauchamps Marie Georges Yeong
Mohit Atul Kothare
Nanfei Zou
Nathan Andrew Boersen
Ying Li
Ying Ye
Original Assignee
Signal Pharm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Signal Pharm Llc filed Critical Signal Pharm Llc
Publication of AR119478A2 publication Critical patent/AR119478A2/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un compuesto que tiene la fórmula (1), y tautómeros de estos, en donde R² es alquil-C₁₋₈ sustituido o no sustituido, o cicloalquilo saturado sustituido. Método para preparar un compuesto de fórmula (1), en donde la etapa de preparación comprende poner en contacto 2,4-dicloropirimidina-5-carboxamida con R²NH₂ en presencia de una base en un disolvente.A compound having the formula (1), and tautomers thereof, wherein R² is substituted or unsubstituted C₁₋₈-alkyl, or substituted saturated cycloalkyl. Method for preparing a compound of formula (1), wherein the preparation step comprises contacting 2,4-dichloropyrimidine-5-carboxamide with R²NH₂ in the presence of a base in a solvent.

ARP200102077A 2014-01-30 2020-07-23 INTERMEDIATE COMPOUND USEFUL IN THE PREPARATION OF 2-(TER-BUTYLAMINO)-4-((1R,3R,4R)-3-HYDROXY-4-METHYLCYCLOHEXYLAMINO)-PYRIMIDINE-5-CARBOXAMIDE AND METHODS OF PREPARING INTERMEDIARIES AR119478A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461933636P 2014-01-30 2014-01-30

Publications (1)

Publication Number Publication Date
AR119478A2 true AR119478A2 (en) 2021-12-22

Family

ID=58698833

Family Applications (3)

Application Number Title Priority Date Filing Date
ARP150100267A AR101641A1 (en) 2014-01-30 2015-01-29 SOLID FORMS OF 2- (TER-BUTILAMINO) -4 - ((1R, 3R, 4R) -3-HYDROXI-4-METHYLCIHYLLAMIN) -PIRIMIDINE-5-CARBOXAMIDE, ITS COMPOSITIONS AND METHODS OF USE
ARP200102076A AR119477A2 (en) 2014-01-30 2020-07-23 SOLID AMORPHOUS FORMS OF 2-(TER-BUTYLAMINO)-4-((1R,3R,4R)-3-HYDROXY-4-METHYLCOHEXYLAMINO)-PYRIMIDINE-5-CARBOXAMIDE AND SUCH CRYSTALLINE FORMS FOR USE IN THE TREATMENT OF A DISEASE
ARP200102077A AR119478A2 (en) 2014-01-30 2020-07-23 INTERMEDIATE COMPOUND USEFUL IN THE PREPARATION OF 2-(TER-BUTYLAMINO)-4-((1R,3R,4R)-3-HYDROXY-4-METHYLCYCLOHEXYLAMINO)-PYRIMIDINE-5-CARBOXAMIDE AND METHODS OF PREPARING INTERMEDIARIES

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ARP150100267A AR101641A1 (en) 2014-01-30 2015-01-29 SOLID FORMS OF 2- (TER-BUTILAMINO) -4 - ((1R, 3R, 4R) -3-HYDROXI-4-METHYLCIHYLLAMIN) -PIRIMIDINE-5-CARBOXAMIDE, ITS COMPOSITIONS AND METHODS OF USE
ARP200102076A AR119477A2 (en) 2014-01-30 2020-07-23 SOLID AMORPHOUS FORMS OF 2-(TER-BUTYLAMINO)-4-((1R,3R,4R)-3-HYDROXY-4-METHYLCOHEXYLAMINO)-PYRIMIDINE-5-CARBOXAMIDE AND SUCH CRYSTALLINE FORMS FOR USE IN THE TREATMENT OF A DISEASE

Country Status (2)

Country Link
AR (3) AR101641A1 (en)
ZA (1) ZA201704927B (en)

Also Published As

Publication number Publication date
AR119477A2 (en) 2021-12-22
ZA201704927B (en) 2018-12-19
AR101641A1 (en) 2017-01-04

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AR119478A2 (en) INTERMEDIATE COMPOUND USEFUL IN THE PREPARATION OF 2-(TER-BUTYLAMINO)-4-((1R,3R,4R)-3-HYDROXY-4-METHYLCYCLOHEXYLAMINO)-PYRIMIDINE-5-CARBOXAMIDE AND METHODS OF PREPARING INTERMEDIARIES