AR105700A1 - SALT OF (S) -CSA DE S-KETAMINA, SALT OF (R) -CSA DE S-KETAMINA AND PROCESSES FOR THE PREPARATION OF S-KETAMINA - Google Patents
SALT OF (S) -CSA DE S-KETAMINA, SALT OF (R) -CSA DE S-KETAMINA AND PROCESSES FOR THE PREPARATION OF S-KETAMINAInfo
- Publication number
- AR105700A1 AR105700A1 ARP160102491A ARP160102491A AR105700A1 AR 105700 A1 AR105700 A1 AR 105700A1 AR P160102491 A ARP160102491 A AR P160102491A AR P160102491 A ARP160102491 A AR P160102491A AR 105700 A1 AR105700 A1 AR 105700A1
- Authority
- AR
- Argentina
- Prior art keywords
- ketamine
- salt
- csa
- ketamina
- acid
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Se refiere a procesos para la preparación de esketamina. La presente se refiere, además, a procesos para la resolución de S-ketamina a partir de una mezcla racémica o enantioméricamente enriquecida de ketamina. Se refiere, además, a una sal de (S)-CSA de S-ketamina, mas particularmente, una forma de monohidrato de la sal de (S)-CSA de S-ketamina; y a una sal de (R)-CSA de R-ketamina. Reivindicación 6: Un proceso para la preparación de una forma monohidratada de la sal de ácido (S)-canforsulfónico de S-ketamina; el proceso comprende hacer reaccionar la ketamina con ácido (S)-canforsulfónico, en donde el ácido (S)-canforsulfónico está presente en una cantidad en el intervalo de aproximadamente 0,5 a aproximadamente 2,0 equivalentes molares (en relación con la cantidad molar de ketamina); en presencia de agua, en donde el agua está presente en una cantidad en el intervalo de aproximadamente 3,5% a aproximadamente 15%; en un solvente orgánico; a una temperatura en el intervalo de aproximadamente 20ºC a aproximadamente la temperatura de reflujo del solvente; para producir la forma monohidratada correspondiente de la sal de ácido (S)-canforsulfónico de S-ketamina; en donde la forma monohidratada de la sal de ácido (S)-canforsulfónico de S-ketamina está presente en un exceso enantiomérico en el intervalo de aproximadamente 50% a aproximadamente 100%.It refers to processes for the preparation of esketamine. This also refers to processes for the resolution of S-ketamine from a racemic or enantiomerically enriched mixture of ketamine. It also refers to an (S) -CSA salt of S-ketamine, more particularly, a monohydrate form of the (S) -CSA salt of S-ketamine; and to a salt of (R) -CSA of R-ketamine. Claim 6: A process for the preparation of a monohydrated form of the S-ketamine (S) -camphoraulfonic acid salt; The process comprises reacting the ketamine with (S) -camphoraulfonic acid, wherein (S) -camphorulfonic acid is present in an amount in the range of about 0.5 to about 2.0 molar equivalents (in relation to the amount ketamine molar); in the presence of water, wherein water is present in an amount in the range of about 3.5% to about 15%; in an organic solvent; at a temperature in the range of about 20 ° C to about the reflux temperature of the solvent; to produce the corresponding monohydrate form of the S-ketamine acid (S) -camphoraulfonic salt; wherein the monohydrated form of the S-ketamine (S) -camphoraulfonic acid salt is present in an enantiomeric excess in the range of about 50% to about 100%.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ARP160102491A AR105700A1 (en) | 2016-08-12 | 2016-08-12 | SALT OF (S) -CSA DE S-KETAMINA, SALT OF (R) -CSA DE S-KETAMINA AND PROCESSES FOR THE PREPARATION OF S-KETAMINA |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ARP160102491A AR105700A1 (en) | 2016-08-12 | 2016-08-12 | SALT OF (S) -CSA DE S-KETAMINA, SALT OF (R) -CSA DE S-KETAMINA AND PROCESSES FOR THE PREPARATION OF S-KETAMINA |
Publications (1)
Publication Number | Publication Date |
---|---|
AR105700A1 true AR105700A1 (en) | 2017-11-01 |
Family
ID=60451230
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP160102491A AR105700A1 (en) | 2016-08-12 | 2016-08-12 | SALT OF (S) -CSA DE S-KETAMINA, SALT OF (R) -CSA DE S-KETAMINA AND PROCESSES FOR THE PREPARATION OF S-KETAMINA |
Country Status (1)
Country | Link |
---|---|
AR (1) | AR105700A1 (en) |
-
2016
- 2016-08-12 AR ARP160102491A patent/AR105700A1/en unknown
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CL2019001066A1 (en) | Salt of (s) -csa of s-ketamine, salt of (r) -csa of s-ketamine and processes for the preparation of s-ketamine (divisional application 201702854) | |
AR085155A1 (en) | PROCESSES TO PREPARE QUINOLINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS | |
AR105494A1 (en) | METHOD FOR PREPARING ACID DERIVATIVES 3- (2-ANILINO-1-CICLOHEXIL-1H-BENCIMIDAZOL-5-IL) SUBSTITUTED PROPANOIC | |
AR063449A1 (en) | CHEMICAL PROCESS FOR QUINAZOLINE DERIVATIVES, INTERMEDIARIES | |
AR103230A1 (en) | PROCESSES FOR THE PREPARATION OF A DIARILTIOHIDANTOINE COMPOUND | |
AR117002A2 (en) | PROCESS FOR THE PREPARATION OF KINASE C-FMS INHIBITORS | |
AR095727A1 (en) | PREPARATION OF PYRIMIDINE INTERMEDIARIES | |
AR057022A1 (en) | PROCESS TO RESOLVE A MANDELIC ACID R OR S FROM ITS RACEMIC MIX | |
CL2019000016A1 (en) | Novel processes to prepare soluble guanylate cyclase stimulators. | |
BR112017000417A2 (en) | process for preparing substituted phenyl alkanes | |
EA201490383A1 (en) | METHOD FOR GETTING SITAHLIPTINE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS | |
CL2019000045A1 (en) | Ethynyl derivatives. | |
AR111259A1 (en) | CATALYTIC SYSTEM FOR THE SCALABLE PREPARATION OF INDOXACARB | |
AR105700A1 (en) | SALT OF (S) -CSA DE S-KETAMINA, SALT OF (R) -CSA DE S-KETAMINA AND PROCESSES FOR THE PREPARATION OF S-KETAMINA | |
BR112017025135A2 (en) | processes for isolating a compound and for preparing a compound | |
BR112015021151A2 (en) | Process for the preparation of (2s, 5r) -sulfuric acid mono - {[(4-aminopiperidin-4-yl) carbonyl] -7-oxo-1,6-diazabicyclo [3.2.1] -oct-6-yl} ester | |
AR100095A1 (en) | SOLID FORMS OF ACID {[(2R, 3S, 4R, 5S) -4- (4-CHLORO-2-FLUORO-PHENYL) -3- (3-CHLORO-2-FLUORO-PHENYL) -4-CIANO-5- (2,2-DIMETIL-PROPIL) -PIRROLIDIN-2-CARBONIL] -AMINO} -3-METOXI-BENZOICO | |
MA35147B1 (en) | Novel process for the synthesis of (2e) -3- (3,4-dimethoxyphenyl) prop-2-enenitrile and application to the synthesis of ivabradine and its addition salts with a pharmaceutically acceptable acid | |
AR064215A1 (en) | PROCESS FOR OBTAINING R-ENANTIOMERO DE SALBUTAMOL | |
CL2015000975A1 (en) | Boussingaultite production process from liquid effluents containing magnesium sulphate | |
AR094240A1 (en) | PROCESS TO PRODUCE PIRAZOL COMPOSITE CRYSTAL | |
AR108197A1 (en) | PROCESS FOR THE DEVELOPMENT OF IDALOPIRDINE THROUGH THE HYDROGENATION OF AN IMINA | |
AR110384A1 (en) | PROCESS FOR THE MANUFACTURE OF DIAZEPIN DERIVATIVES | |
AR049575A1 (en) | RESOLUTION OF AN ARIL-CONDENSED AZAPOLICICLIC COMPOUND | |
EA201400269A1 (en) | METHOD OF SYNTHESIS OF 7,8-DIMETOXY -1,3-DIHYDRO-2H-3-BENZAZEPIN-2-SHE COMPOUNDS AND IVABRADIN |