AR112838A1 - TAM INHIBITOR SALTS - Google Patents

TAM INHIBITOR SALTS

Info

Publication number
AR112838A1
AR112838A1 ARP180102760A ARP180102760A AR112838A1 AR 112838 A1 AR112838 A1 AR 112838A1 AR P180102760 A ARP180102760 A AR P180102760A AR P180102760 A ARP180102760 A AR P180102760A AR 112838 A1 AR112838 A1 AR 112838A1
Authority
AR
Argentina
Prior art keywords
phenyl
salt
isobutyrylpiperidin
tetrahydropyrimidine
triazin
Prior art date
Application number
ARP180102760A
Other languages
Spanish (es)
Inventor
Qun Li
Jiacheng Zhou
Yongchun Pan
Yongzhong Wu
Zhongjiang Jia
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of AR112838A1 publication Critical patent/AR112838A1/en

Links

Abstract

La presente solicitud proporciona formas de sal de N-(4-(4-amino-7-(1-isobutirilpiperidin-4-il)pirrolo[1,2-f][1,2,4]triazin-5-il)fenil)-1-isopropil-2,4-dioxo-3-(piridin-2-il)-1,2,3,4-tetrahidropirimidina-5-carboxamida y N-(4-(4-amino-7-(1-isobutirilpiperidin-4-il)pirrolo[1,2-f][1,2,4]triazin-5-il)fenil)-1-isopropil-2,4-dioxo-3-fenil-1,2,3,4-tetrahidropirimidina-5-carboxamida, que son útiles como inhibidores de cinasas TAM, así como procesos e intermedios relacionados con estas. Reivindicación 1: Una sal que es sal de ácido maleico de N-(4-(4-amino-7-(1-isobutirilpiperidin-4-il)pirrolo[1,2-f][1,2,4]triazin-5-il)fenil)-1-isopropil-2,4-dioxo-3-(piridin-2-il)-1,2,3,4-tetrahidropirimidina-5-carboxamida. Reivindicación 8: La sal de la reivindicación 1, que tiene al menos un pico de XRPD, en términos de 2-q, que se selecciona de alrededor de 4.3º, alrededor de 8.4º, alrededor de 12.6º, alrededor de 13.2º, y alrededor de 18.5º. Reivindicación 14: Una sal que es ácido hemi-sulfúrico de N-(4-(4-amino-7-(1-isobutirilpiperidin-4-il)pirrolo[1,2-f][1,2,4]triazin-5-i)fenil)-1-isopropil-2,4-dioxo-3-fenil-1,2,3,4-tetrahidropirimidina-5-carboxamida. Reivindicación 21: La sal de la reivindicación 14, que tiene al menos un pico de XRPD, en términos de 2-qtheta, que se selecciona de alrededor de 5.3º, alrededor de 8.5º, alrededor de 15.3º, alrededor de 20.1º, y alrededor de 24.9º.The present application provides salt forms of N- (4- (4-amino-7- (1-isobutyrylpiperidin-4-yl) pyrrolo [1,2-f] [1,2,4] triazin-5-yl) phenyl) -1-isopropyl-2,4-dioxo-3- (pyridin-2-yl) -1,2,3,4-tetrahydropyrimidine-5-carboxamide and N- (4- (4-amino-7- ( 1-isobutyrylpiperidin-4-yl) pyrrolo [1,2-f] [1,2,4] triazin-5-yl) phenyl) -1-isopropyl-2,4-dioxo-3-phenyl-1,2, 3,4-tetrahydropyrimidine-5-carboxamide, which are useful as inhibitors of TAM kinases, as well as related processes and intermediates. Claim 1: A salt which is the maleic acid salt of N- (4- (4-amino-7- (1-isobutyrylpiperidin-4-yl) pyrrolo [1,2-f] [1,2,4] triazin- 5-yl) phenyl) -1-isopropyl-2,4-dioxo-3- (pyridin-2-yl) -1,2,3,4-tetrahydropyrimidine-5-carboxamide. Claim 8: The salt of claim 1, having at least one XRPD peak, in terms of 2-q, which is selected from about 4.3 °, about 8.4 °, about 12.6 °, about 13.2 °, and around 18.5º. Claim 14: A salt which is hemi-sulfuric acid of N- (4- (4-amino-7- (1-isobutyrylpiperidin-4-yl) pyrrolo [1,2-f] [1,2,4] triazin- 5-i) phenyl) -1-isopropyl-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxamide. Claim 21: The salt of claim 14, having at least one XRPD peak, in terms of 2-qtheta, which is selected from about 5.3 °, about 8.5 °, about 15.3 °, about 20.1 °, and around 24.9º.

ARP180102760A 2017-09-27 2018-09-26 TAM INHIBITOR SALTS AR112838A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762564070P 2017-09-27 2017-09-27

Publications (1)

Publication Number Publication Date
AR112838A1 true AR112838A1 (en) 2019-12-18

Family

ID=69024801

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP180102760A AR112838A1 (en) 2017-09-27 2018-09-26 TAM INHIBITOR SALTS

Country Status (2)

Country Link
AR (1) AR112838A1 (en)
HR (1) HRP20211995T1 (en)

Also Published As

Publication number Publication date
HRP20211995T1 (en) 2022-04-01

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