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Application filed by Ottawa Hospital Res Inst, Turnstone Biologics CorpfiledCriticalOttawa Hospital Res Inst
Publication of AR117470A1publicationCriticalpatent/AR117470A1/en
Medicines Containing Material From Animals Or Micro-Organisms
(AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines
(AREA)
Abstract
La solicitud se refiere a vectores de orthopoxvirus modificados, así como a métodos para utilizar los mismos para el tratamiento de diversos cánceres. La solicitud provee vectores de orthopoxvirus modificados que exhiben varias actividades terapéuticas beneficiosas, incluyendo aumentadas actividad oncolítica, dispersión de la infección, evasión inmune, persistencia tumoral, capacidad de incorporación de secuencias de ADN exógenas, adaptabilidad para fabricación a gran escala y seguridad.The application relates to modified orthopoxvirus vectors, as well as methods for using the same for the treatment of various cancers. The application provides modified orthopoxvirus vectors that exhibit various beneficial therapeutic activities, including increased oncolytic activity, spread of infection, immune evasion, tumor persistence, ability to incorporate exogenous DNA sequences, adaptability for large-scale manufacturing, and safety.