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Publication of AR114282A1publicationCriticalpatent/AR114282A1/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
Se proporcionan inhibidores de la secreción de proteínas basados en triazaciclododecansulfonamida (“TCD”), tales como inhibidores de Sec61, métodos para su preparación, composiciones farmacéuticas relacionadas y métodos para usar los mismos, Por ejemplo, aquí se proporcionan compuestos de fórmula (1), y sales y composiciones farmacéuticamente aceptables que incluyen las mismas. Los compuestos descritos aquí pueden usarse, por ejemplo. en el tratamiento de enfermedades que incluyen inflamación y/o cáncer.Provided are inhibitors of protein secretion based on triazacyclododecanesulfonamide ("TCD"), such as inhibitors of Sec61, methods for their preparation, related pharmaceutical compositions and methods for using the same. For example, compounds of formula (1) are provided herein , and pharmaceutically acceptable salts and compositions including the same. The compounds described herein can be used, for example. in the treatment of diseases including inflammation and / or cancer.
ARP190100662A2018-03-162019-03-15
PROTEIN SECRETION INHIBITORS BASED ON TRIAZACICLODODECANSULFONAMIDE ("TCD")
AR114282A1
(en)