AR117721A2 - HUMAN ANTIBODIES TO FEL D1 AND METHODS OF USING THEM - Google Patents
HUMAN ANTIBODIES TO FEL D1 AND METHODS OF USING THEMInfo
- Publication number
- AR117721A2 AR117721A2 ARP190103734A ARP190103734A AR117721A2 AR 117721 A2 AR117721 A2 AR 117721A2 AR P190103734 A ARP190103734 A AR P190103734A AR P190103734 A ARP190103734 A AR P190103734A AR 117721 A2 AR117721 A2 AR 117721A2
- Authority
- AR
- Argentina
- Prior art keywords
- antibodies
- fel
- allergen
- methods
- basophils
- Prior art date
Links
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- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente proporciona anticuerpos que se unen al alérgeno de gato, Fel d1, composiciones que comprenden los anticuerpos, ácidos nucleicos que codifican los anticuerpos y métodos de uso de los anticuerpos. De acuerdo con determinadas formas de realización de la presente, los anticuerpos son anticuerpos monoclonales totalmente humanos que se unen a Fel d1. Los anticuerpos de la presente son útiles para fijarse al alérgeno Fel d1 in vivo, con lo que se impide la unión del alérgeno Fel d1 a la IgE preformada sobre la superficie de mastocitos o basófilos. Al hacer esto, los anticuerpos impiden que se libere la histamina y otros mediadores inflamatorios de los mastocitos y/o basófilos, con lo cual se mejora la respuesta inconveniente al alérgeno de gato en individuos sensibilizados. Los anticuerpos de la presente también pueden servir como elementos de diagnóstico para determinar si un paciente es alérgico al alérgeno Fel d1 de gato.The present invention provides antibodies that bind to the cat allergen, Fel d1, compositions comprising the antibodies, nucleic acids encoding the antibodies, and methods of using the antibodies. According to certain embodiments herein, the antibodies are fully human monoclonal antibodies that bind to Fel d1. The antibodies herein are useful for binding to the Fel d1 allergen in vivo, thereby preventing the binding of the Fel d1 allergen to preformed IgE on the surface of mast cells or basophils. By doing this, the antibodies prevent histamine and other inflammatory mediators from being released from mast cells and / or basophils, thereby enhancing the undesirable response to cat allergen in sensitized individuals. The antibodies herein can also serve as diagnostic tools to determine if a patient is allergic to the cat allergen Fel d1.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261642083P | 2012-05-03 | 2012-05-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR117721A2 true AR117721A2 (en) | 2021-08-25 |
Family
ID=77568295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP190103734A AR117721A2 (en) | 2012-05-03 | 2019-12-18 | HUMAN ANTIBODIES TO FEL D1 AND METHODS OF USING THEM |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR117721A2 (en) |
-
2019
- 2019-12-18 AR ARP190103734A patent/AR117721A2/en unknown
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