AR108975A1 - ANTIBODIES WITH LOW IMMUNOGENICITY AND ITS USES - Google Patents
ANTIBODIES WITH LOW IMMUNOGENICITY AND ITS USESInfo
- Publication number
- AR108975A1 AR108975A1 ARP170101865A ARP170101865A AR108975A1 AR 108975 A1 AR108975 A1 AR 108975A1 AR P170101865 A ARP170101865 A AR P170101865A AR P170101865 A ARP170101865 A AR P170101865A AR 108975 A1 AR108975 A1 AR 108975A1
- Authority
- AR
- Argentina
- Prior art keywords
- antibodies
- low immunogenicity
- immunogenicity
- methods
- binding fragments
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
- C07K16/465—Igs containing CDR-residues from one specie grafted between FR-residues from another with additional modified FR-residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
Anticuerpos y fragmentos de fijación al antígeno de estos con baja inmunogenicidad o sin inmunogenicidad en seres humanos y, opcionalmente, con propiedades de fabricación deseadas. También composiciones que comprenden tales anticuerpos o fragmentos de fijación al antígeno, métodos para usar tales anticuerpos y métodos para fabricar tales anticuerpos.Antibodies and antigen-binding fragments thereof with low immunogenicity or no immunogenicity in humans and, optionally, with desired manufacturing properties. Also compositions comprising such antibodies or antigen binding fragments, methods for using such antibodies and methods for making such antibodies.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662359150P | 2016-07-06 | 2016-07-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR108975A1 true AR108975A1 (en) | 2018-10-17 |
Family
ID=60913146
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP170101865A AR108975A1 (en) | 2016-07-06 | 2017-07-05 | ANTIBODIES WITH LOW IMMUNOGENICITY AND ITS USES |
Country Status (19)
Country | Link |
---|---|
US (1) | US11427632B2 (en) |
EP (1) | EP3481862A4 (en) |
JP (1) | JP7120989B2 (en) |
KR (1) | KR20190035737A (en) |
CN (1) | CN109689684B (en) |
AR (1) | AR108975A1 (en) |
AU (1) | AU2017292752B2 (en) |
BR (1) | BR112019000166A2 (en) |
CA (1) | CA3029977A1 (en) |
CL (1) | CL2019000019A1 (en) |
CO (1) | CO2019001112A2 (en) |
EA (1) | EA201990218A1 (en) |
EC (1) | ECSP19008417A (en) |
IL (1) | IL264009A (en) |
MX (1) | MX2019000172A (en) |
SG (1) | SG11201811788SA (en) |
TW (1) | TW201811824A (en) |
WO (1) | WO2018009499A1 (en) |
ZA (1) | ZA201900070B (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112020001679A2 (en) | 2017-08-02 | 2020-07-21 | Phanes Therapeutics, Inc. | anti-cd47 antibodies and their uses |
KR102115300B1 (en) * | 2018-06-01 | 2020-05-26 | 재단법인 목암생명과학연구소 | Antibody library and Screening Method of Antibody by Using the Same |
TW202104260A (en) | 2019-04-05 | 2021-02-01 | 美商西建公司 | Engineering of an antibody for tumor-selective binding of cd47 |
JP2022535286A (en) | 2019-06-07 | 2022-08-05 | エーエルエックス オンコロジー インコーポレイテッド | Methods and reagents for reducing interference of drugs that bind CD47 in serological assays |
JP2023545983A (en) | 2020-10-07 | 2023-11-01 | セルジーン コーポレイション | Bispecific antibody therapy for lymphoid malignancy conditions |
JP2023552375A (en) | 2020-12-06 | 2023-12-15 | エーエルエックス オンコロジー インコーポレイテッド | Multimers for reducing interference of drugs that bind to CD47 in serological assays |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL91501A (en) | 1988-09-02 | 1998-03-10 | Dyax Corp | Generation of a variegated library of mutant potential binding proteins and screening of said library for proteins with a desired binding activity |
AU7247191A (en) | 1990-01-11 | 1991-08-05 | Molecular Affinities Corporation | Production of antibodies using gene libraries |
GB9026912D0 (en) | 1990-12-11 | 1991-01-30 | Wessex Instrumentation Limited | Reaction detection equipment |
AU662148B2 (en) | 1991-04-10 | 1995-08-24 | Scripps Research Institute, The | Heterodimeric receptor libraries using phagemids |
JPH07503124A (en) | 1991-06-14 | 1995-04-06 | ゾーマ・コーポレーション | Antibody fragments and their complexes produced by microorganisms |
IE922437A1 (en) | 1991-07-25 | 1993-01-27 | Idec Pharma Corp | Recombinant antibodies for human therapy |
ES2227512T3 (en) | 1991-12-02 | 2005-04-01 | Medical Research Council | PRODUCTION OF ANTIBODIES AGAINST SELF-ANTIGENS FROM REPERTORIES OF ANTIBODY SEGMENTS FIXED IN A PHOTO. |
DE69621940T2 (en) * | 1995-08-18 | 2003-01-16 | Morphosys Ag | PROTEIN - / (POLY) PEPTIDE LIBRARIES |
US7321026B2 (en) * | 2001-06-27 | 2008-01-22 | Skytech Technology Limited | Framework-patched immunoglobulins |
MXPA05000511A (en) | 2001-07-12 | 2005-09-30 | Jefferson Foote | Super humanized antibodies. |
KR20120035234A (en) * | 2003-04-11 | 2012-04-13 | 메디뮨 엘엘씨 | Recombinant il-9 antibodies and uses thereof |
US20060228350A1 (en) | 2003-08-18 | 2006-10-12 | Medimmune, Inc. | Framework-shuffling of antibodies |
CN100453556C (en) | 2003-10-16 | 2009-01-21 | 麦克罗梅特股份公司 | Multispecific deimmunized CD3-binders |
US7354854B2 (en) | 2005-05-24 | 2008-04-08 | Texas Instruments Incorporated | Nickel silicide method and structure |
BRPI0610912A2 (en) * | 2005-06-01 | 2008-12-02 | Micromet Ag | anti-il2 antibodies |
AU2007245181A1 (en) | 2006-03-30 | 2007-11-08 | Novartis Ag | Compositions and methods of use for antibodies of c-Met |
CA2832111A1 (en) | 2006-12-20 | 2008-07-03 | Mmrglobal, Inc. | Antibodies and methods for making and using them |
EP2014681A1 (en) * | 2007-07-12 | 2009-01-14 | Pierre Fabre Medicament | Novel antibodies inhibiting c-met dimerization, and uses thereof |
MX352871B (en) | 2009-12-23 | 2017-12-13 | Esbatech Alcon Biomed Res Unit | Method for decreasing immunogenicity. |
JP5992340B2 (en) * | 2010-02-18 | 2016-09-14 | エフィミュヌEffimune | Anti-CD28 humanized antibody |
US9045541B2 (en) * | 2012-02-06 | 2015-06-02 | Inhibrx Llc | CD47 antibodies and methods of use thereof |
EP2859017B1 (en) | 2012-06-08 | 2019-02-20 | Sutro Biopharma, Inc. | Antibodies comprising site-specific non-natural amino acid residues, methods of their preparation and methods of their use |
SG11201501464TA (en) | 2012-08-31 | 2015-03-30 | Sutro Biopharma Inc | Modified amino acids comprising an azido group |
KR102170196B1 (en) | 2013-02-06 | 2020-10-26 | 인히브릭스, 인크. | Non-platelet depleting and non-red blood cell depleting cd47 antibodies and methods of use thereof |
WO2016073906A2 (en) | 2014-11-06 | 2016-05-12 | Scholar Rock, Inc. | Transforming growth factor-related immunoassays |
BR112017010303A2 (en) | 2014-11-18 | 2018-05-15 | Janssen Pharmaceutica Nv | cd47 antibodies, methods and uses |
KR102489471B1 (en) * | 2014-12-30 | 2023-01-18 | 셀진 코포레이션 | Anti-CD47 Antibodies and Uses Thereof |
JP2018535692A (en) * | 2015-09-21 | 2018-12-06 | エラスムス ユニバーシティ メディカル センターErasmus University Medical Center | Anti-CD47 antibody and method of use |
-
2017
- 2017-07-05 EA EA201990218A patent/EA201990218A1/en unknown
- 2017-07-05 WO PCT/US2017/040653 patent/WO2018009499A1/en unknown
- 2017-07-05 AU AU2017292752A patent/AU2017292752B2/en not_active Expired - Fee Related
- 2017-07-05 AR ARP170101865A patent/AR108975A1/en unknown
- 2017-07-05 CA CA3029977A patent/CA3029977A1/en active Pending
- 2017-07-05 TW TW106122515A patent/TW201811824A/en unknown
- 2017-07-05 KR KR1020197003635A patent/KR20190035737A/en not_active Application Discontinuation
- 2017-07-05 BR BR112019000166A patent/BR112019000166A2/en not_active Application Discontinuation
- 2017-07-05 SG SG11201811788SA patent/SG11201811788SA/en unknown
- 2017-07-05 CN CN201780054156.XA patent/CN109689684B/en active Active
- 2017-07-05 JP JP2019500244A patent/JP7120989B2/en active Active
- 2017-07-05 MX MX2019000172A patent/MX2019000172A/en unknown
- 2017-07-05 EP EP17824773.0A patent/EP3481862A4/en active Pending
- 2017-07-05 US US16/315,141 patent/US11427632B2/en active Active
-
2018
- 2018-12-28 IL IL264009A patent/IL264009A/en unknown
-
2019
- 2019-01-04 CL CL2019000019A patent/CL2019000019A1/en unknown
- 2019-01-04 ZA ZA2019/00070A patent/ZA201900070B/en unknown
- 2019-02-05 EC ECSENADI20198417A patent/ECSP19008417A/en unknown
- 2019-02-05 CO CONC2019/0001112A patent/CO2019001112A2/en unknown
Also Published As
Publication number | Publication date |
---|---|
ECSP19008417A (en) | 2019-02-28 |
JP7120989B2 (en) | 2022-08-17 |
US11427632B2 (en) | 2022-08-30 |
WO2018009499A1 (en) | 2018-01-11 |
CN109689684A (en) | 2019-04-26 |
AU2017292752B2 (en) | 2023-07-27 |
MX2019000172A (en) | 2019-09-26 |
BR112019000166A2 (en) | 2019-10-01 |
CA3029977A1 (en) | 2018-01-11 |
AU2017292752A1 (en) | 2019-01-24 |
IL264009A (en) | 2019-01-31 |
CL2019000019A1 (en) | 2019-06-28 |
KR20190035737A (en) | 2019-04-03 |
EA201990218A1 (en) | 2019-07-31 |
JP2019524087A (en) | 2019-09-05 |
US20190241654A1 (en) | 2019-08-08 |
CN109689684B (en) | 2022-09-23 |
EP3481862A4 (en) | 2020-08-12 |
CO2019001112A2 (en) | 2019-02-19 |
EP3481862A1 (en) | 2019-05-15 |
TW201811824A (en) | 2018-04-01 |
SG11201811788SA (en) | 2019-01-30 |
ZA201900070B (en) | 2023-08-30 |
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