AR105689A1 - GITRL FUSION PROTEINS AND ITS USES - Google Patents

GITRL FUSION PROTEINS AND ITS USES

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Publication number
AR105689A1
AR105689A1 ARP160102478A ARP160102478A AR105689A1 AR 105689 A1 AR105689 A1 AR 105689A1 AR P160102478 A ARP160102478 A AR P160102478A AR P160102478 A ARP160102478 A AR P160102478A AR 105689 A1 AR105689 A1 AR 105689A1
Authority
AR
Argentina
Prior art keywords
subunits
fusion polypeptides
fusion proteins
proteins
domain
Prior art date
Application number
ARP160102478A
Other languages
Spanish (es)
Inventor
Mason Durham Nicholas
Leyland Rebecca
Sridharan Sudharsan
Bamber Lisa
Ramsay Higazi Daniel
Lynn Young Lesley
Jo Tigue Natalie
Anthony Stewart Ross
Original Assignee
Medimmune Ltd
Medimmune Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune Ltd, Medimmune Llc filed Critical Medimmune Ltd
Publication of AR105689A1 publication Critical patent/AR105689A1/en

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  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Subunidades de polipéptidos de fusión GITRL que comprenden un dominio Fc de la IgG, un dominio de trimerización y el dominio de unión al ligando del receptor GITR, donde las subunidades de los polipéptidos de fusión se pueden auto-ensamblar en proteínas hexaméricas. También se proveen métodos para elaborar las subunidades de polipéptidos de fusión y las proteínas hexaméricas, y métodos de uso, por ejemplo, en el tratamiento de cáncer. Polinucleótido, composición, vector y célula huésped.Subunits of GITRL fusion polypeptides comprising an Fc domain of IgG, a trimerization domain and the ligand binding domain of the GITR receptor, where subunits of fusion polypeptides can be self-assembled into hexamericas proteins. Methods for making subunits of fusion polypeptides and hexamerican proteins are also provided, and methods of use, for example, in the treatment of cancer. Polynucleotide, composition, vector and host cell.

ARP160102478A 2015-08-12 2016-08-11 GITRL FUSION PROTEINS AND ITS USES AR105689A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562204212P 2015-08-12 2015-08-12

Publications (1)

Publication Number Publication Date
AR105689A1 true AR105689A1 (en) 2017-11-01

Family

ID=60451207

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP160102478A AR105689A1 (en) 2015-08-12 2016-08-11 GITRL FUSION PROTEINS AND ITS USES

Country Status (1)

Country Link
AR (1) AR105689A1 (en)

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