AR109976A1 - OXIESTEROLS AND METHODS FOR USE - Google Patents
OXIESTEROLS AND METHODS FOR USEInfo
- Publication number
- AR109976A1 AR109976A1 ARP170102897A ARP170102897A AR109976A1 AR 109976 A1 AR109976 A1 AR 109976A1 AR P170102897 A ARP170102897 A AR P170102897A AR P170102897 A ARP170102897 A AR P170102897A AR 109976 A1 AR109976 A1 AR 109976A1
- Authority
- AR
- Argentina
- Prior art keywords
- hydrogen
- alkyl
- double bond
- carbocyclyl
- heterocyclyl
- Prior art date
Links
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Los compuestos de la presente están contemplados como útiles para la prevención y tratamiento de trastornos mediados por NMDA. Reivindicación 1: Un compuesto caracterizado porque es de fórmula (1), o una sal farmacéuticamente aceptable del mismo, en donde: R¹ es alquilo; R² es hidrógeno, alquilo, carbociclilo, heterociclilo, arilo, o heteroarilo y R³ es alquilo, carbociclilo, heterociclilo, arilo, o heteroarilo, o R² y R³, junto con el átomo de carbono al cual están unidos forman un anillo de entre 3 y 8 miembros; cada uno de R⁴ y R⁵ es independientemente hidrógeno, halo, o -ORC, en donde RC es hidrógeno o C₁₋₆ alquilo, o R⁴ R⁵, junto con el átomo de carbono al cual están unidos forman un grupo oxo; R⁶ está ausente o es hidrógeno; y ⁻ ⁻ ⁻ ⁻ ⁻ representa un enlace simple o doble, en donde cuando uno de los ⁻ ⁻ ⁻ ⁻ ⁻ es un doble enlace, el otro ⁻ ⁻ ⁻ ⁻ ⁻ es un enlace simple; cuando ambos de los ⁻ ⁻ ⁻ ⁻ ⁻ son enlaces simples, entonces R⁶ es hidrógeno; y cuando uno de los ⁻ ⁻ ⁻ ⁻ ⁻ es un doble enlace, R⁶ está ausente.The compounds herein are contemplated as useful for the prevention and treatment of NMDA-mediated disorders. Claim 1: A compound characterized in that it is of formula (1), or a pharmaceutically acceptable salt thereof, wherein: R¹ is alkyl; R² is hydrogen, alkyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl and R³ is alkyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl, or R² and R³, together with the carbon atom to which they are attached form a ring of between 3 and 8 members; each of R⁴ and R⁵ is independently hydrogen, halo, or -ORC, where RC is hydrogen or C₁₋₆ alkyl, or R⁴ R⁵, together with the carbon atom to which they are attached form an oxo group; R⁶ is absent or is hydrogen; and ⁻ ⁻ ⁻ ⁻ ⁻ represents a single or double bond, where when one of the ⁻ ⁻ ⁻ ⁻ ⁻ is a double bond, the other ⁻ ⁻ ⁻ ⁻ ⁻ is a single bond; when both of the ⁻ ⁻ ⁻ ⁻ ⁻ are simple bonds, then R⁶ is hydrogen; and when one of the ⁻ ⁻ ⁻ ⁻ ⁻ is a double bond, R⁶ is absent.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662409756P | 2016-10-18 | 2016-10-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR109976A1 true AR109976A1 (en) | 2019-02-13 |
Family
ID=65728655
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP170102897A AR109976A1 (en) | 2016-10-18 | 2017-10-18 | OXIESTEROLS AND METHODS FOR USE |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR109976A1 (en) |
-
2017
- 2017-10-18 AR ARP170102897A patent/AR109976A1/en unknown
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