AR105758A1 - COMPLEX PHARMACEUTICAL FORMULATION INCLUDING AMLODIPINA, LOSARTAN AND CLORTALIDONA - Google Patents
COMPLEX PHARMACEUTICAL FORMULATION INCLUDING AMLODIPINA, LOSARTAN AND CLORTALIDONAInfo
- Publication number
- AR105758A1 AR105758A1 ARP160100825A ARP160100825A AR105758A1 AR 105758 A1 AR105758 A1 AR 105758A1 AR P160100825 A ARP160100825 A AR P160100825A AR P160100825 A ARP160100825 A AR P160100825A AR 105758 A1 AR105758 A1 AR 105758A1
- Authority
- AR
- Argentina
- Prior art keywords
- pharmaceutically acceptable
- losartan
- pharmaceutical formulation
- mixture
- salts
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Reivindicación 1: Una formulación farmacéutica compleja para prevenir o tratar las enfermedades cardiovasculares, donde la formulación comprende: una primera mezcla que incluye amlodipina o una de sus sales aceptables desde el punto de vista farmacéutico, clortalidona o una de sus sales aceptables desde el punto de vista farmacéutico, y un aditivo aceptable desde el punto de vista farmacéutico; y una segunda mezcla que incluye losartan o una de sus sales aceptables desde el punto de vista farmacéutico, y un aditivo aceptable desde el punto de vista farmacéutico, en donde la primera mezcla y la segunda mezcla están presentes en una forma separada físicamente una de la otra. Reivindicación 11: Un método para preparar una formulación farmacéutica compleja para prevenir o tratar las enfermedades cardiovasculares, donde el método comprende los pasos de: a) mezclar amlodipina o una de sus sales aceptables desde el punto de vista farmacéutico, clortalidona o una de sus sales aceptables desde el punto de vista farmacéutico, y un aditivo aceptable desde el punto de vista farmacéutico; y b) mezclar losartan o una de sus sales aceptables desde el punto de vista farmacéutico, y un aditivo aceptable desde el punto de vista farmacéutico.Claim 1: A complex pharmaceutical formulation for preventing or treating cardiovascular diseases, wherein the formulation comprises: a first mixture that includes amlodipine or one of its pharmaceutically acceptable salts, chlorthalidone or one of its salts acceptable from the point of view of pharmaceutical view, and a pharmaceutically acceptable additive; and a second mixture that includes losartan or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable additive, wherein the first mixture and the second mixture are present in a physically separate form one of the other. Claim 11: A method for preparing a complex pharmaceutical formulation for preventing or treating cardiovascular diseases, wherein the method comprises the steps of: a) mixing amlodipine or one of its pharmaceutically acceptable salts, chlorthalidone or one of its salts pharmaceutically acceptable, and a pharmaceutically acceptable additive; and b) mixing losartan or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable additive.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020150045645A KR101914930B1 (en) | 2015-03-31 | 2015-03-31 | Pharmaceutical complex formulation comprising amlodipine, losartan and chlorthalidone |
Publications (1)
Publication Number | Publication Date |
---|---|
AR105758A1 true AR105758A1 (en) | 2017-11-08 |
Family
ID=57007292
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP160100825A AR105758A1 (en) | 2015-03-31 | 2016-03-29 | COMPLEX PHARMACEUTICAL FORMULATION INCLUDING AMLODIPINA, LOSARTAN AND CLORTALIDONA |
Country Status (11)
Country | Link |
---|---|
KR (1) | KR101914930B1 (en) |
CN (1) | CN108289850B (en) |
AR (1) | AR105758A1 (en) |
JO (1) | JO3461B1 (en) |
MX (1) | MX2017012459A (en) |
MY (1) | MY190016A (en) |
PH (1) | PH12017501769A1 (en) |
RU (1) | RU2713883C2 (en) |
TW (1) | TWI714560B (en) |
UY (1) | UY36595A (en) |
WO (1) | WO2016159535A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101910902B1 (en) * | 2016-11-03 | 2018-10-24 | 한미약품 주식회사 | Pharmaceutical complex formulation comprising amlodipine, losartan and chlorthalidone |
KR20180053044A (en) * | 2016-11-11 | 2018-05-21 | 주식회사유한양행 | A pharmaceutical composition in a monolithic matrix tablet form comprising chlorthalidone or its salt and amlodipine or its salt and a process for preparing the same |
KR20200143914A (en) * | 2019-06-17 | 2020-12-28 | 주식회사유한양행 | A pharmaceutical composition in a multi-layered tablet form comprising amlodipine or its salt and chlorthalidone its salt |
KR20210074428A (en) | 2019-12-11 | 2021-06-22 | 한미약품 주식회사 | Pharmaceutical complex formulation comprising amlodipine, losartan and chlorthalidone |
KR20210152943A (en) | 2020-06-09 | 2021-12-16 | 한미약품 주식회사 | Pharmaceutical combination preparation for the prevention or treatment of cardiovascular diseases including amlodipine, losartan and chlorthalidone in a single layer tablet |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5138069A (en) | 1986-07-11 | 1992-08-11 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking imidazoles |
EP0736021A4 (en) | 1993-12-23 | 1997-04-02 | Merck & Co Inc | Polymorphs of losartan and the process for the preparation of form ii of losartan |
KR100452491B1 (en) | 2001-03-29 | 2004-10-12 | 한미약품 주식회사 | A novel crystalline amlodipine camsylate and a preparing method thereof |
US20030152622A1 (en) * | 2001-10-25 | 2003-08-14 | Jenny Louie-Helm | Formulation of an erodible, gastric retentive oral diuretic |
EG24716A (en) * | 2002-05-17 | 2010-06-07 | Novartis Ag | Combination of organic compounds |
JP2009513543A (en) * | 2003-07-16 | 2009-04-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Chlorthalidone combination |
US20070237815A1 (en) * | 2006-04-06 | 2007-10-11 | Lawrence Solomon | Dosage forms and methods comprising amlodipine and chlorthalidone |
KR101247583B1 (en) * | 2006-12-08 | 2013-03-26 | 한미사이언스 주식회사 | Pharmaceutical composition comprising amlodipine or a pharmaceutically acceptable salt thereof and losartan or a pharmaceutically acceptable salt thereof |
KR20090057538A (en) * | 2007-12-03 | 2009-06-08 | 박사룡 | A composition for treating hypertension comprising angiotensin ii antagonist, calsium andtagonist and diuretics |
WO2009084040A1 (en) * | 2007-12-28 | 2009-07-09 | Rubicon Research Private Limited | Once a day formulation of angiotensin receptor blockers |
NZ594738A (en) | 2009-01-23 | 2013-11-29 | Hanmi Science Co Ltd | Solid pharmaceutical composition comprising amlodipine and losartan and process for producing same |
KR101907881B1 (en) * | 2011-12-30 | 2018-12-11 | 한미약품 주식회사 | Fixed dose combination formulation comprising losartan, amlodipine and hydrochlorothiazide |
KR101392364B1 (en) * | 2012-04-17 | 2014-05-07 | 한국유나이티드제약 주식회사 | Pharmaceutical composition comprising amlodipine and losartan having an improved stability |
-
2015
- 2015-03-31 KR KR1020150045645A patent/KR101914930B1/en active IP Right Grant
-
2016
- 2016-03-11 MX MX2017012459A patent/MX2017012459A/en unknown
- 2016-03-11 WO PCT/KR2016/002437 patent/WO2016159535A1/en active Application Filing
- 2016-03-11 MY MYPI2017703447A patent/MY190016A/en unknown
- 2016-03-11 RU RU2017134562A patent/RU2713883C2/en active
- 2016-03-11 CN CN201680020057.5A patent/CN108289850B/en active Active
- 2016-03-18 TW TW105108523A patent/TWI714560B/en not_active IP Right Cessation
- 2016-03-27 JO JOP/2016/0058A patent/JO3461B1/en active
- 2016-03-29 AR ARP160100825A patent/AR105758A1/en unknown
- 2016-03-30 UY UY0001036595A patent/UY36595A/en not_active Application Discontinuation
-
2017
- 2017-09-26 PH PH12017501769A patent/PH12017501769A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
RU2017134562A (en) | 2019-04-04 |
JO3461B1 (en) | 2020-07-05 |
RU2017134562A3 (en) | 2019-08-15 |
MY190016A (en) | 2022-03-22 |
TWI714560B (en) | 2021-01-01 |
CN108289850A (en) | 2018-07-17 |
PH12017501769B1 (en) | 2018-03-19 |
CN108289850B (en) | 2021-04-09 |
PH12017501769A1 (en) | 2018-03-19 |
KR101914930B1 (en) | 2018-11-05 |
KR20160117055A (en) | 2016-10-10 |
MX2017012459A (en) | 2018-01-30 |
UY36595A (en) | 2016-10-31 |
RU2713883C2 (en) | 2020-02-10 |
TW201639563A (en) | 2016-11-16 |
WO2016159535A1 (en) | 2016-10-06 |
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