AR110675A1 - MODIFIED OLIGONUCLEOTIDES AND METHODS OF USE - Google Patents

MODIFIED OLIGONUCLEOTIDES AND METHODS OF USE

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Publication number
AR110675A1
AR110675A1 ARP170102544A ARP170102544A AR110675A1 AR 110675 A1 AR110675 A1 AR 110675A1 AR P170102544 A ARP170102544 A AR P170102544A AR P170102544 A ARP170102544 A AR P170102544A AR 110675 A1 AR110675 A1 AR 110675A1
Authority
AR
Argentina
Prior art keywords
oligonucleotide
methods
modified oligonucleotides
cell
nucleobase
Prior art date
Application number
ARP170102544A
Other languages
Spanish (es)
Original Assignee
Alios Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alios Biopharma Inc filed Critical Alios Biopharma Inc
Publication of AR110675A1 publication Critical patent/AR110675A1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se describen oligonucleótidos modificados que comprenden modificaciones en las posiciones 2’ y/o 3’ en conjunto con métodos para laborarlas y usos, por ejemplo, contra HBV. Reivindicación 1: Un oligonucleótido que comprende uno o más nucleótidos de la fórmula (1), en donde R es H o un contraión con carga positiva; B es una nucleobase; R¹ es -(CR’₂)₂OCR’₃; y R’ es independientemente en cada caso H o F. Reivindicación 104: Un método para inhibir la replicación de un virus en una célula; el método comprende poner en contacto la célula con un oligonucleótido o con una composición que comprende el oligonucleótido de cualquiera de las reivindicaciones 1 a 97, en donde el oligonucleótido contiene una secuencia de nucleobases que es complementaria o se híbrida con una porción de un ARN objetivo viral.Modified oligonucleotides are described which comprise modifications in the 2 ’and / or 3’ positions in conjunction with methods for working them and uses, for example, against HBV. Claim 1: An oligonucleotide comprising one or more nucleotides of the formula (1), wherein R is H or a positively charged counterion; B is a nucleobase; R¹ is - (CR’₂) ₂OCR’₃; and R ’is independently in each case H or F. Claim 104: A method of inhibiting the replication of a virus in a cell; The method comprises contacting the cell with an oligonucleotide or with a composition comprising the oligonucleotide of any one of claims 1 to 97, wherein the oligonucleotide contains a nucleobase sequence that is complementary or hybridizes with a portion of a target RNA. viral.

ARP170102544A 2016-09-14 2017-09-14 MODIFIED OLIGONUCLEOTIDES AND METHODS OF USE AR110675A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662394738P 2016-09-14 2016-09-14

Publications (1)

Publication Number Publication Date
AR110675A1 true AR110675A1 (en) 2019-04-24

Family

ID=66326296

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP170102544A AR110675A1 (en) 2016-09-14 2017-09-14 MODIFIED OLIGONUCLEOTIDES AND METHODS OF USE

Country Status (1)

Country Link
AR (1) AR110675A1 (en)

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