AR106560A1 - A PRODUCT TO PREVENT OR TREAT A BREASTHOOD IN A NON-HUMAN ANIMAL - Google Patents

A PRODUCT TO PREVENT OR TREAT A BREASTHOOD IN A NON-HUMAN ANIMAL

Info

Publication number
AR106560A1
AR106560A1 ARP160103345A ARP160103345A AR106560A1 AR 106560 A1 AR106560 A1 AR 106560A1 AR P160103345 A ARP160103345 A AR P160103345A AR P160103345 A ARP160103345 A AR P160103345A AR 106560 A1 AR106560 A1 AR 106560A1
Authority
AR
Argentina
Prior art keywords
sol
product according
nipple
gel
clay
Prior art date
Application number
ARP160103345A
Other languages
Spanish (es)
Inventor
A Sanders Tammy
Luo Laibin
L Secreast Stephen
L Huczek Dennis
R Quesnell Rebecca
A Zook Christopher
Kujawa Piotr
Baille Wilms
Rajagopalan Sumitra
Original Assignee
Zoetis Services Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zoetis Services Llc filed Critical Zoetis Services Llc
Publication of AR106560A1 publication Critical patent/AR106560A1/en

Links

Abstract

Compuestos poliméricos sol-gel que comprenden quitosano, un polímero hidrófilo, un agente de gelificación e ingredientes adicionales opcionales en un medio adecuado. El compuesto polimérico sol-gel puede formar un sello duradero o un sólido fuerte en respuesta a uno o más estímulos fisiológicos. Usos médicos y veterinarios del compuesto, en particular, métodos y sistemas de administración para reducir o prevenir la incidencia de un trastorno mamario en un animal lechero. Más en particular, métodos y composiciones de compuestos poliméricos sol-gel para crear una barrera física en la superficie del pezón o en el canal o la cisterna del pezón de un animal no humano para el tratamiento profiláctico de trastornos mamarios, tales como mastitis, en donde el polímero sol-gel crea un sello en respuesta a uno o más estímulos fisiológicos. Reivindicación 1: Un producto para prevenir o tratar un trastorno mamario en un animal no humano hembra, caracterizado porque comprende una cantidad eficaz de un compuesto polimérico sol-gel. Reivindicación 3: El producto de acuerdo con la reivindicación 2, caracterizado porque el medio es ácido acético acuoso. Reivindicación 5: El producto de acuerdo con la reivindicación 4, caracterizado porque el quitosano acilado es quitosano de carboximetilo. Reivindicación 7: El producto de acuerdo con la reivindicación 2, caracterizado porque el polímero hidrófilo se selecciona del grupo que consiste en metilcelulosa, polivinilacetato, polivinilacetato-acilato, hidroxipropilcelulosa, etilhidroxietilcelulosa, ácido hialurónico, copolímero en tres bloques no iónico, polietilenglicol y alginato de sodio. Reivindicación 10: El producto de acuerdo con la reivindicación 2, caracterizado porque el agente de gelificación es una sal seleccionada del grupo que consiste en b-glicerofosfato de disodio hidrato, b-glicerofosfato de disodio pentahidrato, pirofosfato de sodio tetrabásico, fosfato de potasio dibásico trihidrato y una mezcla de estos. Reivindicación 12: El producto de acuerdo con la reivindicación 11, caracterizado porque el agente de refuerzo se selecciona del grupo que consiste en celulosa nanocristalina, una arcilla inorgánica, una arcilla orgánica, negro de carbón, sílice ahumada, grafeno, grafito, un almidón nanocristalino, una nanoarcilla, grafeno, un nanotubo de carbono, una nanoarcilla orgánica, una organoarcilla, montmorillonita, bentonita, caolinita, hectorita, haloisita y fosfato ole calcio. Reivindicación 14: El producto de acuerdo con la reivindicación 13, caracterizado porque el agente antimicrobiano se selecciona del grupo que consiste en un macrólido, una cefalosporina, un antibiótico de lincosaminida, una fluoroquinolona, una tetraciclina, una penicilina, una espectinomicina, una sulfonamida, un cloranfenicol, un análogo sintético fluorinado de tianfenicol y una mezcla de estos. Reivindicación 15: El producto de acuerdo con la reivindicación 14, caracterizado porque el agente antimicrobiano es una cefalosporina, y la cefalosporina es ceftiofur clorhidrato. Reivindicación 16: Un método para prevenir o tratar un trastorno mamario en un animal no humano hembra, caracterizado porque comprende administrar una cantidad eficaz de un compuesto polimérico sol-gel en un pezón, un canal del pezón o una cisterna del pezón del animal. Reivindicación 17: Un sistema para formar una barrera física en el canal o la cisterna del pezón de un animal no humano para la prevención o el tratamiento de un trastorno mamario, caracterizado porque el sistema comprende un dispositivo de administración que contiene un compuesto polimérico sol-gel. Reivindicación 18: El sistema de acuerdo con la reivindicación 17, caracterizado porque el dispositivo de administración es una jeringa.Sol-gel polymeric compounds comprising chitosan, a hydrophilic polymer, a gelling agent and optional additional ingredients in a suitable medium. The sol-gel polymeric compound may form a durable seal or a strong solid in response to one or more physiological stimuli. Medical and veterinary uses of the compound, in particular, methods and systems of administration to reduce or prevent the incidence of a breast disorder in a dairy animal. More particularly, methods and compositions of sol-gel polymeric compounds to create a physical barrier on the surface of the nipple or in the nipple canal or cistern of a non-human animal for the prophylactic treatment of breast disorders, such as mastitis, in where the sol-gel polymer creates a seal in response to one or more physiological stimuli. Claim 1: A product for preventing or treating a breast disorder in a female non-human animal, characterized in that it comprises an effective amount of a sol-gel polymeric compound. Claim 3: The product according to claim 2, characterized in that the medium is aqueous acetic acid. Claim 5: The product according to claim 4, characterized in that the acylated chitosan is carboxymethyl chitosan. Claim 7: The product according to claim 2, characterized in that the hydrophilic polymer is selected from the group consisting of methylcellulose, polyvinylacetate, polyvinylacetate-acylate, hydroxypropylcellulose, ethylhydroxyethylcellulose, hyaluronic acid, non-ionic three-block copolymer, polyethylene glycol and alginate sodium. Claim 10: The product according to claim 2, characterized in that the gelling agent is a salt selected from the group consisting of disodium hydrogen glyphophosphate, disodium pentahydrate b-glycerophosphate, tetrabasic sodium pyrophosphate, dibasic potassium phosphate trihydrate and a mixture of these. Claim 12: The product according to claim 11, characterized in that the reinforcing agent is selected from the group consisting of nanocrystalline cellulose, an inorganic clay, an organic clay, carbon black, smoked silica, graphene, graphite, a nanocrystalline starch , a nano-clay, graphene, a carbon nanotube, an organic nano-clay, an organo-clay, montmorillonite, bentonite, kaolinite, hectorite, haloisite and phosphate ole calcium. Claim 14: The product according to claim 13, characterized in that the antimicrobial agent is selected from the group consisting of a macrolide, a cephalosporin, a lincosaminide antibiotic, a fluoroquinolone, a tetracycline, a penicillin, a spectinomycin, a sulfonamide, a chloramphenicol, a fluorinated synthetic analog of thiamphenicol and a mixture of these. Claim 15: The product according to claim 14, characterized in that the antimicrobial agent is a cephalosporin, and the cephalosporin is ceftiofur hydrochloride. Claim 16: A method for preventing or treating a breast disorder in a female non-human animal, characterized in that it comprises administering an effective amount of a sol-gel polymer compound in a nipple, a nipple canal or a nipple cistern of the animal. Claim 17: A system for forming a physical barrier in the nipple canal or cistern of a non-human animal for the prevention or treatment of a breast disorder, characterized in that the system comprises an administration device containing a polymeric compound sol- gel. Claim 18: The system according to claim 17, characterized in that the delivery device is a syringe.

ARP160103345A 2015-11-03 2016-11-02 A PRODUCT TO PREVENT OR TREAT A BREASTHOOD IN A NON-HUMAN ANIMAL AR106560A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562250126P 2015-11-03 2015-11-03

Publications (1)

Publication Number Publication Date
AR106560A1 true AR106560A1 (en) 2018-01-24

Family

ID=61159905

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP160103345A AR106560A1 (en) 2015-11-03 2016-11-02 A PRODUCT TO PREVENT OR TREAT A BREASTHOOD IN A NON-HUMAN ANIMAL

Country Status (1)

Country Link
AR (1) AR106560A1 (en)

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