AR109951A1 - INDAZOL COMPOUNDS WITH ANTITUMOR PROPERTIES - Google Patents
INDAZOL COMPOUNDS WITH ANTITUMOR PROPERTIESInfo
- Publication number
- AR109951A1 AR109951A1 ARP170102869A ARP170102869A AR109951A1 AR 109951 A1 AR109951 A1 AR 109951A1 AR P170102869 A ARP170102869 A AR P170102869A AR P170102869 A ARP170102869 A AR P170102869A AR 109951 A1 AR109951 A1 AR 109951A1
- Authority
- AR
- Argentina
- Prior art keywords
- ch2f
- chf2
- compounds
- ome
- pharmaceutically acceptable
- Prior art date
Links
Abstract
Se relaciona con compuestos y con las sales de los mismos aceptables desde el punto de vista farmacéutico, con los procesos y productos intermedios que se utilizan para su preparación, con las composiciones farmacéuticas que los contienen así como con su uso en el tratamiento de los trastornos proliferativos de las células. Reivindicación 1: Un compuesto de la fórmula (1), caracterizado porque: A es CR² o N; G es CR³ o N; D es CR⁴ o N; E es CR⁵ o N; Q es O, NH o NMe; R¹ es CH₂F, CHF₂ o CF₃; R² es H, F, Cl, Me, CN, OMe o OEt; R³ es H o F; R⁴ es H, F, CN u OMe; R⁵ es H o F; R⁶ es H, Me, CH₂F, CHF₂ o CF₃; R⁷ es H o Me; R⁸ es alquilo C₁₋₃, CH₂F, CHF₂, CF₃ o cicloalquilo C₃₋₄; R⁹ es Me, F o CH₂F; R¹⁰ es Me, F, CH₂F, CHF₂, CF₃, CH₂OMe o CH₂OH; R¹¹ es H o F; o R¹⁰ y R¹¹ tomados junto con el átomo de carbono al cual ellos están enlazados forman un anillo de ciclopropilo o un anillo de oxetano; R¹² es independientemente seleccionado de F o Me; R¹³ es H o F; y a es 0, 1 ó 2; o una sal del mismo aceptable desde el punto de vista farmacéutico.It relates to compounds and the pharmaceutically acceptable salts thereof, with the processes and intermediates that are used for their preparation, with the pharmaceutical compositions that contain them as well as with their use in the treatment of disorders. proliferative cells. Claim 1: A compound of the formula (1), characterized in that: A is CR² or N; G is CR³ or N; D is CR⁴ or N; E is CR⁵ or N; Q is O, NH or NMe; R¹ is CH₂F, CHF₂ or CF₃; R² is H, F, Cl, Me, CN, OMe or OEt; R³ is H or F; R⁴ is H, F, CN or OMe; R⁵ is H or F; R⁶ is H, Me, CH₂F, CHF₂ or CF₃; R⁷ is H or Me; R⁸ is C₁₋₃ alkyl, CH₂F, CHF₂, CF₃ or C₃₋₄ cycloalkyl; R⁹ is Me, F or CH₂F; R¹⁰ is Me, F, CH₂F, CHF₂, CF₃, CH₂OMe or CH₂OH; R¹¹ is H or F; or R¹⁰ and R¹¹ taken together with the carbon atom to which they are attached form a cyclopropyl ring or an oxetane ring; R¹² is independently selected from F or Me; R¹³ is H or F; and a is 0, 1 or 2; or a pharmaceutically acceptable salt thereof.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662411799P | 2016-10-24 | 2016-10-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR109951A1 true AR109951A1 (en) | 2019-02-06 |
Family
ID=65728648
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP170102869A AR109951A1 (en) | 2016-10-24 | 2017-10-13 | INDAZOL COMPOUNDS WITH ANTITUMOR PROPERTIES |
Country Status (3)
Country | Link |
---|---|
AR (1) | AR109951A1 (en) |
HR (1) | HRP20191812T1 (en) |
RS (1) | RS62937B1 (en) |
-
2017
- 2017-10-13 RS RS20220170A patent/RS62937B1/en unknown
- 2017-10-13 AR ARP170102869A patent/AR109951A1/en unknown
-
2019
- 2019-10-04 HR HRP20191812TT patent/HRP20191812T1/en unknown
Also Published As
Publication number | Publication date |
---|---|
HRP20191812T1 (en) | 2019-12-27 |
RS62937B1 (en) | 2022-03-31 |
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