AR115505A1 - MODIFIED GUIDELINES FROM RNA FOR GENE EDITING - Google Patents

MODIFIED GUIDELINES FROM RNA FOR GENE EDITING

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Publication number
AR115505A1
AR115505A1 ARP190101567A ARP190101567A AR115505A1 AR 115505 A1 AR115505 A1 AR 115505A1 AR P190101567 A ARP190101567 A AR P190101567A AR P190101567 A ARP190101567 A AR P190101567A AR 115505 A1 AR115505 A1 AR 115505A1
Authority
AR
Argentina
Prior art keywords
rna
gene editing
sgrna
short
modified
Prior art date
Application number
ARP190101567A
Other languages
Spanish (es)
Original Assignee
Intellia Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intellia Therapeutics Inc filed Critical Intellia Therapeutics Inc
Publication of AR115505A1 publication Critical patent/AR115505A1/en

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  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Esta divulgación se relaciona con guías modificadas de ARN que tienen actividad mejorada in vitro e in vivo en métodos de edición génica. Reivindicación 1: Un ARN guía (ARNg) que es un ARN guía simple corto (ARNsg corto) que comprende una porción conservada de un ARNsg que comprende una región horquilla, donde la región horquilla carece de al menos 5 - 10 nucleótidos y donde el ARNsg corto comprende una modificación en el extremo 5’ o una modificación en el extremo 3’.This disclosure relates to modified RNA guides that have improved in vitro and in vivo activity in gene editing methods. Claim 1: A guide RNA (gRNA) which is a short simple guide RNA (short sgRNA) comprising a conserved portion of a sgRNA comprising a hairpin region, where the hairpin region lacks at least 5-10 nucleotides and where the sgRNA short comprises a modification at the 5 'end or a modification at the 3' end.

ARP190101567A 2018-06-08 2019-06-07 MODIFIED GUIDELINES FROM RNA FOR GENE EDITING AR115505A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862682820P 2018-06-08 2018-06-08

Publications (1)

Publication Number Publication Date
AR115505A1 true AR115505A1 (en) 2021-01-27

Family

ID=74446291

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP190101567A AR115505A1 (en) 2018-06-08 2019-06-07 MODIFIED GUIDELINES FROM RNA FOR GENE EDITING

Country Status (1)

Country Link
AR (1) AR115505A1 (en)

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