AR115458A1 - ION CHANNEL MODULATORS - Google Patents
ION CHANNEL MODULATORSInfo
- Publication number
- AR115458A1 AR115458A1 ARP190101471A ARP190101471A AR115458A1 AR 115458 A1 AR115458 A1 AR 115458A1 AR P190101471 A ARP190101471 A AR P190101471A AR P190101471 A ARP190101471 A AR P190101471A AR 115458 A1 AR115458 A1 AR 115458A1
- Authority
- AR
- Argentina
- Prior art keywords
- 4alkyl
- 4haloalkyl
- hydrogen
- compound
- formula
- Prior art date
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Reivindicación 1: Un compuesto que tiene la fórmula (1), o una sal farmacéuticamente aceptable del mismo, donde X e Y son en forma independiente entre sí CRᵈ o N; R¹ es un resto de fórmula (2), C₃₋₆cicloalquilo monocíclico, o heterociclilo monocíclico de entre 4 y 7 miembros, donde dichos cicloalquilo y heterociclilo están opcionalmente sustituidos con uno o más Rᵃ ; R² es C₁₋₄haloalquilo, fenilo, o C₃₋₆cicloalquilo monocíclico opcionalmente sustituido con uno o más Rᵇ; R³ es hidrógeno, C₁₋₄alquilo, o C₁₋₄haloalquilo; R⁴ es hidrógeno o C₁₋₄alquilo; R⁵ es halo; R⁶ es C₁₋₄alquilo o C₁₋₄haloalquilo, donde dichos C₁₋₄alquilo y C₁₋₄haloalquilo están sustituidos en cada caso con ORᶜ; t es 0, 1, ó 2; Rᵃ y Rᵇ se seleccionan en forma independiente entre sí entre halo, C₁₋₄alquilo, C₁₋₄haloalquilo, C₁₋₄alcoxi, y C₁₋₄haloalcoxi, Rᶜ es C₁₋₄alquilo opcionalmente sustituido con C₃₋₆cicloalquilo o C₁₋₄alcoxi, o C₃₋₆cicloalquilo; y Rᵈ es hidrógeno o C₁₋₄alquilo; con la condición de que el compuesto no es un compuesto que tiene la fórmula (3) ó (4); o una sal farmacéuticamente aceptable del mismo.Claim 1: A compound having the formula (1), or a pharmaceutically acceptable salt thereof, where X and Y are independently CRᵈ or N; R¹ is a moiety of formula (2), monocyclic C₃₋₆cycloalkyl, or 4- to 7-membered monocyclic heterocyclyl, wherein said cycloalkyl and heterocyclyl are optionally substituted with one or more Rᵃ; R² is C₁₋₄haloalkyl, phenyl, or monocyclic C₃₋₆cycloalkyl optionally substituted with one or more Rᵇ; R³ is hydrogen, C₁₋₄alkyl, or C₁₋₄haloalkyl; R⁴ is hydrogen or C₁₋₄alkyl; R⁵ is halo; R⁶ is C₁₋₄alkyl or C₁₋₄haloalkyl, wherein said C₁₋₄alkyl and C₁₋₄haloalkyl are substituted in each case with ORᶜ; t is 0, 1, or 2; Rᵃ and Rᵇ are independently selected from each other from halo, C₁₋₄alkyl, C₁₋₄haloalkyl, C₁₋₄alkoxy, and C₁₋₄haloalkoxy, Rᶜ is C₁₋₄alkyl optionally substituted with C₃₋₆cycloalkyl or C₁₋₄alkoxy, or C₃₋₆cycloalkyl ; and Rᵈ is hydrogen or C₁₋₄alkyl; provided that the compound is not a compound having the formula (3) or (4); or a pharmaceutically acceptable salt thereof.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862677903P | 2018-05-30 | 2018-05-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR115458A1 true AR115458A1 (en) | 2021-01-20 |
Family
ID=74446287
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP190101471A AR115458A1 (en) | 2018-05-30 | 2019-05-30 | ION CHANNEL MODULATORS |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR115458A1 (en) |
-
2019
- 2019-05-30 AR ARP190101471A patent/AR115458A1/en unknown
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