AR112838A1 - TAM INHIBITOR SALTS - Google Patents
TAM INHIBITOR SALTSInfo
- Publication number
- AR112838A1 AR112838A1 ARP180102760A ARP180102760A AR112838A1 AR 112838 A1 AR112838 A1 AR 112838A1 AR P180102760 A ARP180102760 A AR P180102760A AR P180102760 A ARP180102760 A AR P180102760A AR 112838 A1 AR112838 A1 AR 112838A1
- Authority
- AR
- Argentina
- Prior art keywords
- phenyl
- salt
- isobutyrylpiperidin
- tetrahydropyrimidine
- triazin
- Prior art date
Links
Abstract
La presente solicitud proporciona formas de sal de N-(4-(4-amino-7-(1-isobutirilpiperidin-4-il)pirrolo[1,2-f][1,2,4]triazin-5-il)fenil)-1-isopropil-2,4-dioxo-3-(piridin-2-il)-1,2,3,4-tetrahidropirimidina-5-carboxamida y N-(4-(4-amino-7-(1-isobutirilpiperidin-4-il)pirrolo[1,2-f][1,2,4]triazin-5-il)fenil)-1-isopropil-2,4-dioxo-3-fenil-1,2,3,4-tetrahidropirimidina-5-carboxamida, que son útiles como inhibidores de cinasas TAM, así como procesos e intermedios relacionados con estas. Reivindicación 1: Una sal que es sal de ácido maleico de N-(4-(4-amino-7-(1-isobutirilpiperidin-4-il)pirrolo[1,2-f][1,2,4]triazin-5-il)fenil)-1-isopropil-2,4-dioxo-3-(piridin-2-il)-1,2,3,4-tetrahidropirimidina-5-carboxamida. Reivindicación 8: La sal de la reivindicación 1, que tiene al menos un pico de XRPD, en términos de 2-q, que se selecciona de alrededor de 4.3º, alrededor de 8.4º, alrededor de 12.6º, alrededor de 13.2º, y alrededor de 18.5º. Reivindicación 14: Una sal que es ácido hemi-sulfúrico de N-(4-(4-amino-7-(1-isobutirilpiperidin-4-il)pirrolo[1,2-f][1,2,4]triazin-5-i)fenil)-1-isopropil-2,4-dioxo-3-fenil-1,2,3,4-tetrahidropirimidina-5-carboxamida. Reivindicación 21: La sal de la reivindicación 14, que tiene al menos un pico de XRPD, en términos de 2-qtheta, que se selecciona de alrededor de 5.3º, alrededor de 8.5º, alrededor de 15.3º, alrededor de 20.1º, y alrededor de 24.9º.The present application provides salt forms of N- (4- (4-amino-7- (1-isobutyrylpiperidin-4-yl) pyrrolo [1,2-f] [1,2,4] triazin-5-yl) phenyl) -1-isopropyl-2,4-dioxo-3- (pyridin-2-yl) -1,2,3,4-tetrahydropyrimidine-5-carboxamide and N- (4- (4-amino-7- ( 1-isobutyrylpiperidin-4-yl) pyrrolo [1,2-f] [1,2,4] triazin-5-yl) phenyl) -1-isopropyl-2,4-dioxo-3-phenyl-1,2, 3,4-tetrahydropyrimidine-5-carboxamide, which are useful as inhibitors of TAM kinases, as well as related processes and intermediates. Claim 1: A salt which is the maleic acid salt of N- (4- (4-amino-7- (1-isobutyrylpiperidin-4-yl) pyrrolo [1,2-f] [1,2,4] triazin- 5-yl) phenyl) -1-isopropyl-2,4-dioxo-3- (pyridin-2-yl) -1,2,3,4-tetrahydropyrimidine-5-carboxamide. Claim 8: The salt of claim 1, having at least one XRPD peak, in terms of 2-q, which is selected from about 4.3 °, about 8.4 °, about 12.6 °, about 13.2 °, and around 18.5º. Claim 14: A salt which is hemi-sulfuric acid of N- (4- (4-amino-7- (1-isobutyrylpiperidin-4-yl) pyrrolo [1,2-f] [1,2,4] triazin- 5-i) phenyl) -1-isopropyl-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxamide. Claim 21: The salt of claim 14, having at least one XRPD peak, in terms of 2-qtheta, which is selected from about 5.3 °, about 8.5 °, about 15.3 °, about 20.1 °, and around 24.9º.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762564070P | 2017-09-27 | 2017-09-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR112838A1 true AR112838A1 (en) | 2019-12-18 |
Family
ID=69024801
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP180102760A AR112838A1 (en) | 2017-09-27 | 2018-09-26 | TAM INHIBITOR SALTS |
Country Status (2)
Country | Link |
---|---|
AR (1) | AR112838A1 (en) |
HR (1) | HRP20211995T1 (en) |
-
2018
- 2018-09-26 HR HRP20211995TT patent/HRP20211995T1/en unknown
- 2018-09-26 AR ARP180102760A patent/AR112838A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
HRP20211995T1 (en) | 2022-04-01 |
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