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Application filed by Global Blood Therapeutics IncfiledCriticalGlobal Blood Therapeutics Inc
Publication of AR117112A1publicationCriticalpatent/AR117112A1/en
La presente descripción se refiere en general a compuestos y composiciones farmacéuticas adecuadas como moduladores de la hemoglobina, y a métodos para su uso en el tratamiento de trastornos mediados por la hemoglobina. Reivindicación 1: Un compuesto de fórmula (1), o un análogo isotópicamente enriquecido, estereoisómero, mezcla de estereoisómeros, o profármaco de los mismos, o una sal farmacéuticamente aceptable de cada uno de ellos, en donde: X es CH o N; Y es CH o N; Z está ausente, CH₂, O, o S; y R¹ es mono-hidroxi-(alquiloC₁₋₄), di-hidroxi-(alquiloC₁₋₄), -CH₂CH₂OCH₃, -CH₂CH₂CN, o un resto de fórmula (2).The present description relates generally to compounds and pharmaceutical compositions suitable as hemoglobin modulators, and to methods for their use in the treatment of hemoglobin-mediated disorders. Claim 1: A compound of formula (1), or an isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, or a pharmaceutically acceptable salt of each, wherein: X is CH or N; Y is CH or N; Z is absent, CH₂, O, or S; and R¹ is mono-hydroxy- (C₁₋₄-alkyl), di-hydroxy- (C₁₋₄-alkyl), -CH₂CH₂OCH₃, -CH₂CH₂CN, or a moiety of formula (2).
IMIDAZO DERIVATIVES [4,5-C] PIRIDIN-2-ONA, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, PROCEDURE FOR THE PREPARATION AND USE OF THE SAME AS ANTIVIRAL AGENTS.
REPLACED KINOLINES, COMPOSITIONS AND COMBINATIONS THAT INCLUDE THEM AND THE USE OF THEM IN THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF INFLAMMATORY AND / OR ALLERGIC DISEASES OF THE RESPIRATORY TRACT.
DERIVATIVES OF REPLACED PYRIDINONES, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USES AS ANTAGONISTS IN DISORDERS ASSOCIATED WITH RECEPTORS OF THE TYPE OF MELANINE HORMONE (MCH-1 OR MCHR-1)
Compounds derived from alkyl sulfonic acid amide; pharmaceutical composition; use of the compounds as modulators of glutamate dysfunction to prevent or treat neurological and psychiatric disorders such as schizophrenia, Alzheimer's disease, attention deficit / hyperactivity disorders, hearing loss, among others.