AR115601A1 - NECTIN-4 SPECIFIC BICYCLIC PEPTIDIC LINKS - Google Patents

NECTIN-4 SPECIFIC BICYCLIC PEPTIDIC LINKS

Info

Publication number
AR115601A1
AR115601A1 ARP190101723A ARP190101723A AR115601A1 AR 115601 A1 AR115601 A1 AR 115601A1 AR P190101723 A ARP190101723 A AR P190101723A AR P190101723 A ARP190101723 A AR P190101723A AR 115601 A1 AR115601 A1 AR 115601A1
Authority
AR
Argentina
Prior art keywords
nectin
peptidic
links
drug conjugates
specific bicyclic
Prior art date
Application number
ARP190101723A
Other languages
Spanish (es)
Inventor
Michael Rigby
Rietschoten Katerine Van
Peter Park
Gemma Mudd
Liuhong Chen
Paul Beswick
Original Assignee
Bicycletx Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bicycletx Ltd filed Critical Bicycletx Ltd
Publication of AR115601A1 publication Critical patent/AR115601A1/en

Links

Landscapes

  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente se refiere a polipéptidos que se hallan covalentemente unidos a andamios moleculares de manera que dos o más bucles peptídicos se encuentran delimitados entre puntos de unión al andamio. En particular, la presente describe péptidos que son enlazantes de alta afinidad de la Nectina-4. La presente también incluye conjugados de fármacos que comprenden dichos péptidos, conjugados a uno o más grupos efectores y/o funcionales, composiciones farmacéuticas que comprenden tales ligandos peptídicos y conjugados de fármacos y uso de los ligandos peptídicos y conjugados de fármacos en la prevención, supresión o tratamiento de una enfermedad o un trastorno mechado por la Nectina-4.This refers to polypeptides that are covalently linked to molecular scaffolds such that two or more peptide loops are bounded between points of attachment to the scaffold. In particular, this describes peptides that are high affinity linkers for Nectin-4. The present also includes drug conjugates comprising said peptides, conjugates to one or more effector and / or functional groups, pharmaceutical compositions comprising such peptide ligands and drug conjugates, and use of the peptide ligands and drug conjugates in prevention, suppression or treatment of a disease or disorder caused by Nectin-4.

ARP190101723A 2018-06-22 2019-06-21 NECTIN-4 SPECIFIC BICYCLIC PEPTIDIC LINKS AR115601A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1810250.9A GB201810250D0 (en) 2018-06-22 2018-06-22 Bicycle peptide ligands specific for nectin-4

Publications (1)

Publication Number Publication Date
AR115601A1 true AR115601A1 (en) 2021-02-03

Family

ID=63042642

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP190101723A AR115601A1 (en) 2018-06-22 2019-06-21 NECTIN-4 SPECIFIC BICYCLIC PEPTIDIC LINKS

Country Status (2)

Country Link
AR (1) AR115601A1 (en)
GB (1) GB201810250D0 (en)

Also Published As

Publication number Publication date
GB201810250D0 (en) 2018-08-08

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