AR118959A1 - A PROCEDURE FOR THE MANUFACTURE OF (2S,3S,4S,5R,6S)-3,4,5-TRIHYDROXI-6-(((4AR,10AR)-7-HYDROXI-1-PROPYL-1,2,3 ACID ,4,4A,5,10,10A-OCTAHYDROBENZO[G]QUINOLIN-6-IL)OXI)TETRAHYDRO-2H-PYRAN-2-CARBOXYLIC - Google Patents

A PROCEDURE FOR THE MANUFACTURE OF (2S,3S,4S,5R,6S)-3,4,5-TRIHYDROXI-6-(((4AR,10AR)-7-HYDROXI-1-PROPYL-1,2,3 ACID ,4,4A,5,10,10A-OCTAHYDROBENZO[G]QUINOLIN-6-IL)OXI)TETRAHYDRO-2H-PYRAN-2-CARBOXYLIC

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Publication number
AR118959A1
AR118959A1 ARP200101414A ARP200101414A AR118959A1 AR 118959 A1 AR118959 A1 AR 118959A1 AR P200101414 A ARP200101414 A AR P200101414A AR P200101414 A ARP200101414 A AR P200101414A AR 118959 A1 AR118959 A1 AR 118959A1
Authority
AR
Argentina
Prior art keywords
compound
formula below
preparation
pyran
tetrahydro
Prior art date
Application number
ARP200101414A
Other languages
Spanish (es)
Inventor
Martin Juhl
Frans Dennis Therkelsen
Tobias Gylling Frihed
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of AR118959A1 publication Critical patent/AR118959A1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Reivindicación 1: Un procedimiento para la preparación de compuesto (1d) con la fórmula que figura a continuación a partir de compuesto (1) con la fórmula que figura a continuación que comprende la siguiente etapa 1) hacer reaccionar compuesto (1), o una sal del mismo con haluro de bencilo para obtener compuesto (A2) de acuerdo con el esquema de reacción (1) que figura a continuación en donde X se selecciona entre el grupo que consiste en Cl, Br e I. Reivindicación 4: Un procedimiento para la preparación de compuesto (1d) con la fórmula que figura a continuación a partir de compuesto (1) con la fórmula que figura a continuación que comprende la siguiente etapa 2) someter compuesto (A2) a una reacción de desbencilación para obtener compuesto (A3), o una sal del mismo de acuerdo con el esquema de reacción (2) que figura a continuación. Reivindicación 10: Un procedimiento para la preparación de compuesto (1d) con la fórmula que figura a continuación a partir de compuesto (1) con la fórmula que figura a continuación que comprende la siguiente etapa 3) hacer reaccionar compuesto (A3) o una sal del mismo con triacetato de (2S,3S,4S,5R,6R)-2-(metoxicarbonil)-6-(2,2,2-tricloro-1-iminoetoxi)tetrahidro-2H-piran-3,4,5-triilo para obtener compuesto (A4) de acuerdo con el esquema de reacción (3) que figura a continuación. Reivindicación 13: Un procedimiento para la preparación de compuesto (1d) con la fórmula que figura a continuación a partir de compuesto (1) con la fórmula que figura a continuación que comprende la siguiente etapa 4) hacer reaccionar compuesto (A4) con hidróxido de metal alcalino para obtener (A5-Y) de acuerdo con el siguiente esquema de reacción (4) en donde Y se selecciona de Li, Na y K. Reivindicación 17: Un procedimiento para la preparación de compuesto (1d) con la fórmula que figura a continuación a partir de compuesto (1) con la fórmula que figura a continuación que comprende la siguiente etapa 5) desbencilar compuesto (A5-Y) para obtener compuesto (1d) de acuerdo con el esquema de reacción (5) que figura a continuación.Claim 1: A process for the preparation of compound (1d) with the formula below from compound (1) with the formula below comprising the following step 1) reacting compound (1), or a salt thereof with benzyl halide to obtain compound (A2) according to reaction scheme (1) below, wherein X is selected from the group consisting of Cl, Br and I. Claim 4: A process for the preparation of compound (1d) with the formula below from compound (1) with the formula below comprising the following step 2) subjecting compound (A2) to a debenzylation reaction to obtain compound (A3 ), or a salt thereof according to reaction scheme (2) below. Claim 10: A process for the preparation of compound (1d) with the formula below from compound (1) with the formula below comprising the following step 3) reacting compound (A3) or a salt thereof with (2S,3S,4S,5R,6R)-2-(methoxycarbonyl)-6-(2,2,2-trichloro-1-iminoethoxy)tetrahydro-2H-pyran-3,4,5- triyl to obtain compound (A4) according to reaction scheme (3) below. Claim 13: A process for the preparation of compound (1d) with the formula below from compound (1) with the formula below comprising the following step 4) reacting compound (A4) with sodium hydroxide alkali metal to obtain (A5-Y) according to the following reaction scheme (4) where Y is selected from Li, Na and K. Claim 17: A process for the preparation of compound (1d) with the formula shown then from compound (1) with the formula below comprising the following step 5) debenzylate compound (A5-Y) to obtain compound (1d) according to reaction scheme (5) below .

ARP200101414A 2019-05-20 2020-05-19 A PROCEDURE FOR THE MANUFACTURE OF (2S,3S,4S,5R,6S)-3,4,5-TRIHYDROXI-6-(((4AR,10AR)-7-HYDROXI-1-PROPYL-1,2,3 ACID ,4,4A,5,10,10A-OCTAHYDROBENZO[G]QUINOLIN-6-IL)OXI)TETRAHYDRO-2H-PYRAN-2-CARBOXYLIC AR118959A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA201900599 2019-05-20

Publications (1)

Publication Number Publication Date
AR118959A1 true AR118959A1 (en) 2021-11-10

Family

ID=80053366

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP200101414A AR118959A1 (en) 2019-05-20 2020-05-19 A PROCEDURE FOR THE MANUFACTURE OF (2S,3S,4S,5R,6S)-3,4,5-TRIHYDROXI-6-(((4AR,10AR)-7-HYDROXI-1-PROPYL-1,2,3 ACID ,4,4A,5,10,10A-OCTAHYDROBENZO[G]QUINOLIN-6-IL)OXI)TETRAHYDRO-2H-PYRAN-2-CARBOXYLIC

Country Status (1)

Country Link
AR (1) AR118959A1 (en)

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