AR105700A1 - SALT OF (S) -CSA DE S-KETAMINA, SALT OF (R) -CSA DE S-KETAMINA AND PROCESSES FOR THE PREPARATION OF S-KETAMINA - Google Patents

SALT OF (S) -CSA DE S-KETAMINA, SALT OF (R) -CSA DE S-KETAMINA AND PROCESSES FOR THE PREPARATION OF S-KETAMINA

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Publication number
AR105700A1
AR105700A1 ARP160102491A ARP160102491A AR105700A1 AR 105700 A1 AR105700 A1 AR 105700A1 AR P160102491 A ARP160102491 A AR P160102491A AR P160102491 A ARP160102491 A AR P160102491A AR 105700 A1 AR105700 A1 AR 105700A1
Authority
AR
Argentina
Prior art keywords
ketamine
salt
csa
ketamina
acid
Prior art date
Application number
ARP160102491A
Other languages
Spanish (es)
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Priority to ARP160102491A priority Critical patent/AR105700A1/en
Publication of AR105700A1 publication Critical patent/AR105700A1/en

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Abstract

Se refiere a procesos para la preparación de esketamina. La presente se refiere, además, a procesos para la resolución de S-ketamina a partir de una mezcla racémica o enantioméricamente enriquecida de ketamina. Se refiere, además, a una sal de (S)-CSA de S-ketamina, mas particularmente, una forma de monohidrato de la sal de (S)-CSA de S-ketamina; y a una sal de (R)-CSA de R-ketamina. Reivindicación 6: Un proceso para la preparación de una forma monohidratada de la sal de ácido (S)-canforsulfónico de S-ketamina; el proceso comprende hacer reaccionar la ketamina con ácido (S)-canforsulfónico, en donde el ácido (S)-canforsulfónico está presente en una cantidad en el intervalo de aproximadamente 0,5 a aproximadamente 2,0 equivalentes molares (en relación con la cantidad molar de ketamina); en presencia de agua, en donde el agua está presente en una cantidad en el intervalo de aproximadamente 3,5% a aproximadamente 15%; en un solvente orgánico; a una temperatura en el intervalo de aproximadamente 20ºC a aproximadamente la temperatura de reflujo del solvente; para producir la forma monohidratada correspondiente de la sal de ácido (S)-canforsulfónico de S-ketamina; en donde la forma monohidratada de la sal de ácido (S)-canforsulfónico de S-ketamina está presente en un exceso enantiomérico en el intervalo de aproximadamente 50% a aproximadamente 100%.It refers to processes for the preparation of esketamine. This also refers to processes for the resolution of S-ketamine from a racemic or enantiomerically enriched mixture of ketamine. It also refers to an (S) -CSA salt of S-ketamine, more particularly, a monohydrate form of the (S) -CSA salt of S-ketamine; and to a salt of (R) -CSA of R-ketamine. Claim 6: A process for the preparation of a monohydrated form of the S-ketamine (S) -camphoraulfonic acid salt; The process comprises reacting the ketamine with (S) -camphoraulfonic acid, wherein (S) -camphorulfonic acid is present in an amount in the range of about 0.5 to about 2.0 molar equivalents (in relation to the amount ketamine molar); in the presence of water, wherein water is present in an amount in the range of about 3.5% to about 15%; in an organic solvent; at a temperature in the range of about 20 ° C to about the reflux temperature of the solvent; to produce the corresponding monohydrate form of the S-ketamine acid (S) -camphoraulfonic salt; wherein the monohydrated form of the S-ketamine (S) -camphoraulfonic acid salt is present in an enantiomeric excess in the range of about 50% to about 100%.

ARP160102491A 2016-08-12 2016-08-12 SALT OF (S) -CSA DE S-KETAMINA, SALT OF (R) -CSA DE S-KETAMINA AND PROCESSES FOR THE PREPARATION OF S-KETAMINA AR105700A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ARP160102491A AR105700A1 (en) 2016-08-12 2016-08-12 SALT OF (S) -CSA DE S-KETAMINA, SALT OF (R) -CSA DE S-KETAMINA AND PROCESSES FOR THE PREPARATION OF S-KETAMINA

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ARP160102491A AR105700A1 (en) 2016-08-12 2016-08-12 SALT OF (S) -CSA DE S-KETAMINA, SALT OF (R) -CSA DE S-KETAMINA AND PROCESSES FOR THE PREPARATION OF S-KETAMINA

Publications (1)

Publication Number Publication Date
AR105700A1 true AR105700A1 (en) 2017-11-01

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
ARP160102491A AR105700A1 (en) 2016-08-12 2016-08-12 SALT OF (S) -CSA DE S-KETAMINA, SALT OF (R) -CSA DE S-KETAMINA AND PROCESSES FOR THE PREPARATION OF S-KETAMINA

Country Status (1)

Country Link
AR (1) AR105700A1 (en)

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