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Application filed by Bioatla LlcfiledCriticalBioatla Llc
Publication of AR117660A1publicationCriticalpatent/AR117660A1/en
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents
(AREA)
Peptides Or Proteins
(AREA)
Abstract
Un polipéptido que tiene una región variable de cadena pesada y/o región variable de cadena ligera que se une específicamente a la proteína CTLA4, así cono anticuerpos y fragmentos de anticuerpos que contienen la región variable de cadena pesada y/o la región variable de cadena ligera que se unen a la proteína CTLA4. También se proporcionan composiciones farmacéuticas y kits que comprenden el polipéptido o anticuerpos y fragmentos de anticuerpo que contienen el polipéptido.A polypeptide having a heavy chain variable region and / or light chain variable region that specifically binds to the CTLA4 protein, as well as antibodies and antibody fragments that contain the heavy chain variable region and / or the chain variable region light that bind to the CTLA4 protein. Also provided are pharmaceutical compositions and kits comprising the polypeptide or antibodies and antibody fragments containing the polypeptide.
ARP190103142A2018-10-312019-10-30
ANTI-CTLA4 ANTIBODIES, ANTIBODY FRAGMENTS, THEIR IMMUNOCONJUGATES AND USES THEREOF
AR117660A1
(en)
Stable formulations of anti-ctla4 antibodies alone and in combination with antibodies against programmed death receptor 1 (pd-1) and methods for their use