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Publication of AR118957A1publicationCriticalpatent/AR118957A1/en
Micro-Organisms Or Cultivation Processes Thereof
(AREA)
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Abstract
La presente divulgación proporciona moléculas de unión a CD19 que se unen específicamente a CD19, incluyendo moléculas de unión monoespecíficas, biespecíficas y triespecíficas, conjugados que comprenden las moléculas de unión a CD19, y composiciones farmacéuticas que comprenden las moléculas de unión a CD19 y los conjugados. La divulgación proporciona además métodos de uso de las moléculas de unión a C19 para tratar enfermedades y trastornos asociados con la expresión de CD19. La divulgación proporciona aún adicionalmente células huésped recombinantes modificadas por ingeniería genética para expresar las moléculas de unión a CD19 y métodos de producción de las moléculas de unión a CD19 mediante cultivo de las células huésped en condiciones en las que las moléculas de unión a CD19 se expresan.The present disclosure provides CD19-binding molecules that specifically bind to CD19, including monospecific, bispecific, and trispecific binding molecules, conjugates comprising the CD19-binding molecules, and pharmaceutical compositions comprising the CD19-binding molecules and conjugates. . The disclosure further provides methods of using the C19-binding molecules to treat diseases and disorders associated with CD19 expression. The disclosure still further provides recombinant host cells genetically engineered to express the CD19-binding molecules and methods of producing the CD19-binding molecules by culturing the host cells under conditions in which the CD19-binding molecules are expressed. .
ARP200101412A2019-05-212020-05-19
CD19-BINDING MOLECULES AND USES THEREOF
AR118957A1
(en)
ISOLATED NUCLEIC ACID MOLECULES, ISOLATED POLYPEPTIDE MOLECULES, ISOLATED CAR MOLECULES, ANTI-EGFRVIII BINDING DOMAIN, VECTOR, CELL AND USE OF AN EFFECTIVE AMOUNT THEREOF, AND METHODS FOR PRODUCING A CELL AND PRODUCING A POPULATION OF CELLS MODIFIED BY RNA