AR106319A1 - ANTIGEN UNION PROTEINS THAT ACTIVATE THE LEPTINE RECEIVER - Google Patents
ANTIGEN UNION PROTEINS THAT ACTIVATE THE LEPTINE RECEIVERInfo
- Publication number
- AR106319A1 AR106319A1 ARP160103105A ARP160103105A AR106319A1 AR 106319 A1 AR106319 A1 AR 106319A1 AR P160103105 A ARP160103105 A AR P160103105A AR P160103105 A ARP160103105 A AR P160103105A AR 106319 A1 AR106319 A1 AR 106319A1
- Authority
- AR
- Argentina
- Prior art keywords
- antibodies
- antigen
- lepr
- binding fragments
- leptin
- Prior art date
Links
Abstract
Anticuerpos y fragmentos de unión a antígeno de anticuerpos que se unen al receptor de leptina (LEPR), y métodos de uso de los mismos. De acuerdo con determinadas formas de realización, incluye anticuerpos y fragmentos de unión a antígeno de anticuerpos que se unen a LEPR y activan la señalización de LEPR. En otras formas de realización, incluye anticuerpos y fragmentos de unión a antígeno de anticuerpos que se unen a LEPR y mejoran la sensibilización de LEPR a un antígeno. En determinadas formas de realización, incluye anticuerpos y fragmentos de unión a antígeno de anticuerpos que se unen a LEPR en presencia y en ausencia de leptina. En determinadas formas de realización, incluye anticuerpos y fragmentos de unión a antígeno de anticuerpos que inducen la señalización en células que expresan mutantes de LEPR que, en otro caso, exhiben señalización defectuosa o dificultosa en presencia de leptina. Los anticuerpos y fragmentos de unión a antígeno de la presente son útiles para el tratamiento de lipodistrofias y otras enfermedades y trastornos asociados a la deficiencia de leptina o a la resistencia a la leptina o provocados por estas.Antibodies and antigen-binding fragments of antibodies that bind to the leptin receptor (LEPR), and methods of use thereof. According to certain embodiments, it includes antibodies and antigen-binding fragments of antibodies that bind to LEPR and activate LEPR signaling. In other embodiments, it includes antibodies and antigen-binding fragments of antibodies that bind to LEPR and enhance the sensitization of LEPR to an antigen. In certain embodiments, it includes antibodies and antigen-binding fragments of antibodies that bind to LEPR in the presence and absence of leptin. In certain embodiments, it includes antibodies and antigen-binding fragments of antibodies that induce signaling in cells expressing LEPR mutants that, in another case, exhibit defective or difficult signaling in the presence of leptin. The antibodies and antigen-binding fragments herein are useful for the treatment of lipodystrophies and other diseases and disorders associated with leptin deficiency or leptin resistance or caused by them.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562240021P | 2015-10-12 | 2015-10-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR106319A1 true AR106319A1 (en) | 2018-01-03 |
Family
ID=61158540
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP160103105A AR106319A1 (en) | 2015-10-12 | 2016-10-11 | ANTIGEN UNION PROTEINS THAT ACTIVATE THE LEPTINE RECEIVER |
| ARP190102375A AR115992A2 (en) | 2015-10-12 | 2019-08-21 | ANTIGEN BINDING PROTEINS THAT ACTIVATE THE LEPTIN RECEPTOR |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP190102375A AR115992A2 (en) | 2015-10-12 | 2019-08-21 | ANTIGEN BINDING PROTEINS THAT ACTIVATE THE LEPTIN RECEPTOR |
Country Status (2)
| Country | Link |
|---|---|
| AR (2) | AR106319A1 (en) |
| MA (1) | MA42186B1 (en) |
-
2016
- 2016-10-11 MA MA42186A patent/MA42186B1/en unknown
- 2016-10-11 AR ARP160103105A patent/AR106319A1/en unknown
-
2019
- 2019-08-21 AR ARP190102375A patent/AR115992A2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR115992A2 (en) | 2021-03-17 |
| MA42186B1 (en) | 2019-08-30 |
| MA42186A1 (en) | 2018-07-31 |
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