AR119173A1 - GLUCAGON-LIKE PEPTIDE-1 RECEPTOR AGONISTS - Google Patents

GLUCAGON-LIKE PEPTIDE-1 RECEPTOR AGONISTS

Info

Publication number
AR119173A1
AR119173A1 ARP200101699A ARP200101699A AR119173A1 AR 119173 A1 AR119173 A1 AR 119173A1 AR P200101699 A ARP200101699 A AR P200101699A AR P200101699 A ARP200101699 A AR P200101699A AR 119173 A1 AR119173 A1 AR 119173A1
Authority
AR
Argentina
Prior art keywords
glucagon
peptide
receptor agonists
compound
formula
Prior art date
Application number
ARP200101699A
Other languages
Spanish (es)
Inventor
David Andrew Coates
Todd Fields
Joseph Daniel Ho
Fucheng Qu
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR119173A1 publication Critical patent/AR119173A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

En una modalidad, la presente proporciona un compuesto de la fórmula (1) o una sal farmacéuticamente aceptable del mismo, y métodos para usar este compuesto en el tratamiento de la diabetes mellitus tipo II. Reivindicación 1: Un compuesto de la fórmula (1) en donde R¹ es H o F; R² es H o F; y R³ es H o CH₃; o una sal farmacéuticamente aceptable del mismo.In one embodiment, the present provides a compound of formula (1) or a pharmaceutically acceptable salt thereof, and methods of using this compound in the treatment of type II diabetes mellitus. Claim 1: A compound of formula (1) wherein R¹ is H or F; R² is H or F; and R³ is H or CH₃; or a pharmaceutically acceptable salt thereof.

ARP200101699A 2019-06-28 2020-06-17 GLUCAGON-LIKE PEPTIDE-1 RECEPTOR AGONISTS AR119173A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201962868117P 2019-06-28 2019-06-28

Publications (1)

Publication Number Publication Date
AR119173A1 true AR119173A1 (en) 2021-12-01

Family

ID=80781601

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP200101699A AR119173A1 (en) 2019-06-28 2020-06-17 GLUCAGON-LIKE PEPTIDE-1 RECEPTOR AGONISTS

Country Status (2)

Country Link
AR (1) AR119173A1 (en)
MA (1) MA56391B1 (en)

Also Published As

Publication number Publication date
MA56391B1 (en) 2023-11-30
MA56391A (en) 2022-05-04

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